Protein Alignment Sik2 and prk-2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_497696.2
• Gene: prk-2 / 175437
• WormBaseID: WBGene00004183
• Length: 441
• Species: Caenorhabditis elegans
• Alignment Length: 458
• Identity: 119/458 - (25%)
• Similarity: 201/458 - (43%)
• Gaps: 97/458 - (21%)

  Fly   123 GISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQ---TNLQK 184
            |.|.:...|.|:.     |.::..:|:|.|.||..|........||:|.|::|.:.:   .|.::
 Worm    18 GESSRGFSKFKKN-----YKLKAELGRGGFGVVYRAVRTCDNALVAVKFIERSNVKEWARINGEQ 77

  Fly   185 VYREV-EIMKRLKHPHIIKL---YQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFW 245
            |..|: .:.|..|...:|:|   |.:.|  ..:.::.......::||:|...|::||..|||.|.
 Worm    78 VPMEICMLAKCSKVRGVIRLLDWYSIPE--GFLIVMERPYPCIDMFDFIKGQGKISEDMARFLFR 140

  Fly   246 QIISAVEYCHKKGIVHRDLKAENLLLDL-NMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVF 309
            ||...|..|.:..::|||||.||:::|| ..:.|:.|||.:...:..: .:.:.|:..|..||.|
 Worm   141 QIAVTVHECVQNRVLHRDLKDENIVIDLVTGSTKLIDFGAATVLRRSQ-YSDFQGTRLYCPPEWF 204

  Fly   310 EGKQYTGPEIDIWSLGVVLYVLVCGALPF----DGSTLQSLRDRVLSGRFRIPFF--MSSECEHL 368
            ....|.|.|..:|||||:||..:.|.|||    |..|...|..        :|||  :|:|.:.|
 Worm   205 LHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAHLLGP--------LPFFVPVSAEVKDL 261

  Fly   369 IRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGS 433
            |.:.|..:|.:|.:::.|..|.|:..:.|....:.|..:  :::|| |.|:|   ..:|.:|..|
 Worm   262 ISKCLTFDPFQRCSLEAILNHPWVKQQTLSWDALTKNKV--QKKTS-ESSDD---HHSETLGDHS 320

  Fly   434 DKTRASLKKNTYDHVAAIYLLLQDR---VSHKKEQ----SNGLGASALASSTSASRMIYSSRNDH 491
            :..                   :||   .|...:|    ..|:|.||.:|:|         .|..
 Worm   321 ETE-------------------EDRSPPTSSVSQQPGSADEGVGLSASSSNT---------HNQK 357

  Fly   492 QPTQQQ-------------------SQQQSKTISTSSILAKDQCHKRLSRH-------QTVLMSE 530
            :|..::                   :.|.|||.:..::....:..:::.:|       .|||.:.
 Worm   358 KPNHKEFRMAKTSLLAPPTSIEMKAAVQASKTPTQFNVHTALKNQRQIKKHHSPQPPNSTVLTAL 422

  Fly   531 RNA 533
            |.|
 Worm   423 RRA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	82/265 (31%)
		UBA_SIK	418..458	CDD:270523	5/39 (13%)
prk-2	NP_497696.2	STKc_PIM	30..285	CDD:270907	82/270 (30%)