Protein Alignment Sik2 and Smokwl5

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_038936416.1
• Gene: Smokwl5 / 102551633
• RGDID: 7576862
• Length: 474
• Species: Rattus norvegicus
• Alignment Length: 570
• Identity: 152/570 - (26%)
• Similarity: 244/570 - (42%)
• Gaps: 159/570 - (27%)

  Fly   131 KLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRL 195
            |.||......|.|...:|:|:|..|.||.|..|:..||||::   ::.:..:..:..|..|::.|
  Rat     4 KSKEKTLGSHYKILSYLGQGSFGTVNLAWHLKTQALVAIKML---EISKETISSILSERAILETL 65

  Fly   196 KHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIV 260
            .||:||:|:||:.|.:.:..|.|||..|.:|:.|.:.|.:.|..|:..|.|.:|||:|||...||
  Rat    66 HHPNIIRLFQVLITSSHVNFVLEYAPGGSLFELIKEGGPLQEEVAKKIFGQTVSAVKYCHNLDIV 130

  Fly   261 HRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLG 325
            |||:|.:|:|.|...|.|:.|||.:..|:||.||...||:..:.|||:...:.|.|.:.|:||||
  Rat   131 HRDIKPQNILTDAEGNGKLTDFGLATKFRPGTLLKELCGTKEFYAPELVLREPYNGKKTDVWSLG 195

  Fly   326 VVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHR 390
            |:||.:..|..||.|.|.:.:..::.:|.:.||.:.|.:.|:||.::|.:.|..|.:|:.|::|.
  Rat   196 VLLYFISTGYCPFRGVTTKDMEKKIATGTYTIPTYFSGQLENLIHQILTVSPEMRPSIEDIEKHP 260

  Fly   391 WM--CPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYL 453
            |:  |...:..:....|.:       ||        |...:|..::|...||:|..||...|.||
  Rat   261 WVRKCEVNIPTITCPDYKI-------VE--------MLCGMGYNANKILESLQKKKYDEPMAAYL 310

  Fly   454 LLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHK 518
            :|:|:|..:.|
  Rat   311 ILKDKVRQEIE------------------------------------------------------ 321

  Fly   519 RLSRHQTVLMSERNAHAGATPTVP-DPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASG 582
                           |...|..:| |.|            |||....:|.:           .||
  Rat   322 ---------------HGTTTSDMPVDQG------------PLPPQSPAHHS-----------VSG 348

  Fly   583 IPLPMRYTPLPTAASP--------APSNCSSTSSRVGRHSLSSSSPRSHRPVAI----------S 629
            :||..|      |:.|        .|      ..:|.||:::.|.  |..|:|:          :
  Rat   349 LPLKRR------ASEPNFGLLHIWPP------GEQVARHNVARSV--SMPPIALYGTKKQNSTST 399

  Fly   630 LSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQST 679
            .::.:.|..:...|..::|        :.:||.:||      :|.:|.|:
  Rat   400 SALHSRPVASPCVCNTILE--------IEIPLPTKQ------DFDMKTSS 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	95/251 (38%)
		UBA_SIK	418..458	CDD:270523	12/39 (31%)
Smokwl5	XP_038936416.1	STKc_AMPK-like	13..261	CDD:270905	95/250 (38%)
		UBA_MARK_Par1	275..314	CDD:270522	15/53 (28%)