Protein Alignment Sik2 and Snrk

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_598502.2
• Gene: Snrk / 20623
• MGIID: 108104
• Length: 748
• Species: Mus musculus
• Alignment Length: 937
• Identity: 258/937 - (27%)
• Similarity: 383/937 - (40%)
• Gaps: 240/937 - (25%)

  Fly   139 GFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKL 203
            |.||:::|:|:|:|||||||||..|..:||:|:|||::||......:::||..||.::||:|::|
Mouse    14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRL 78

  Fly   204 YQVMETKNMIYIVSEYASQGEIFDYIAKYGR-MSESAARFKFWQIISAVEYCHKKGIVHRDLKAE 267
            |:|::|:..:|::.|....|::||||.|:.. ::|..|:..|.||:.|:.||||..:||||||.|
Mouse    79 YEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPE 143

  Fly   268 NLL-LDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVL 331
            |:: .:....:|:.||||||.|:||:.|.|.|||..|:|||:..|.:|..|.:|||||||:|::|
Mouse   144 NVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFML 208

  Fly   332 VCGALPF----DGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM 392
            |||..||    |..||..:.|    .::.:|..:|:.|..||.|||..:|.||.::::|:.|.|:
Mouse   209 VCGQPPFQEANDSETLTMIMD----CKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWL 269

  Fly   393 -----CPELLEHVLIAKY-NLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAI 451
                 .|....::.:..| ||..|...|:     |.|::...:. ..|....:|:.|.|:|:.|.
Mouse   270 QGVDPSPATKYNIPLVSYKNLSEEEHNSI-----IQRMVLGDIA-DRDAIVEALETNRYNHITAT 328

  Fly   452 YLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQC 516
            |.||.:|:..:|::......||..|:..|               |..|.....|.....|..|..
Mouse   329 YFLLAERILREKQEKEIQTRSASPSNIKA---------------QFRQSWPTKIDVPQDLEDDLT 378

  Fly   517 HKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDAS 581
            ...|| |.||..|.  |.||..                     .|.||.              :.
Mouse   379 ATPLS-HATVPQSP--ARAGDN---------------------VLNGHR--------------SK 405

  Fly   582 GIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREM 646
            |:..|.:...||..|.||               ||:..|.|.:|.|           :..:|...
Mouse   406 GLCDPAKKDELPELAGPA---------------LSTVPPASMKPAA-----------SGRKCLFR 444

  Fly   647 MEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPP 711
            :|...                        ::..||.:.:...:..|...|
Mouse   445 VEEDE------------------------EEDEEDKKPVSLSTQVVLRRK--------------- 470

  Fly   712 PASTTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSF-RYKMSAEASKLFQTLQ 775
            |:.|...:|..     |||...:|    .:...|...||...||.... |.||:.
Mouse   471 PSVTNRLTSRK-----SAPVLNQI----FEEGESDDEFDMDENLPPKLSRLKMNI---------- 516

  Fly   776 ESPLPVEQRTKRRVHVGSTNGSGGD-SGQETNDAKSNGDSRSEK------KVLAQGSSSTDEGCE 833
            .||..|.:|..||    .:.|.|.. |..||:|..|....|.:|      ....:.||....|.|
Mouse   517 ASPGTVHKRYHRR----KSQGRGSSCSSSETSDDDSESRRRLDKDSGFAYSWHRRDSSEGPPGSE 577

  Fly   834 TDQGNDPGSASQESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVL 898
            .|.|.       :||.|:|||...|:.|...             |.|        .|...|.|..
Mouse   578 GDGGG-------QSKPSSGGGVDKASPGEQG-------------TGG--------GSQGGSGGTP 614

  Fly   899 AGSAGSYSKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPS------CMGS----SSMLATP 953
            :|:|||         ||..:..:.|.|..:...|.|.|...:.|      |:||    :..:..|
Mouse   615 SGTAGS---------SRRCAGPDSSSPSPASASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDP 670

  Fly   954 TPASASPAGISSEHSSERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLD 1018
            ..|.     .||....|:|.:   ..||..||..|       |:...|........|...:...:
Mouse   671 QKAL-----FSSVKVQEKSTW---KMCISAPGPSP-------SADLDPVRTKKLRNNALQLPLCE 720

  Fly  1019 KRSPIHFREGRRASDGLVAQGLLSSGS 1045
            |...::.:..|:       :|||.:.|
Mouse   721 KTISVNIQRSRK-------EGLLCASS 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	113/257 (44%)
		UBA_SIK	418..458	CDD:270523	11/39 (28%)
Snrk	NP_598502.2	STKc_SNRK	12..269	CDD:270976	114/258 (44%)
		UBA_SNRK	288..335	CDD:270524	15/52 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..415		13/69 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..640		50/199 (25%)