DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik2 and Mark4

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_758483.1	Gene:	Mark4 / 232944	MGIID:	1920955	Length:	752	Species:	Mus musculus

Alignment Length:	699	Identity:	260/699 - (37%)
Similarity:	360/699 - (51%)	Gaps:	138/699 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 SGGGSTPGPSPTSSAVGA---GGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKN 165
            ||..|..|||.:|.::||   ..|:...    :|...||.|.:.|||||||||.||||||.:|..
Mouse    23 SGRSSDKGPSWSSRSLGARCRNSIASCP----EEQPHVGNYRLLRTIGKGNFAKVKLARHILTGR 83

  Fly   166 EVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIA 230
            |||||||||:||:.::|||::|||.|||.|.||:|:||::|:||:..:|:|.||||.||:|||:.
Mouse    84 EVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLV 148

  Fly   231 KYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLA 295
            .:|||.|..||.||.||:|||.|||:|.||||||||||||||...|||||||||||.|..|..|.
Mouse   149 SHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213

  Fly   296 TWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFF 360
            |:||||||||||:|:||:|.|||:|||||||:||.||.|:|||||..|:.||:|||.|::|:||:
Mouse   214 TFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFY 278

  Fly   361 MSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNL---GAERQTSVEPSEDI- 421
            ||::||.::||.|||.|.:|.|::||.:.:|:             |:   |.|.:...||.||.
Mouse   279 MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI-------------NIGYEGEELKPYTEPEEDFG 330

  Fly   422 ----LRIMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSA 480
                :.:|   ||:|  .::.:.:|....|:.|.|.||||    ..|.|:....||..||  .:.
Mouse   331 DTKRIEVM---VGMGYTREEIKEALTNQKYNEVTATYLLL----GRKTEEGGDRGAPGLA--LAR 386

  Fly   481 SRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPG 545
            .|....:.|....::..|..:.:..|:|:       :.|..||        :...|     |.|.
Mouse   387 VRAPSDTTNGTSSSKGSSHNKGQRASSST-------YHRQRRH--------SDFCG-----PSPA 431

  Fly   546 PGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRV 610
            | .:.|..|                .:.|..|:....:|             ...::||:..|
Mouse   432 P-LHPKRSP----------------TSTGDTELKEERMP-------------GRKASCSAVGS-- 464

  Fly   611 GRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTIS---- 671
            |...|..|||        .:|..:||:.|.                  :|...|....|.:
Mouse   465 GSRGLPPSSP--------MVSSAHNPNKAE------------------IPERRKDSTSTPNNLPP 503

  Fly   672 EFIIKQSTEDC--RALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGE 734
            ..:.:::|..|  |...::.:.:..||::    .|....|||   .:|:|.:..|.||..  ...
Mouse   504 SMMTRRNTYVCTERPGSERPSLLPNGKEN----SSGTSRVPP---ASPSSHSLAPPSGER--SRL 559

  Fly   735 INGKTIK-TMSSSSSFDSKANLGQSFRYKMSAEASKLFQTL--QESPLP 780
            ..|.||: |.......|.:|..|.....:....||   .||  :.:|||
Mouse   560 ARGSTIRSTFHGGQVRDRRAGSGSGGGVQNGPPAS---PTLAHEAAPLP 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	161/251 (64%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	161/250 (64%)
Mark4	NP_758483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		6/12 (50%)
		STKc_MARK	58..310	CDD:270974	161/251 (64%)
		S_TKc	59..310	CDD:214567	161/250 (64%)
		UBA_MARK3_4	328..370	CDD:270590	13/48 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..615		60/311 (19%)
		MARK4_C	654..752	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810