DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and MARK2

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	XP_011543091.1	Gene:	MARK2 / 2011	HGNCID:	3332	Length:	808	Species:	Homo sapiens

Alignment Length:	829	Identity:	293/829 - (35%)
Similarity:	415/829 - (50%)	Gaps:	155/829 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PLDALRSSVLLDAGAASPSIDAIVACKDALLAQKLFASGGGSTPG-----PSPTSSAV-GAGGIS 125
            |...|:|...|...|..|::..|:..:         ..|.|.|.|     ||..|:.: |....:
Human     7 PFPFLQSVACLLTLAHIPAVGNILQHR---------RRGAGPTLGHLDSKPSSKSNMIRGRNSAT 62

  Fly   126 GKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVE 190
            ..|     |...:|.|.:.:||||||||.||||||.:|..|||:|||||:||:.::|||::|||.
Human    63 SAD-----EQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 122

  Fly   191 IMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCH 255
            |||.|.||:|:||::|:||:..:|:|.||||.||:|||:..:|||.|..||.||.||:|||:|||
Human   123 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 187

  Fly   256 KKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEID 320
            :|.||||||||||||||.:||||||||||||.|..|..|.|:||||||||||:|:||:|.|||:|
Human   188 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 252

  Fly   321 IWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQ 385
            :|||||:||.||.|:|||||..|:.||:|||.|::||||:||::||:|:::.|:|.|::|.|::|
Human   253 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 317

  Fly   386 IKRHRWMCPELLEHVLIAKYNLG---AERQTSVEPSEDI-----LRIMAEYVGIGSDKTRASLKK 442
            |.:.|||             |:|   .|.:..|||..|.     ..:|.. :|...::.:.||..
Human   318 IMKDRWM-------------NVGHEDDELKPYVEPLPDYKDPRRTELMVS-MGYTREEIQDSLVG 368

  Fly   443 NTYDHVAAIYLLL--------QDRVSHKKEQSNGL-GASALASSTSASRMIYSSRNDHQPTQQQS 498
            ..|:.|.|.||||        .|.::.|...|..| .:||.:.|....|.:.::     |.|::.
Human   369 QRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSAN-----PKQRRF 428

  Fly   499 QQQS--KTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVP-DPGPGYYAKYGPLQLPLP 560
            ..|:  ..|.||:..:|..........:.....|....|.:|..|| .|.||...|   ...|.|
Human   429 SDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERK---KTTPTP 490

  Fly   561 LTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAAS-------------PAPSNCSSTSSRVGR 612
            .| :|.|:...|..             |.:||...||             ..|.:.:||:|  ..
Human   491 ST-NSVLSTSTNRS-------------RNSPLLERASLGQASIQNGKDSLTMPGSRASTAS--AS 539

  Fly   613 HSLSSSSPRSHRPVAISLSIDNN------PSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTIS 671
            .::|::.||.|:. ::|.|:..|      |:.:|  | |:......|   ..||:||...|...|
Human   540 AAVSAARPRQHQK-SMSASVHPNKASGLPPTESN--C-EVPRPSTAP---QRVPVASPSAHNISS 597

  Fly   672 EFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEIN 736
            .......|...|.:..:||..| |:....:.:.::     |...|| :|.:|...|.....|.|.
Human   598 SGGAPDRTNFPRGVSSRSTFHA-GQLRQVRDQQNL-----PYGVTP-ASPSGHSQGRRGASGSIF 655

  Fly   737 GK-TIKTMSSSSSFD-SKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSGG 799
            .| |.|.:..:.||. ::.||.:       .|:....:||             |.||   .||||
Human   656 SKFTSKFVRRNLSFRFARRNLNE-------PESKDRVETL-------------RPHV---VGSGG 697

  Fly   800 D-------------------SGQETNDAKSNGDSRSEKKVLAQGSSSTD 829
            :                   |.:.|:..:.|...|..:|||...|..::
Human   698 NDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSE 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	159/251 (63%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	159/250 (64%)
MARK2	XP_011543091.1	STKc_MARK	72..324	CDD:270974	159/251 (63%)
		S_TKc	73..324	CDD:214567	159/250 (64%)
		UBA_MARK2	342..383	CDD:270589	12/41 (29%)
		MARK2_C	709..807	CDD:213386	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810