Protein Alignment Sik2 and PIM2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_006866.2
• Gene: PIM2 / 11040
• HGNCID: 8987
• Length: 311
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 101/328 - (30%)
• Similarity: 158/328 - (48%)
• Gaps: 64/328 - (19%)

  Fly   109 TPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRIT-KNEVAIKII 172
            ||.|.|          .|||....:...|:|     ..:|||.|..| .|.||:| :.:||||:|
Human    15 TPTPPP----------GGKDREAFEAEYRLG-----PLLGKGGFGTV-FAGHRLTDRLQVAIKVI 63

  Fly   173 DKSQL-------DQTNLQKVYREVEIMKRL----KHPHIIKLYQVMETKNMIYIVSEYASQG-EI 225
            .::::       |.....   .||.::.::    .||.:|:|....||:....:|.|..... ::
Human    64 PRNRVLGWSPLSDSVTCP---LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDL 125

  Fly   226 FDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMN-IKIADFGFSNHFK 289
            ||||.:.|.:.|..:|..|.|:::|:::||.:|:||||:|.||:|:||... .|:.||| |....
Human   126 FDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALL 189

  Fly   290 PGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDR-VLSG 353
            ..|....:.|:..|:.||.....||......:||||::||.:|||.:||:       ||: :|..
Human   190 HDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFE-------RDQEILEA 247

  Fly   354 RFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPS 418
            ....|..:|.:|..||||.|..:|:.|.::::|....||                   ||   |:
Human   248 ELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM-------------------QT---PA 290

  Fly   419 EDI 421
            ||:
Human   291 EDV 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	85/266 (32%)
		UBA_SIK	418..458	CDD:270523	2/4 (50%)
PIM2	NP_006866.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		6/19 (32%)
		STKc_PIM2	31..287	CDD:271003	89/291 (31%)