Protein Alignment Sik2 and Gm4922

DIOPT Version :9

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_808374.1
• Gene: Gm4922 / 237300
• MGIID: 3644318
• Length: 497
• Species: Mus musculus
• Alignment Length: 450
• Identity: 140/450 - (31%)
• Similarity: 215/450 - (47%)
• Gaps: 66/450 - (14%)

  Fly   141 YDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQ 205
            |.:.:|:.:.....|:|..|.:|...||:|.:...:..:..:.    ||||||.|.||:|:.|.|
Mouse    28 YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKVS----EVEIMKMLSHPNIVSLLQ 88

  Fly   206 VMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLL 270
            |:||:..||::.|.|...::.:.:.:...:.|..||..|.|::||:.|||.:|:||||||.:|::
Mouse    89 VIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNVI 153

  Fly   271 LDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGA 335
            :|.:.|:||.|||....|.||:.|...||:..:..||:|.|..|.||::|||:|||:||.:|.|.
Mouse   154 VDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTGI 218

  Fly   336 LPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHV 400
            .||.||||..:...||.||:.||:.:|.:...:|..:|.....:|.|...:..|.|    |.|..
Mouse   219 FPFVGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPW----LQEGE 279

  Fly   401 LIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLL-----QDRVS 460
            ....::...:  ||. |..||:..| :.:|......|.|||...:|...|.|.||     ||..:
Mouse   280 KTITFHSNGD--TSF-PDPDIMAAM-KNIGFHVQDIRESLKHRKFDETMATYNLLRAEACQDDGN 340

  Fly   461 H--KKEQSNGL---------GASALASSTSAS----RMIYSSRNDHQ----------------PT 494
            :  .|..:.|:         ||.:|.....||    :::.||..:||                ||
Mouse   341 YVQTKLMNPGMPPFPSVTDSGAFSLPPRRRASEPSFKVLVSSTEEHQLRQTGGTNAPFPPKKTPT 405

  Fly   495 QQQSQQQSKTIST---------------SSILAKDQCHKRLSRHQTVLMSERNAHAGATP 539
            ..:||:|.:.::.               ||.....|..|..|..:   .||.:.....||
Mouse   406 MGRSQKQKRAMTAPCICLLRNTYIDTEDSSFCTSSQAEKTSSDPE---KSETSTSCPLTP 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	94/250 (38%)
		S_TKc	141..392	CDD:214567	94/250 (38%)
Gm4922	NP_808374.1	STKc_AMPK-like	27..274	CDD:270905	94/249 (38%)
		UBA_MARK_Par1	293..330	CDD:270522	12/37 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..460		5/23 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810