Protein Alignment Sik2 and sik3

DIOPT Version :9

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_004916140.2
• Gene: sik3 / 100492939
• XenbaseID: XB-GENE-6042192
• Length: 1284
• Species: Xenopus tropicalis
• Alignment Length: 1388
• Identity: 422/1388 - (30%)
• Similarity: 598/1388 - (43%)
• Gaps: 356/1388 - (25%)

  Fly   135 PMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPH 199
            |.|:|:|:|:||||||||||||||.|.:|:.:||||||||::||:.||:|::|||:|||.|.|||
 Frog    20 PARIGYYEIDRTIGKGNFAVVKLATHIVTRAKVAIKIIDKTKLDEENLKKIFREVQIMKMLCHPH 84

  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDL 264
            ||:|||||||:.|||:|:||||.|||||::..:|||:|..||.||.||::||.:||.:.||||||
 Frog    85 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARKKFKQIVAAVHFCHCRNIVHRDL 149

  Fly   265 KAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLY 329
            ||||||||.|:|||||||||||.|.||:||.||||||||||||:||||:|.||::||||||||||
 Frog   150 KAENLLLDANLNIKIADFGFSNRFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 214

  Fly   330 VLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMC- 393
            |||||||||||||||:||.|||||:||||||||:|||||||.||||||::|.:::||.:|:|||
 Frog   215 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLEPSKRLSMEQICKHKWMCQ 279

  Fly   394 --PELLEHVLIAK-YNLGAERQTSVEP-SEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLL 454
              .:|....|||: .::..|||.  :| :|.:|..|.| :|:..::|..||:.:.|||.:|||.|
 Frog   280 GEQDLEFERLIAECQHVKLERQR--DPLNEQVLLTMVE-MGLDRERTLQSLRTDAYDHYSAIYSL 341

  Fly   455 LQDRVSHKKEQSNGLGASALASSTSASRMI-YSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHK 518
            |.||:...|       ...|.:..||.|.: ||:      ...|:...|.|:|
 Frog   342 LCDRLKRHK-------TLRLPTQPSAPRTVSYST------PSVQADAASNTVS------------ 381

  Fly   519 RLSRHQTVLMSERN--AHAGATPTV-----PDPGPGYYAKYGPLQLPLPLTGHSHLTG----YLN 572
             ::..|..|::..|  .....|.|:     .:|.|...|:|        |:...|..|    :..
 Frog   382 -INVPQVQLINPENQIVETNGTMTLDSDEAEEPSPEALARY--------LSMRRHTVGVPDTHNE 437

  Fly   573 GGGVEVDA--SGIPLPMRYTP-LPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDN 634
            .|..|:..  .|.|...:..| ||.           |.:....|:|....|.:|.... ..|:..
 Frog   438 SGTDELQKIFPGFPRVTQQIPFLPV-----------TQNTNVLHTLLPMPPSAHLEYK-EQSLLQ 490

  Fly   635 NPSLANLRCREMMEAGGGPVG-AVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVA----- 693
            .|:|..|.       |.||:| ......|:.|:|   ::.::|:.......:...:|..|
 Frog   491 PPTLQLLN-------GMGPLGRRASDGGANIQMH---AQLLLKRPRGPSPLVTMATTVTAVTPVD 545

  Fly   694 -EGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKA---N 754
             |..|..|..|:    |....:......|....|.:|..|.|:.    :.:....:|.::|   :
 Frog   546 EESSDGEPDQEA----VQRYLANRTKRHTLAMTSPTAEIPPELQ----RQLGQQQAFRNRAWPPH 602

  Fly   755 LGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRR-------------VH---VGSTNGSGGDSGQ 803
            |.......|..:::.|.       ||.|:.:..|             .|   :|:.|.|.....|
 Frog   603 LAPDLHRSMYKDSNTLH-------LPAERFSPVRRFSDGAATIQAFKAHLEKMGNQNSSIKQLQQ 660

