DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik2 and PASK

DIOPT Version :10

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:NP_001239048.1 Gene:PASK / 23178 HGNCID:17270 Length:1330 Species:Homo sapiens


Alignment Length:488 Identity:136/488 - (27%)
Similarity:214/488 - (43%) Gaps:87/488 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 AAAAGENGSQAKSEESQPPEDQKKKQPQHERNEKQLDKPPENLPQNGKTEAKGAE---------G 61
            ||:..|:.....|.....|||   ..|..|  |.:|:....:.|......|.|.:         |
Human   837 AASDRESPGHVPSTLDAGPED---TCPSAE--EPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSG 896

  Fly    62 ACSHPPLDALRSSVLLDAGAASPSIDAIVAC----KDALLAQ-------KLFASGGGSTPGPSPT 115
            :|.|  .|.||.|:..:...........:.|    ||.|.:|       :||.:   |.|| |..
Human   897 SCYH--RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLA---SLPG-STH 955

  Fly   116 SSAVGAGGISGKDLLK----LKEPMRV----GF----------YDIERTIGKGNFAVVKLARHRI 162
            |:|....|.|..::|:    .:||.:.    |.          |.....:|.|.|..|..|..:.
Human   956 STAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 1020

  Fly   163 TKNEVAIKIIDKSQ------LDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYAS 221
            ...||.:|.|.|.:      ::...|.||..|:.|:.|::|.:|||:..:.|.:....:|.|...
Human  1021 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHG 1085

  Fly   222 QG-EIFDYIAKYGRMSESAARFKFWQI-------ISAVEYCHKKGIVHRDLKAENLLLDLNMNIK 278
            .| ::|.:|.::.|:.|..|.:.|.|:       :|||.|...|.|:|||:|.||:::..:..||
Human  1086 SGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIK 1150

  Fly   279 IADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTL 343
            :.|||.:.:.:.|:|..|:||:..|.||||..|..|.|||:::|||||.||.||     |:.:..
Human  1151 LIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLV-----FEENPF 1210

  Fly   344 QSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLG 408
            ..|.:.| ......|:.:|.|...|:..:|...|.||.|::::....|    :.:.|.:|.|.. 
Human  1211 CELEETV-EAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPW----VTQPVNLADYTW- 1269

  Fly   409 AERQTSVEPSEDILRIMAEYVGIGSDKTRASLK 441
                      |::.|:.....|:.|   .|||:
Human  1270 ----------EEVFRVNKPESGVLS---AASLE 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 85/275 (31%)
UBA_SIK 418..458 CDD:270523 7/24 (29%)
PASKNP_001239048.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..47
PAS 133..232 CDD:238075
PAS 344..401 CDD:214512
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 837..857 5/19 (26%)
STKc_PASK 998..1258 CDD:270906 86/269 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1305..1330
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.