Protein Alignment Sik2 and tag-344

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_492786.1
• Gene: tag-344 / 182017
• WormBaseID: WBGene00015230
• Length: 367
• Species: Caenorhabditis elegans
• Alignment Length: 260
• Identity: 94/260 - (36%)
• Similarity: 149/260 - (57%)
• Gaps: 17/260 - (6%)

  Fly   144 ERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVY------REVEIMKRLKHPHIIK 202
            |:.:|.|:::.|..|.....|.|||.|||:   :..|..::.|      ||.||:|.|||.:|.:
 Worm    72 EKVLGSGSYSRVARATFGEKKLEVAAKIIN---ITPTREKEDYIKKFLPREKEIVKLLKHDNICR 133

  Fly   203 LYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAE 267
            ||:::..::.|..|:||.:.|::...:.....|.|..|:|.|.|:|:|:.:.....|||||||.|
 Worm   134 LYEMISFQDHIIFVNEYCAGGDLLRKMKDIVAMKEEDAKFTFRQLIAALTHLQSYNIVHRDLKCE 198

  Fly   268 NLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLV 332
            |:.:|.:.|:|:.|||||...||||...|:|||..|.|||:|.|::|:|..:|:||.||:||:::
 Worm   199 NIFMDKHGNVKLGDFGFSRILKPGEKSGTFCGSRAYVAPEIFRGREYSGNAVDVWSTGVILYIML 263

  Fly   333 CGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLE-----PTRRYTIDQIKRHRWM 392
            .|::|||....:.:.:|.|:.:.:.|...:|.   :..:.||||     ...|.|...|....|:
 Worm   264 AGSMPFDDRDPRKMIERQLAHKIKFPKSCTSS---VFSKALVLEILQPHAPNRPTYKAICESEWL 325

  Fly   393  392
             Worm   326  325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	93/258 (36%)
		UBA_SIK	418..458	CDD:270523
tag-344	NP_492786.1	Protein Kinases, catalytic domain	71..325	CDD:473864	93/258 (36%)