DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik2 and SIK1

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_775490.2	Gene:	SIK1 / 150094	HGNCID:	11142	Length:	783	Species:	Homo sapiens

Alignment Length:	935	Identity:	331/935 - (35%)
Similarity:	438/935 - (46%)	Gaps:	238/935 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTN 181
            ||..||...|:     ::|:||||||||||:||||||||||||||:||.:||||||||::||.:|
Human     8 SADPAGQGQGQ-----QKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN 67

  Fly   182 LQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQ 246
            |:|:||||::||.|.||||||||||||||:|:|||:|:|..||:|||:...|.:||:.||.||||
Human    68 LEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQ 132

  Fly   247 IISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEG 311
            |:|||||||...|||||||.||||||.||:||:|||||.|.:|.||.|:||||||||||||||||
Human   133 ILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEG 197

  Fly   312 KQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLE 376
            |:|.||::|||||||||||||||:|||||..|.:||.|||.||||||||||.:||.|||||||::
Human   198 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVD 262

  Fly   377 PTRRYTIDQIKRHRWM----------CPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGI 431
            |.||.||.||::||||          ||....|...:  |||       :..|..|.|| :.:|:
Human   263 PARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTS--NLG-------DYDEQALGIM-QTLGV 317

  Fly   432 GSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQ 496
            ...:|..||:.::|:|.||||.||.:|:   ||..|     |..:....:|         ||..:
Human   318 DRQRTVESLQNSSYNHFAAIYYLLLERL---KEYRN-----AQCARPGPAR---------QPRPR 365

  Fly   497 QS-----QQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQ 556
            .|     :...:.:||........|.:..:..|:||.:|.:....::                ||
Human   366 SSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSS----------------LQ 414

  Fly   557 LPL--PLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVG-------- 611
            .||  |               |:...||:     :.|.|.:.|.......|..:|.|
Human   415 WPLFFP---------------VDASCSGV-----FRPRPVSPSSLLDTAISEEARQGPGLEEEQD 459

  Fly   612 -RHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFII 675
             :.||.||:.|.|....:|..:.                          ||
Human   460 TQESLPSSTGRRHTLAEVSTRLS--------------------------PL-------------- 484

  Fly   676 KQSTEDCRALLQQSTA-VAEGKDDPPKAESSVGGVPPPASTTP-TSSTAGPESGSAPCPGEINGK 738
               |..|..:...:|| .|||.........|....|...|.|| |....|     |..|..:...
Human   485 ---TAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLG-----ACSPVRLASP 541

  Fly   739 TIKTMSSSSSFDSKANLG------QSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGS 797
            .:.:.|::....::..||      .||:....|..:.|.|.|:.....:.:.|:.:..:|..
Human   542 FLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLN--- 603

  Fly   798 GGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCETDQGNDPGSASQESKGSNGGGSGNANGGP 862
                       |..|.:|   :|....:|....|     |..|..|..:|.|.:||.:|:..|..
Human   604 -----------KIKGLAR---QVCQAPASRASRG-----GLSPFHAPAQSPGLHGGAAGSREGWS 649

  Fly   863 TSHSSSDLTRLVGTTTSGQSHKMRSYASSSS-----SSGVLAGSAGSYSKSLSQNLSRGSSKSNC 922
            ......:..||:..    |.|...:...|.:     :..|:|                     .|
Human   650 LLEEVLEQQRLLQL----QHHPAAAPGCSQAPQPAPAPFVIA---------------------PC 689

  Fly   923 SGPYDSLDFALPSGKGSLPSCMGSSSMLATPTP---ASASPAGISSEHSSERSLYGSHNSCIHMP 984
            .||          |...|||.:.:|.:...|.|   ..|||.      :|...|..:|
Human   690 DGP----------GAAPLPSTLLTSGLPLLPPPLLQTGASPV------ASAAQLLDTH------- 731

  Fly   985 GALPLGLGLPQSSASTPTPNPTPPP 1009
              |.:|.|        ||..|..||
Human   732 --LHIGTG--------PTALPAVPP 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	186/251 (74%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	185/250 (74%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	186/251 (74%)
		S_TKc	27..278	CDD:214567	185/250 (74%)
		UBA_SIK1	300..349	CDD:270591	22/59 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..377		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..477		8/27 (30%)
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305\|PubMed:29211348	583..612		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643		8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	421	1.000	Domainoid score	I628
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1352
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm41733
orthoMCL	1	0.900	-	-		OOG6_105552
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2250
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.820