Protein Alignment Sik2 and aak-2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_510710.2
• Gene: aak-2 / 181727
• WormBaseID: WBGene00020142
• Length: 626
• Species: Caenorhabditis elegans
• Alignment Length: 647
• Identity: 196/647 - (30%)
• Similarity: 301/647 - (46%)
• Gaps: 121/647 - (18%)

  Fly    97 LAQKLFASG------GGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVV 155
            |::||.|..      ..||...|..||.  .|..|.|...:||..:::|.|.::.|:|.|.|..|
 Worm    39 LSRKLSAKSRKERKDRDSTDNSSKMSSP--GGETSTKQQQELKAQIKIGHYILKETLGVGTFGKV 101

  Fly   156 KLARHRITKNEVAIKIIDKSQLDQTN-LQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEY 219
            |:..|..|:.:||:||:::.::...: :.|:.||::.:...:|||||:||||:.|.:.|:::.|:
 Worm   102 KVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQVISTPSDIFMIMEH 166

  Fly   220 ASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGF 284
            .|.||:||||.|:||:..:.||..|.||||.|:|||:..:||||||.||||||...|:||||||.
 Worm   167 VSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDEQNNVKIADFGL 231

  Fly   285 SNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDR 349
            ||....|:.|.|.||||.||||||..||.|.|||:|:||.||:||.|:||.||||...:.||..:
 Worm   232 SNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPSLFRK 296

  Fly   350 VLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTS 414
            :.||.|..|.|:.....:|:..||.::|.:|.||..:..|.|...: |.:.|....|........
 Worm   297 IKSGVFPTPDFLERPIVNLLHHMLCVDPMKRATIKDVIAHEWFQKD-LPNYLFPPINESEASIVD 360

  Fly   415 VEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQD--RVS-----------HKKEQS 466
            :|...::......:|. ..:.|.|.|..:.:.|::..|.|:.|  |::           ::...:
 Worm   361 IEAVREVTEFQRYHVA-EEEVTSALLGDDPHHHLSIAYNLIVDNKRIADETAKLSIEEFYQVTPN 424

  Fly   467 NGLG---------ASALAS-------STSASRMIYSSRND----HQPTQQQSQQQSKTISTSSIL 511
            .|.|         |::::|       :|.||.   ::||.    |...:.||:.:.........:
 Worm   425 KGPGPVHRHPERIAASVSSKITPTLDNTEASG---ANRNKRAKWHLGIRSQSRPEDIMFEVFRAM 486

  Fly   512 AK-DQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGG 575
            .: |...|.|:.:..::..:.:|.|...|.:            .|||
 Worm   487 KQLDMEWKVLNPYHVIVRRKPDAPAADPPKM------------SLQL------------------ 521

  Fly   576 VEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPR----------SHRPVAISL 630
            .:||.....|..:        |.|.....|.|:...||: |.|.|:          |..|.|:|:
 Worm   522 YQVDQRSYLLDFK--------SLADEESGSASASSSRHA-SMSMPQKPAGIRGTRTSSMPQAMSM 577

  Fly   631 SIDNNPSLANLRCREMMEAG------GGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALL 686
                ..|:..:...:..:..      ..|.||        :|.||:..|      |.|.||:
 Worm   578 ----EASIEKMEVHDFSDMSCDVTPPPSPGGA--------KLSQTMQFF------EICAALI 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	118/252 (47%)
		UBA_SIK	418..458	CDD:270523	8/41 (20%)
aak-2	NP_510710.2	STKc_AMPK_alpha	84..339	CDD:270981	119/254 (47%)
		UBA_AID_AMPKalpha	356..419	CDD:270521	10/63 (16%)
		AMPKA_C	462..624	CDD:213378	40/217 (18%)