DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik2 and SIK3

DIOPT Version :9

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:NP_001353615.1 Gene:SIK3 / 23387 HGNCID:29165 Length:1369 Species:Homo sapiens


Alignment Length:1565 Identity:441/1565 - (28%)
Similarity:620/1565 - (39%) Gaps:492/1565 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 AKGAEGACSHPPLDALRSSVLLDAGAASPSIDAIVACKDALLAQKLFASGGGSTPGPSPTSSAVG 120
            |.||.||..            ...|.|.|:            .:.|.....||...|:..|.|.|
Human     6 ASGAGGAAG------------AGTGGAGPA------------GRLLPPPAPGSPAAPAAVSPAAG 46

  Fly   121 -----AGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQT 180
                 |....|      ..|.|:|:|:|:||||||||||||.|.|.:||.:||||||||:|||:.
Human    47 QPRPPAPASRG------PMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEE 105

  Fly   181 NLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFW 245
            ||:|::|||:|||.|.|||||:|||||||:.|||:|:||||.|||||::..:|||:|..||.||.
Human   106 NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK 170

  Fly   246 QIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFE 310
            ||::||.:||.:.||||||||||||||.|:|||||||||||.|.||:||.||||||||||||:||
Human   171 QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE 235

  Fly   311 GKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVL 375
            ||:|.||::|||||||||||||||||||||||||:||.|||||:||||||||:|||||||.||||
Human   236 GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL 300

  Fly   376 EPTRRYTIDQIKRHRWM---------------CPELLEHVLIAKYNLGAERQTSVEP-SEDILRI 424
            :|.:|.:::||.:|:||               |.:|.|           |||  |:| :||:|..
Human   301 DPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE-----------ERQ--VDPLNEDVLLA 352

  Fly   425 MAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGA-----SALASSTSA---S 481
            | |.:|:..::|..||:.:.|||.:|||.||.||  ||:.::..|||     .|||.....   :
Human   353 M-EDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDR--HKRHKTLRLGALPSMPRALAFQAPVNIQA 414

  Fly   482 RMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQ------------CHKRLSRH-------QTVL 527
            ....::.|...|..|....:::.:.....|..|.            .:..:.||       :|.:
Human   415 EQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEV 479

  Fly   528 MSERN----AHAGATPTVP----DPGPGYYAKYGPLQLPLP-------------------LTGHS 565
            |.:..    ...|..|..|    .|...:.....|:|...|                   |.|..
Human   480 MEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMG 544

  Fly   566 HLTGYLNGGG--VEVDASGI------PLPM-RYTPLPTAASPAPSNCSS-----------TSSRV 610
            .|....:.||  :::.|..:      |.|: ..||...|.:|.....|.           .::|.
Human   545 PLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRS 609

  Fly   611 GRHSLSSSSPRS----------------------------HR-----------------PV---- 626
            .||:|:.::|.:                            ||                 ||    
Human   610 KRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFS 674

  Fly   627 --AISL--------SIDNNPSLANLR--CREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQST 679
              |.|:        .:.||.|:..|:  |.::.:..||.:.       .:.|.:|..:.::.|..
Human   675 DGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQID-------ERTLEKTQQQHMLYQQE 732

  Fly   680 EDCRALLQQ-STAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTM 743
            :..:.|.|| ..::...:..||...:...   .||..|........:..|.| |...|....:..
Human   733 QHHQILQQQIQDSICPPQPSPPLQAACEN---QPALLTHQLQRLRIQPSSPP-PNHPNNHLFRQP 793

  Fly   744 SSSSSFDSKANL-----GQSFRYKMSAEASKLFQTLQE---SP-------LPVEQRTKRRVHVGS 793
            |:|....|.|.:     ..|.:::.....|.:||...|   ||       |.::|..:       
Human   794 SNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQ------- 851

  Fly   794 TNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCETDQGNDPGSASQESKGSNGGG---S 855
                   |.|.|...:...|..|                     |.||:|:    ||:|.|   |
Human   852 -------SQQVTIQVQEPVDMLS---------------------NMPGTAA----GSSGRGISIS 884

  Fly   856 GNANGGPTSHSSSDLTRLVGTTTSGQ---SHKMRSYASSSSSSGVLAGSAGSYSKS-----LSQN 912
            .:|......|.    |.|:.|.:.|.   |.::.:.::.:.|..|...|..:|.::     |..:
Human   885 PSAGQMQMQHR----TNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSD 945

  Fly   913 LSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASASPAGISSEHSSERSLYGSH 977
            .||||..|          ::..:|.|..|     :..|..| |....|....|.|...     .|
Human   946 QSRGSPSS----------YSPSTGVGFSP-----TQALKVP-PLDQFPTFPPSAHQQP-----PH 989

  Fly   978 NSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRASDGLVAQGLLS 1042
            .:...:..||               .:||||      .:...:...|           :.|||||
Human   990 YTTSALQQAL---------------LSPTPP------DYTRHQQVPH-----------ILQGLLS 1022

  Fly  1043 -SGSLLGTS--RVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHSHPHAHQHPHQ------HPHP 1098
             ..||.|.|  |:..:...:..||......||.||.||:     .:....:|.:|      .|..
Human  1023 PRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQ-----EYQELFRHMNQGDAGSLAPSL 1082

  Fly  1099 HPQAYGLEELCQFPNGQFYALPGKHHPLLTLPHHHAHP-------AQ------------HHHGHH 1144
            ..|:....:...:.|...|             |||..|       ||            |.:.|.
Human  1083 GGQSMTERQALSYQNADSY-------------HHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQ 1134

  Fly  1145 -SLFHS---------------------------GHQATPLLLEAAAGGDMYGHGCYAPPPPPPGL 1181
             :|.||                           |...:||||.....||         |....|.
Human  1135 PALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGD---------PESLLGT 1190

  Fly  1182 YTH----------HQLGVGMAVPMSPMQKPPLQQ-----------QLLQHRLLQQKRQLFQKQYA 1225
            .:|          ||.....:....|.::|.:..           :|..|..|         .|.
Human  1191 VSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGL---------GYP 1246

  Fly  1226 LEAQLAGRHHHHQQHSHHHHHHFGHSLGPPPPPAPAPEHHLADELYELALLDRPRSGTPRLQHSM 1290
            ....:   |.||:..:...||...:|                |:.| :.|.:.|         .|
Human  1247 ARPSV---HEHHRPRALQRHHTIQNS----------------DDAY-VQLDNLP---------GM 1282

  Fly  1291 TMPGAHAFSQMNLKTSYISQSDQVPGAAPNGAGSGGSAAGVSCSAP------PSTAPGTPTV--K 1347
            ::....|.|...:..:.:|||..:      |:..........|.|.      |..:.|:..:  .
Human  1283 SLVAGKALSSARMSDAVLSQSSLM------GSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSS 1341

  Fly  1348 CKPTT 1352
            |.|:|
Human  1342 CYPST 1346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 184/251 (73%)
S_TKc 141..392 CDD:214567 184/250 (74%)
SIK3NP_001353615.1 STKc_SIK 65..317 CDD:270973 184/251 (73%)
UBA_SIK3 346..390 CDD:270593 21/46 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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