DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik2 and Mark1

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001365805.1	Gene:	Mark1 / 226778	MGIID:	2664902	Length:	796	Species:	Mus musculus

Alignment Length:	769	Identity:	266/769 - (34%)
Similarity:	377/769 - (49%)	Gaps:	166/769 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 EPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHP 198
            |...:|.|.:::||||||||.||||||.:|..|||:|||||:||:.|:|||::|||.|||.|.||
Mouse    53 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 117

  Fly   199 HIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRD 263
            :|:||::|:||:..:|:|.||||.||:|||:..:|||.|..||.||.||:|||:|||:|.|||||
Mouse   118 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRD 182

  Fly   264 LKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVL 328
            |||||||||.:||||||||||||.|..|..|.|:||||||||||:|:||:|.|||:|:|||||:|
Mouse   183 LKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 247

  Fly   329 YVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMC 393
            |.||.|:|||||..|:.||:|||.|::||||:||::||:|::::|||.|.:|.:::||.:.|||
Mouse   248 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM- 311

  Fly   394 PELLEHVLIAKYNLGAERQ---TSVEPSEDI-----LRIMAEYVGIGSDKTRASLKKNTYDHVAA 450
                        |:|.|.:   ...||..|:     :.||.. :|...|:...:|....||.|.|
Mouse   312 ------------NVGHEEEELKPYSEPELDLSDAKRIDIMVT-MGFARDEINDALVSQKYDEVMA 363

  Fly   451 IYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQ 515
            .|:|| .|...:.|....|.:.:|.                     |..:.|..::.|::  :..
Mouse   364 TYILL-GRKPPEFEGGESLSSGSLC---------------------QRSRPSSDLNNSTL--QSP 404

  Fly   516 CHKRLSRHQTVLMSER--NAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHS------------H 566
            .|.::.|..:....:|  :.|||  |::| |...|..:      |...:..|            .
Mouse   405 AHLKVQRSISANQKQRRFSDHAG--PSIP-PAVSYTKR------PQANSVESEQKEEWGKDTARR 460

  Fly   567 LTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSN---------------CSSTSSRV-----G 611
            |.....|...||.||.:..|.|     ..::.:|||               |..::.|.     |
Mouse   461 LGSTTVGSKSEVTASPLVGPDR-----KKSTASPSNNVYSGGSMARRNTYVCERSTDRYAALQNG 520

  Fly   612 RHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPV------------------GAVG 658
            |.|..:....|....|.|......|| |..|.::.|...|.|:                  .|..
Mouse   521 RDSSLTEMSASSMSSAGSTVASAGPS-ARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGSAAQR 584

  Fly   659 VPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTT-PTSSTA 722
            ||.||...|.      |..||.|.....:.|::.:....:..:...|.....||||.: .|.:.|
Mouse   585 VPAASPSAHS------ISASTPDRTRFPRGSSSRSTFHGEQLRERRSAAYNGPPASPSHETGAFA 643

  Fly   723 GPESGSA---------------PCPGEINGKTIKTMSSS------SSFDSKANLGQSFRYKMSAE 766
            ....|::               |..||.:|:......||      ...:.|....:|.|:..|.:
Mouse   644 HARRGTSTGIISKITSKFVRRDPSEGEASGRADTARGSSGDPKERDKDEGKEAKPRSLRFTWSMK 708

  Fly   767 AS----------KLFQTLQESPLPVEQRTKRR-----VHVGSTNGSGGDSGQET 805
            .:          ::.:.|..:....||  |.|     ||        ||:.|::
Mouse   709 TTSSMDPNDMLREIRKVLDANTCDYEQ--KERFLLFCVH--------GDARQDS 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	160/251 (64%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	160/250 (64%)
Mark1	NP_001365805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		STKc_MARK	59..311	CDD:270974	160/251 (64%)
		UBA_like_SF	331..371	CDD:419673	12/41 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..498		28/157 (18%)
		MARK1-3_C	697..794	CDD:213381	13/66 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810