Protein Alignment Sik2 and Y43D4A.6

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_502989.1
• Gene: Y43D4A.6 / 189855
• WormBaseID: WBGene00012792
• Length: 328
• Species: Caenorhabditis elegans
• Alignment Length: 259
• Identity: 82/259 - (31%)
• Similarity: 141/259 - (54%)
• Gaps: 14/259 - (5%)

  Fly   145 RTIGKGNFAVV----KLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQ 205
            ::||||.|..|    ||...||   :||:|.|:.....:..|:::.:|..|.|.:||.:|:|:|.
 Worm    10 KSIGKGAFGQVFLAEKLNNPRI---KVAMKKINIFGAPKEFLEQIQQEYYIQKNMKHKNIVKMYG 71

  Fly   206 VMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLL 270
            :.......|:..|:.:.|::|:.|.....|..:..:....|::|.::|.|..||||||:|.:|||
 Worm    72 MSMDTEFCYLFQEFVTGGDLFEKIDFENGMPVNQVKGYLKQLMSGLKYIHGCGIVHRDIKPDNLL 136

  Fly   271 LDLNMNIKIADFGFSNHFKPGE---LLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLV 332
            ::.:..:||||||.|..|...:   ||....|:.|:.|||:|..|::.||.:||||.|::::.|:
 Worm   137 INSSDALKIADFGLSTRFIVDDKEILLHERIGTTPFMAPELFAKKKHRGPPVDIWSAGILVFSLL 201

  Fly   333 CGALPFD----GSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM 392
            .|.||:|    ...|.|......:.:..|.:.:|:.....::::|......|.||::|:...|:
 Worm   202 TGNLPWDEPKESDILYSQWMNNKTSKNCIWYGLSTPVVRFLKKLLKENVNERATIEEIESDPWL 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	81/257 (32%)
		UBA_SIK	418..458	CDD:270523
Y43D4A.6	NP_502989.1	STKc_Chk1	4..265	CDD:270971	81/257 (32%)