  Fly   804 ETNDAKS----NGDSRS-----EKKVLAQG-------SSSTDEGCETDQGNDPGSASQESKGSNG 852
            |....:.    :.|.|:     ::.|:.|.       .....:.....|.:.|..:|..:
 Frog   661 ECEQLQKMYGVHMDERTLEHTQQQHVMYQHEHQHHLLQQQIQDCIRPAQPSPPLQSSSMT----- 720

  Fly   853 GGSGNANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNLSRGS 917
                     |.|.:...|       .:.|..::|...||...:            ..|.:|.|
 Frog   721 ---------PASENQPAL-------LTHQLQRLRIQPSSPPPN------------PASNHLFR-- 755

  Fly   918 SKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASASPAGISSEHSSERSLYGSHNSCIH 982
             :.|.|.|               ||   ||:||.|....|:|.......|||           |:
 Frog   756 -QPNSSPP---------------PS---SSAMLQTHGATSSSQYPGMPTHSS-----------IY 790

  Fly   983 MP---GALPLGLGLP-------QSSASTPTPNPTPPPNGGGVTFLDKRSPI-----HFREGRRAS 1032
            .|   |:.|..:.||       ||...:|............:....:..||     |.:..:|||
 Frog   791 QPSSTGSPPPSMALPRMSIQQQQSQQQSPQQVTIQVQEASDLPGASRGMPIIPCANHIQMQQRAS 855

  Fly  1033 DGLVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHS-----------HP 1086
                   |:||         .|:|.:....:          ||..:.|..||           :.
 Frog   856 -------LMSS---------MGNYSHRPLSK----------QLSADNAEVHSLNMAHFSPSTNYD 894

  Fly  1087 HAHQHPH---QHPHPHPQAYGLEELCQFPNGQFYALPGKHHPLLTLPHHHAHP-----AQHHHGH 1143
            ..|.|||   :.|.|.|..|........|:|...|    :...|.:|....:|     :|.::..
 Frog   895 QTHLHPHVFAEQPRPPPAVYTSTGSGYGPSGGTAA----YSQALKVPQMEQYPGFSTTSQQNYPS 955

  Fly  1144 HSLFHSGHQATPLLLEAAAGGDMYGHGCYAPPPPPPGLYT-HHQ----LGVGMAVPM------SP 1197
            .||    .||   ||.                 |.||.|| |||    :..|:..|.      :.
 Frog   956 SSL----QQA---LLS-----------------PTPGTYTRHHQQLPHMLQGLLSPRHSLTGHTD 996

  Fly  1198 MQKPP--LQQQLLQHRLLQQK-RQLFQKQYA------LEAQLAGRHHHHQQHSHHHHHHFGHSLG 1253
            ::.||  ..|.:.||:..||: .:||.:|.:      |..|.|...:||....|
 Frog   997 VRLPPADFMQLIKQHQQQQQELNELFNQQLSQGDPGNLPYQSASEPYHHLLQIH----------- 1050

  Fly  1254 PPPPPAPAPEHHLADELYELALLDRPRSGTPRLQ------HSMTMP---GAHAFSQMNLKTSYIS 1309
              |..|..|:......:.....::...||..:.:      .|:..|   ..|..::..|.|..:.
 Frog  1051 --PASAATPDSRYHPIMLHSESMEEDFSGEGQKESEGETVRSLCKPCQETRHGDTESLLGTLALK 1113

  Fly  1310 QSDQVPGAAPNGAGSGGSAAGVSCSAPPSTAPGTPTVKCKPTTPHGHSLDSDYHTSTPVLSLFTP 1374
            :.:.       |.....:....:.:...|..|| ||..|.......|.:|...|...|    :.|
 Frog  1114 EQEL-------GVQQYKTQTSYNRTKSASREPG-PTANCMDRASPPHVMDVPDHNGIP----YPP 1166

  Fly  1375 NWQSLVKPLSESPILEISEHLES 1397
                  :|.|       |||..|
 Frog  1167 ------RPSS-------SEHARS 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	184/251 (73%)
		S_TKc	141..392	CDD:214567	184/250 (74%)
sik3	XP_004916140.2	STKc_SIK	25..277	CDD:270973	184/251 (73%)
		UBA_SIK3	306..350	CDD:270593	18/44 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910