Protein Alignment Sik2 and sik1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_031752275.1
• Gene: sik1 / 101733315
• XenbaseID: XB-GENE-6462410
• Length: 629
• Species: Xenopus tropicalis
• Alignment Length: 679
• Identity: 267/679 - (39%)
• Similarity: 366/679 - (53%)
• Gaps: 129/679 - (18%)

  Fly   120 GAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQK 184
            ||||...:       |:|||||||:.|:|||||||||||:||:|..:||||||||::||..||:|
 Frog     9 GAGGPPNR-------PLRVGFYDIKETLGKGNFAVVKLAQHRVTNTQVAIKIIDKTRLDPGNLEK 66

  Fly   185 VYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIIS 249
            :|||:||||:|||||||:||||||||:|||||:|||..||:|||:...||::|..||.||.||:|
 Frog    67 IYREIEIMKKLKHPHIIRLYQVMETKDMIYIVTEYAKNGELFDYLTARGRLTEQEARHKFLQILS 131

  Fly   250 AVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQY 314
            |||:||...:||||||||||||..||::|:|||||.|.:|.|:.|.||||||||||||||:|::|
 Frog   132 AVEFCHAHCVVHRDLKAENLLLTDNMDLKLADFGFGNFYKEGQALNTWCGSPPYAAPEVFQGQEY 196

  Fly   315 TGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTR 379
            .||.:|:||||||||||:||..|||...|.:||.|||.||||||:|||.:||.|||||||::|.:
 Frog   197 EGPPLDVWSLGVVLYVLLCGTFPFDAPNLPTLRQRVLEGRFRIPYFMSQDCESLIRRMLVVDPAK 261

  Fly   380 RYTIDQIKRHRWM--------CPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKT 436
            |.||.|||:|||:        .|:.|               :...|...:|.:| :.:||..::|
 Frog   262 RLTIGQIKQHRWVQTGDYLPPIPDAL---------------SPAPPCLQVLSLM-QSLGIDRERT 310

  Fly   437 RASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQ 501
            ..:|:.::|:|.||||.||.:|:     |...|||....|...|::...|.  ||.|....:
 Frog   311 LQALRNDSYNHYAAIYFLLVERL-----QEPRLGALTPPSPGPAAQNPPSC--DHVPPPGTA--- 365

  Fly   502 SKTISTSSILAKDQCHKRLS-RHQTVLMSERNAHAGATPTVPD---------------------- 543
            ...:......|...|...|| ..|::|..|....||::..||.
 Frog   366 GSPLVCGPQAAPTDCDCGLSFPLQSMLYLEEPPCAGSSAAVPPALPRAPPSCQEPKLHKEIPKVV 430

  Fly   544 PGP-GYY------------AKYGPLQ--LPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLP 593
            |.| |::            ...||.:  .|.||:..| .|..|...| .|..:|: ||:.:
 Frog   431 PSPAGFHRPESCRLPPWVPVPAGPYERCCPAPLSAQS-ATPVLQAQG-SVAQNGL-LPITF---- 488

  Fly   594 TAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMM----------- 647
                ......|.||...|..:|        |.:..|:.:....||:.:|.....
 Frog   489 ----QEGRRASDTSLTQGAVAL--------RQLRKSIRVRGLFSLSKIRAMNRQRGVRCTHTSHS 541

  Fly   648 --EAGGGPVGAVGVPLASKQLHQ-TIS----EFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESS 705
              ::|..|...:...|..::|.| |:|    :.:.:..::.|..||..|.:.|.|:  |.:|...
 Frog   542 PPQSGRDPKVFLQDVLQQQRLLQITVSPPSPKLLPQDPSDQCAPLLPYSYSAALGR--PLQAGGQ 604

  Fly   706 VGGVPPPASTTPTSSTAGPES---GSAPC 731
            :        .||.::..|.::   |:..|
 Frog   605 I--------LTPCNTDCGVQATPPGTHSC 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	173/251 (69%)
		UBA_SIK	418..458	CDD:270523	14/39 (36%)
sik1	XP_031752275.1	STKc_SIK	22..273	CDD:270973	172/250 (69%)
		UBA_SIK	295..334	CDD:270523	15/44 (34%)