DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik2 and Sik2

DIOPT Version :9

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:NP_848825.2 Gene:Sik2 / 235344 MGIID:2445031 Length:931 Species:Mus musculus


Alignment Length:1283 Identity:398/1283 - (31%)
Similarity:515/1283 - (40%) Gaps:475/1283 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 PMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPH 199
            |:||||||||.|:||||||||||.||||||.|||||||||||||..||:|:||||:|||.|.|||
Mouse    14 PVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPH 78

  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDL 264
            |||||||||||:|:|:|:|||..||||||:|.:||::||.||.|||||:|||:|||.:.:|||||
Mouse    79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDL 143

  Fly   265 KAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLY 329
            ||||||||.|||||||||||.|.||.|||||||||||||||||||||:||.||::||||:|||||
Mouse   144 KAENLLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLY 208

  Fly   330 VLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCP 394
            |||||||||||.||..||.|||.||||||:|||.:|||||||||||:|::|.:|.|||.|:||..
Mouse   209 VLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLI 273

  Fly   395 EL-LEHVLIAKYNLGAERQTSV-EPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQD 457
            |: ::..::  |....|.:.|: |.:|.:||:| ..:||...||..||:..:|:|.||||.||.:
Mouse   274 EVPVQRPIL--YPQEQENEPSIGEFNEQVLRLM-HSLGIDQQKTVESLQNKSYNHFAAIYFLLVE 335

  Fly   458 RV-SHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQ---SQQQSKTISTSSILAKDQCHK 518
            |: ||:..                           .|.:|:   .|::..||:..::        
Mouse   336 RLKSHRSS---------------------------FPVEQRLDGRQRRPSTIAEQTV-------- 365

  Fly   519 RLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGI 583
              ::.|||                               .||:|.|               ...:
Mouse   366 --AKAQTV-------------------------------GLPVTLH---------------PPNV 382

  Fly   584 PLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMME 648
            .| ||.|.||.|::                                                   
Mouse   383 RL-MRSTLLPQASN--------------------------------------------------- 395

  Fly   649 AGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPA 713
                 |.|...|.:|.|......|       |:|              .|.||....:....||.
Mouse   396 -----VEAFSFPTSSCQAEAAFME-------EEC--------------VDTPKVNGCLLDPVPPV 434

  Fly   714 STTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESP 778
            ..         ..|....|                                   |.:.:|     
Mouse   435 LV---------RKGCQSLP-----------------------------------SSMMET----- 450

  Fly   779 LPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCET--DQGNDPG 841
                                                            |.|||.||  :...||.
Mouse   451 ------------------------------------------------SIDEGLETEGEAEEDPS 467

  Fly   842 SASQESKGSNGGGSGNANGGPTSHSSSDLT-RLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSY 905
            .|.:..:.:        ..|...|:.|::| :||                      |:.|:...:
Mouse   468 QAFEAFQAT--------RSGQRRHTLSEVTNQLV----------------------VMPGAGKMF 502

  Fly   906 SKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLAT-PTPASASPAGISSEHSS 969
            |.|.:.:|....|:.:.......|:|...|     ||.  ...|||. |:|...||         
Mouse   503 SMSDNPSLESVDSEYDMGSAQRDLNFLEDS-----PSL--KDIMLANQPSPRMTSP--------- 551

  Fly   970 ERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRASDG 1034
                      .|.:..|.|....|  ||......|               |||:.|||||||||.
Mouse   552 ----------FISLRPANPAMQAL--SSQKREAHN---------------RSPVSFREGRRASDT 589

  Fly  1035 LVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHSHPHAHQHPHQHPHPH 1099
            .:.||:::          :..:....|:..|.||:.::|.|.::.. .::.|..       ....
Mouse   590 SLTQGIVA----------FRQHLQNLARTKGILELNKVQLLYEQMG-SNADPTL-------TSTA 636

  Fly  1100 PQAYGLEELCQFPNGQF-------YALPGKHHPLLTLPHHHAHPAQH---HHGHHSLFHSGHQAT 1154
            ||...|...|  |..:.       .:|....||.|:       |.|.   .:..|.|     |..
Mouse   637 PQLQDLSSSC--PQEEISQQQESVSSLSASMHPQLS-------PQQSLETQYLQHRL-----QKP 687

  Fly  1155 PLLLEAAAGGDMYGHGCYAPPPPPPGLYTHHQLGVGMAVPMSPMQKPPLQQQLLQHRLLQQKRQL 1219
            .||.:|.:...:|   |..||                         ..|:|||.:|| |||||..
Mouse   688 NLLPKAQSPCPVY---CKEPP-------------------------RSLEQQLQEHR-LQQKRLF 723

  Fly  1220 FQKQYALEA-----QLAGRHH--HHQQHSHHHHHHFGHSLGPP---------PPPAPAPEH---- 1264
            .|||..|:|     |:|...:  ..||.:..|......|..||         |...|:.|.    
Mouse   724 LQKQSQLQAYFNQMQIAESSYPGPSQQLALPHQETPLTSQQPPSFSLTQALSPVLEPSSEQMQFS 788

  Fly  1265 HLADELYELALLDRPRSGTPRLQHSMTMPGAHAFSQMNLKTSYISQSDQVPGAAPNGAGSGGSAA 1329
            ....:..|:.|  :|...||..|....:|            |.:.|..|.|...|          
Mouse   789 SFLSQYPEMQL--QPLPSTPGPQAPPPLP------------SQLQQHQQPPPPPP---------- 829

  Fly  1330 GVSCSAPPSTAPGTPTVKCKPTTPHGHSLDSDYHT-STPVLSLFTPNW 1376
                 .||...||     ..||     ||...|.| ..|..:...||:
Mouse   830 -----PPPPQQPG-----AAPT-----SLQFSYQTCELPSTTSSVPNY 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 196/251 (78%)
S_TKc 141..392 CDD:214567 195/250 (78%)
Sik2NP_848825.2 STKc_SIK 19..271 CDD:270973 196/251 (78%)
S_TKc 20..271 CDD:214567 195/250 (78%)
UBA_SIK2 297..341 CDD:270592 20/44 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..586 3/20 (15%)
RK-rich region, required for cAMP responsiveness. /evidence=ECO:0000269|PubMed:29211348 595..624 2/28 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..662 2/30 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..768 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 798..842 12/44 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849333
Domainoid 1 1.000 417 1.000 Domainoid score I653
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 494 1.000 Inparanoid score I1384
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000311
OrthoInspector 1 1.000 - - otm43781
orthoMCL 1 0.900 - - OOG6_105552
Panther 1 1.100 - - O PTHR24343
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2250
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.750

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