DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and Mark3

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	XP_006515574.1	Gene:	Mark3 / 17169	MGIID:	1341865	Length:	806	Species:	Mus musculus

Alignment Length:	755	Identity:	279/755 - (36%)
Similarity:	384/755 - (50%)	Gaps:	127/755 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GPSPTSSAVGAGGISGKDLLK--LKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIID 173
            |....:|..|..|...::.:.  ..|...:|.|.:.:||||||||.||||||.:|..||||||||
Mouse    24 GRQEVTSRTGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIID 88

  Fly   174 KSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSES 238
            |:||:.|:|||::|||.|||.|.||:|:||::|:||:..:|::.||||.||:|||:..:|||.|.
Mouse    89 KTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEK 153

  Fly   239 AARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPY 303
            .||.||.||:|||:|||:|.||||||||||||||.:||||||||||||.|..|..|.|:||||||
Mouse   154 EARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPY 218

  Fly   304 AAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHL 368
            ||||:|:||:|.|||:|:|||||:||.||.|:|||||..|:.||:|||.|::||||:||::||:|
Mouse   219 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENL 283

  Fly   369 IRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAER---QTSVEPSEDI-----LRIM 425
            ::|.|||.|.:|.|::||.:.||:             |.|.|.   :..|||..||     :.||
Mouse   284 LKRFLVLNPVKRGTLEQIMKDRWI-------------NAGHEEDELKPFVEPELDISDQKRIDIM 335

  Fly   426 AEYVGIG--SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGA-----------SALASS 477
               ||:|  .::.:.||.|..||.:.|.|||| .|.|.:.:.|:...:           |.|::|
Mouse   336 ---VGMGYSQEEIQESLSKMKYDEITATYLLL-GRKSAELDASDSSSSSNLSLAKVRPNSDLSNS 396

  Fly   478 TSAS------RMIYSSR-----NDHQ----PTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVL 527
            |..|      |.:.||:     :||.    |:.....::|:|.:..|.|.:|....|.|....|
Mouse   397 TGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGIPSRKSSSSAV- 460

  Fly   528 MSERNAHAGATPTVPDPGPGYYA-----KYGPLQLPLPLTGHSHLT---GYLNGGGVEVDASGIP 584
              .....|.|:|.:.:.|....|     |..| .:|...|....:|   .|:.......|...:.
Mouse   461 --GGKGIAPASPMLGNAGNPNKADIPERKKSP-AVPSSNTASGGMTRRNTYVCSERCAADRHSVI 522

  Fly   585 LPMRYTPLPT----AASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCRE 645
            ...:...|..    ||||| |.|::::.|: ||..|.|...|..|..:...||:.
Mouse   523 QNGKENSLTEVFAYAASPA-SLCATSTCRL-RHQRSMSVSASGHPKMVLPPIDSE---------- 575

  Fly   646 MMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVP 710
                 |....|:.:|.....:..|.|   |..:|...|....:.||........|:...:.....
Mouse   576 -----GDTFKAIAIPDERTPVASTHS---ISSATTPDRIRFPRGTASRSTFHGQPRERRTATYNG 632

  Fly   711 PPAS------TTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASK 769
            ||||      .||.|.|..            .|.| ...|..:|..::.|:  |||:
Mouse   633 PPASPSLSHEATPLSQTRS------------RGST-NLFSKLTSKLTRRNM--SFRF-------- 674

  Fly   770 LFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQETNDAK 809
                  ...||.|.....| :.||:.....:...|..:||
Mouse   675 ------IKRLPTEYERNGR-YEGSSRNVSSEQKDENREAK 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	162/251 (65%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	162/250 (65%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	162/251 (65%)
		UBA_MARK3_4	325..367	CDD:270590	17/45 (38%)
		MARK1-3_C	707..804	CDD:213381	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810