Protein Alignment Sik2 and par-1

DIOPT Version :9

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 1248
• Identity: 360/1248 - (28%)
• Similarity: 516/1248 - (41%)
• Gaps: 341/1248 - (27%)

  Fly    14 SQAKSEESQPPEDQKKKQPQHE-RNEKQLDKPPENLP-------------QNGKTE--------- 55
            |.:.|..|...:.|:::|.||: .|...:..||...|             .|..|.
  Fly    60 SISTSSHSVKDQQQQQQQQQHDSANANIVSLPPTTTPVANTNTMMPIVTSSNSATSNSTAATPTP 124

  Fly    56 -----AKGAEGACSHPPLDALRSSV-------------------LLDAGAASPSIDAIVACKDAL 96
                 |.|..|:.|..|.....|:.                   :...||...|.::.|....|:
  Fly   125 ASGAAATGGVGSVSQGPATVSASAANTNHSHQHSHQHHHHVANNMTTDGARLSSNNSAVVASSAI 189

  Fly    97 LAQKLFASGGGSTP------------GPSP----TSSAVGAGGISGKDLLKLKEPMR-------V 138
            ........|.|..|            .||.    ||||.|:..:.    ::...|||       :
  Fly   190 NHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQ----MRSSAPMRWRATEEHI 250

  Fly   139 GFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKL 203
            |.|.:.:||||||||.||||:|..|..|||||||||:||:..:|||::|||.|||.|.||:|:||
  Fly   251 GKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKL 315

  Fly   204 YQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAEN 268
            :||:||:..:|::.||||.||:|||:..:|||.|..||.||.||:|||:|||:|.|:||||||||
  Fly   316 FQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAEN 380

  Fly   269 LLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVC 333
            ||||..:|||||||||||.|.||..|.|:||||||||||:|:||:|.|||:|:|||||:||.||.
  Fly   381 LLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS 445

  Fly   334 GALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLE 398
            |:||||||||:.||:|||.|::||||:||::||:|:|:.|||.|.:|.:::.|...:||
  Fly   446 GSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWM------ 504

  Fly   399 HVLIAKYNLGAER---QTSVEPSEDIL---RIMAEYVGIGSDKT--RASLKKNTYDHVAAIYLLL 455
                   |:|.|.   :..:||..|:.   ||.| .|.:|.:::  .|||.:..||.|.|.||||
  Fly   505 -------NMGFEEDELKPYIEPKADLADPKRIEA-LVAMGYNRSEIEASLSQVRYDDVFATYLLL 561

  Fly   456 QDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRL 520
             .|.|...|.......|:|     :.|.|  |.||.......:..||.|        ....|:.:
  Fly   562 -GRKSTDPESDGSRSGSSL-----SLRNI--SGNDAGANAGSASVQSPT--------HRGVHRSI 610

  Fly   521 SRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPL 585
            |...|  ...|.|.:|..||                               |.......|:|
  Fly   611 SASST--KPSRRASSGVGPT-------------------------------NAAATVAAATG--- 639

  Fly   586 PMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAG 650
                  ...|.:|: :|.::..|...|.|:.|:..|.:...:.::. :|...||....|
  Fly   640 ------AVGAVNPS-NNYNAAGSAADRASVGSNFKRQNTIDSATIK-ENTARLAAQNQR------ 690

  Fly   651 GGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPP---KAESSVGGVPPP 712
                     |.::.|...|.::..:....:...|.          |.||.   :..|...|:.|.
  Fly   691 ---------PASATQKMLTTADTTLNSPAKPRTAT----------KYDPTNGNRTVSGTSGIIPR 736

  Fly   713 ASTTPTSSTAGPESGSAPCPGEIN-------GKTIKT-------MSSSSSFDS---KANLGQSFR 760
            .|||....|:..|..:. .|.|.|       ...:|:       :.|.|:|.|   :|....:..
  Fly   737 RSTTLYEKTSSTEKTNV-IPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALE 800

  Fly   761 YKMSAEA-------------SKLFQTLQESPLPVEQRTKRRV-----HVGSTNGSGGD----SGQ 803
            |..::.|             |||.....:.|...::..|.||     .:.:|:....|    ..:
  Fly   801 YSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIR 865

  Fly   804 ETNDAKSNGDSRSEKKVL--AQGSSSTD-------EGCETDQGNDPGSASQESKGSNGG------ 853
            |..|..:....:.|:.||  ..|..:||       |.|:..:.:..|...:...|::.|
  Fly   866 EVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIAS 930

  Fly   854 ------------GSGNANGGPTSHSSSDLTRLVGTTT----SGQSHKMRSYASSSSSSGVLAGSA 902
                        .:...|...|:...:|.|..:.||.    |..|....|..|....|  |....
  Fly   931 RIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRS--LTSQQ 993

  Fly   903 GSYSKSLSQNLSRGSS----KSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASASPAGI 963
            ||..:..|: ||.|.|    |||                    |.:.:..|.   :|.|:.....
  Fly   994 GSQRRKKSR-LSTGGSEDQKKSN--------------------SLLSAFQMY---SPFSSKENMQ 1034

  Fly   964 SSEHSSERSLYGSHNSCIHM----PGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIH 1024
            |||...:          :|:    ||.   .:.:|..:..:|. ||....:..||
  Fly  1035 SSEEVED----------LHVIDTQPGH---SVDVPLFADFSPI-NPIMEEDAEGV---------- 1075

  Fly  1025 FREGRRASDGLVAQG----------------------LLSSGSLLGTSRVYGSYRYEQAKRHGWL 1067
              ||.:.|:..|..|                      :..:|||:......|  |:..|.:.|
  Fly  1076 --EGGKTSEAKVISGGSGQKVKGDGGGGGGGNRLKRNIKHTGSLIVRKLTAG--RHNDADKKG-- 1134

  Fly  1068 EIQQLQQLQQEAA 1080
            .|::..:.|||.|
  Fly  1135 AIRKKDKEQQEVA 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	159/251 (63%)
		S_TKc	141..392	CDD:214567	159/250 (64%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	159/251 (63%)
		S_TKc	253..504	CDD:214567	159/250 (64%)
		UBA_MARK_Par1	525..563	CDD:270522	16/39 (41%)
		MARK1-3_C	839..936	CDD:213381	18/96 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810