Protein Alignment Sik2 and TSSK2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_443732.3
• Gene: TSSK2 / 23617
• HGNCID: 11401
• Length: 358
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 134/391 - (34%)
• Similarity: 196/391 - (50%)
• Gaps: 74/391 - (18%)

  Fly   141 YDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQK-VYREVEIMKRLKHPHIIKLY 204
            |.:...:|||::|.||.|.....|..||:||||:.:.....::: :.||::|:..:.|..|||.|
Human    12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTY 76

  Fly   205 QVMETKN-MIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAEN 268
            ::.||.: .|||:.|...||::.::|...|.:.|..||..|.|:.|||:|||...|||||||.||
Human    77 EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCEN 141

  Fly   269 LLLDLNMNIKIADFGFSNHF---KPGELL--ATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVL 328
            ||||.:.|||::|||||...   ..|.::  .|:|||..||||||.:...|.....|||||||:|
Human   142 LLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVIL 206

  Fly   329 YVLVCGALPFDGSTLQS-LRDRVLSGRFRIPF----FMSSECEHLIRRMLVLEPTRRYTIDQIKR 388
            |::|||::|:|.|.::. ||   :....|:.|    .::.||:.||.|||..:.::|..||:|..
Human   207 YIMVCGSMPYDDSDIRKMLR---IQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILS 268

  Fly   389 HRWMCPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTY-----DHV 448
            |.|:.|.             ..:.||          .|.:...|..|.||..|.:|.     ||
Human   269 HSWLQPP-------------KPKATS----------SASFKREGEGKYRAECKLDTKTGLRPDH- 309

  Fly   449 AAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAK 513
                     |..||      |||.      :..|::....|       :::.:.:...||.  ||
Human   310 ---------RPDHK------LGAK------TQHRLLVVPEN-------ENRMEDRLAETSR--AK 344

  Fly   514 D 514
            |
Human   345 D 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	108/262 (41%)
		UBA_SIK	418..458	CDD:270523	9/44 (20%)
TSSK2	NP_443732.3	STKc_TSSK1_2-like	10..272	CDD:271067	108/262 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..358		15/75 (20%)