Protein Alignment Sik2 and SIK2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_056006.1
• Gene: SIK2 / 23235
• HGNCID: 21680
• Length: 926
• Species: Homo sapiens
• Alignment Length: 1325
• Identity: 404/1325 - (30%)
• Similarity: 529/1325 - (39%)
• Gaps: 484/1325 - (36%)

  Fly   135 PMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPH 199
            |:||||||||.|:||||||||||.||||||.|||||||||||||..||:|:||||:|||.|.|||
Human    14 PVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPH 78

  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDL 264
            |||||||||||:|:|:|:|||..||||||:|.:||::||.||.|||||:|||:|||.:.||||||
Human    79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDL 143

  Fly   265 KAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLY 329
            ||||||||.|||||||||||.|.||.|||||||||||||||||||||:||.||::||||:|||||
Human   144 KAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLY 208

  Fly   330 VLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCP 394
            |||||||||||.||..||.|||.||||||:|||.:|||||||||||:|::|.||.|||.|:||..
Human   209 VLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLI 273

  Fly   395 EL-LEHVLIAKYNLGAERQTSV-EPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQD 457
            |: ::..::  |....|.:.|: |.:|.:||:| ..:||...||..||:..:|:|.||||.||.:
Human   274 EVPVQRPVL--YPQEQENEPSIGEFNEQVLRLM-HSLGIDQQKTIESLQNKSYNHFAAIYFLLVE 335

  Fly   458 RV-SHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQ---SQQQSKTISTSSILAKDQCHK 518
            |: ||:..                           .|.:|:   .|::..||:..::
Human   336 RLKSHRSS---------------------------FPVEQRLDGRQRRPSTIAEQTV-------- 365

  Fly   519 RLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGI 583
              ::.|||                               .||:|.||
Human   366 --AKAQTV-------------------------------GLPVTMHS------------------ 379

  Fly   584 PLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMME 648
                                                                |::..||...:.:
Human   380 ----------------------------------------------------PNMRLLRSALLPQ 392

  Fly   649 AGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPA 713
            |..  |.|...|.:..|......|       |:|              .|.||....:....||.
Human   393 ASN--VEAFSFPASGCQAEAAFME-------EEC--------------VDTPKVNGCLLDPVPPV 434

  Fly   714 STTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESP 778
            ..         ..|....|                                   |.:.:|
Human   435 LV---------RKGCQSLP-----------------------------------SNMMET----- 450

  Fly   779 LPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCET--DQGNDPG 841
                                                            |.|||.||  :...||.
Human   451 ------------------------------------------------SIDEGLETEGEAEEDPA 467

  Fly   842 SASQESKGSNGGGSGNANGGPTSHSSSDLT-RLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSY 905
            .|.:..:        :...|...|:.|::| :||                      |:.|:...:
Human   468 HAFEAFQ--------STRSGQRRHTLSEVTNQLV----------------------VMPGAGKIF 502

  Fly   906 SKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLAT-PTPASASPAGISSEHSS 969
            |.:.|.:|....|:.:.......|:|...:     ||.  ...|||. |:|...||. ||..
Human   503 SMNDSPSLDSVDSEYDMGSVQRDLNFLEDN-----PSL--KDIMLANQPSPRMTSPF-ISLR--- 556

  Fly   970 ERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRASDG 1034
                                           || ||...........:..|||:.|||||||||.
Human   557 -------------------------------PT-NPAMQALSSQKREVHNRSPVSFREGRRASDT 589

  Fly  1035 LVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHSHPHAHQHPHQHPHPH 1099
            .:.||:::          :..:....|:..|.||:.::|.|.::  :|         |...|:..
Human   590 SLTQGIVA----------FRQHLQNLARTKGILELNKVQLLYEQ--IG---------PEADPNLA 633

  Fly  1100 PQAYGLEELC-QFPNGQ-------FYALPGKHHPLLTLPHHHAHPAQH---HHGHHSLFHSGHQA 1153
            |.|..|::|. ..|..:       ...||...||.|:       |.|.   .:..|.|     |.
Human   634 PAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLS-------PRQSLETQYLQHRL-----QK 686

  Fly  1154 TPLLLEAAAGGDMYGHGCYAPPPPPPGLYTHHQLGVGMAVPMSPMQKPPLQQQLLQHRLLQQKRQ 1218
            ..||.:|.....:|   |..||                         ..|:|||.:|| |||||.
Human   687 PSLLSKAQNTCQLY---CKEPP-------------------------RSLEQQLQEHR-LQQKRL 722

  Fly  1219 LFQKQYALEAQLAGRHHHHQQHSHHHHHHFGHSL-----GPPPPPAPAPEHHLADELYELALLDR 1278
            ..|||..|:|     :.:..|.:...:......|     ..|||...||...|...|..:.   .
Human   723 FLQKQSQLQA-----YFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVL---E 779

  Fly  1279 PRSGTPRLQHSMTMPGAHAFSQMNLK---------------TSYISQSDQVPGAAPNGAGSGGSA 1328
            |.|  .::|:|   |....:.:|.|:               |....|....|...|.....|.:.
Human   780 PSS--EQMQYS---PFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAP 839

  Fly  1329 AGV-----SCSAP--PSTAPGTPTVKCK-------------PTTPHGHSLDSDYHTSTPVLSLFT 1373
            |.:     :|..|  .|.||..|| .|:             |..|....|.....:..|:
Human   840 APLQFSYQTCELPSAASPAPDYPT-PCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPL----- 898

  Fly  1374 PNWQSLVKPLSESPILEISEHLESV 1398
                    .|||.|.|...|.|::|
Human   899 --------ALSELPGLFDCEMLDAV 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	198/251 (79%)
		UBA_SIK	418..458	CDD:270523	18/39 (46%)
SIK2	NP_056006.1	STKc_SIK	19..271	CDD:270973	198/251 (79%)
		UBA_SIK2	297..341	CDD:270592	20/44 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..666		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..776		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..896		17/95 (18%)