Protein Alignment Sik2 and mark4

DIOPT Version :9

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_012824414.1
• Gene: mark4 / 100491038
• XenbaseID: XB-GENE-6042140
• Length: 681
• Species: Xenopus tropicalis
• Alignment Length: 688
• Identity: 266/688 - (38%)
• Similarity: 359/688 - (52%)
• Gaps: 146/688 - (21%)

  Fly   133 KEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKH 197
            :|| .||.|.:.|||||||||.||||||.:|..|||||||||:||:.::|||::|||.|||.|.|
 Frog    44 EEP-HVGNYRLLRTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 107

  Fly   198 PHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHR 262
            |:|:||::|:||:..:|::.||||.||:|||:..:|||.|..||.||.||:|||.|||:|.||||
 Frog   108 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 172

  Fly   263 DLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVV 327
            ||||||||||...|||||||||||.|.||..|.|:||||||||||:|:||:|.|||:|:|||||:
 Frog   173 DLKAENLLLDSESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSLGVI 237

  Fly   328 LYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM 392
            ||.||.|:|||||..|:.||:|||.|::||||:||::||.::||.|||.|::|.|:|||...:||
 Frog   238 LYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEGVLRRFLVLNPSKRCTLDQIMNDKWM 302

  Fly   393 CPELLEHVLIAKYNLGAER---QTSVEPSED-----ILRIMAEYVGIGSDKTRASLKKNTYDHVA 449
                         |:|.:.   :...||.||     .:.||.| :|...::.:.:|..|.|:.|.
 Frog   303 -------------NIGFDSDDLKPYKEPEEDNADPKRIEIMLE-MGYSREEIKDALSSNKYNEVM 353

  Fly   450 AIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKD 514
            |.||||     .:|.:|.| |.|...|:.|.||           ::..|...:....:||:.:|:
 Frog   354 ATYLLL-----GRKPESEG-GESRSDSTLSLSR-----------SRVASDVTNGATKSSSVHSKN 401

  Fly   515 Q-CHKRLSRHQTVLMSERNAHAGATPTVPD-----PGPGYYAKYGPLQLP--------------- 558
            | .::|..||        :...|..|....     ||.|.....|....|
 Frog   402 QRGYQRQRRH--------SDFCGPAPAPSQAKRSPPGVGDDGAVGERLAPRRGSGSVGGGSRPPP 458

  Fly   559 --LPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRV-------GRHS 614
              .|:..|:|     |....|     ||.|.:..| ||..:..|......::.|       .|||
 Frog   459 PSSPMVSHAH-----NPNKAE-----IPEPRKEAP-PTTINTPPGVMGRRNTYVCTDRHSSERHS 512

  Fly   615 L------SSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAG--------GGPV----GAVGVPL 661
            |      :||:|  .||.|:|      ||..::..|..:..|        ||.|    |....|.
 Frog   513 LLHNDKENSSTP--SRPPALS------PSTQSIAERSSLSRGSNVRSTFHGGHVRDRRGQNPPPS 569

  Fly   662 ASKQLHQTI--------SEFIIKQSTEDCRALLQQSTAV----AEGKDDP---PKAESSVGGVP- 710
            :....|:.:        |....|.:::..|.:..:|..|    ..|...|   ..|.||:...|
 Frog   570 SPTHPHEGLNQSRTRATSNLFSKLTSKLTRRVTDESERVWRPEVTGSYIPWNKTSANSSLLRPPR 634

  Fly   711 --------PPASTTPTSSTAGPESGS-----APCPGEI 735
                    ||..  ||.::..|.|.|     :|.||::
 Frog   635 DVRRSSQHPPLQ--PTETSIAPNSPSSIGRPSPLPGKL 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	162/251 (65%)
		S_TKc	141..392	CDD:214567	162/250 (65%)
mark4	XP_012824414.1	STKc_MARK	50..302	CDD:270974	162/251 (65%)
		UBA_MARK_Par1	323..361	CDD:270522	13/43 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910