Protein Alignment Sik2 and brsk2b

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_009301700.1
• Gene: brsk2b / 100149571
• ZFINID: ZDB-GENE-100422-3
• Length: 886
• Species: Danio rerio
• Alignment Length: 925
• Identity: 248/925 - (26%)
• Similarity: 375/925 - (40%)
• Gaps: 249/925 - (26%)

  Fly   125 SGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREV 189
            ||||....:....||.|.:|:|:|||...:|||..|.:|..:|||||:::.:|.::.|.||.||:
Zfish     4 SGKDNSSQQHANYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREI 68

  Fly   190 EIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYC 254
            .|:|.::|||::||:.|.|.|..:|:|.|:.|.||:|||:.|.||::...||..|.|||||:::|
Zfish    69 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 133

  Fly   255 HKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEI 319
            |...|.|||||.||||||...||:|||||.::......||.|.||||.||.|||..|::|.|.:.
Zfish   134 HSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 198

  Fly   320 DIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTID 384
            |:||.||:|:.|:.||||||...|::|.::|..|.|.:|.|:..:|::|:|.|:.::.|:|.|::
Zfish   199 DVWSCGVILFALLVGALPFDDDNLRNLLEKVKLGVFHMPHFIPPDCQNLLRGMIEVDATKRLTLE 263

  Fly   385 QIKRHRWMC-----PELLEHVLIAKYNLGAERQTSVE--PS-----EDILRIMAEYVGIGSDKTR 437
            ||::|.|..     ||..:.|         .|:.::.  ||     .|:|..| ..:|...||.:
Zfish   264 QIQKHTWYIGGKNEPEPEQPV---------PRKVAIRTLPSTEDIDPDVLESM-HSLGCFRDKNK 318

  Fly   438 --ASLKKNTYDHVAAIYLLLQDR------------------------------VSHKKEQSNGLG 470
              ..|..:..:....||.||.||                              ..|.|.:.....
Zfish   319 LMKDLLSDDDNQEKMIYFLLLDRKERYPSHEDQNLPPRNEIDPPRKRVDSPLLTRHNKRRPERKS 383

  Fly   471 ASALA----------------SSTSASRMIYSSR---NDHQPTQQQSQQQSKTISTSSILAKDQC 516
            ...|:                :....|:.::|..   :|..|..|..:::|::||.:|
Zfish   384 MEVLSVTEGGSPVPVRRAIDMAQHGQSKSVFSKSLDISDANPILQSKEERSRSISGAS------- 441

  Fly   517 HKRLSRHQTVLMSERNAHAGATPTVPDPGP-GYYAKYGPLQLPLPLTGHSHLTGYLNGGG----- 575
             ..||  .:.|.|.|.....|.|  |.... .|...:.|...|:         ..|||.|
Zfish   442 -SGLS--TSPLSSPRPMRRFAVP--PQSSDLTYSPNHSPTHAPV---------ARLNGTGPHSPK 492

  Fly   576 ----------------------------VEVDASGIPLPMRYTPLPTAASPAPSN-CSSTSSRVG 611
                                        ::...|. ||| ..||:|..|...||. |.....::
Zfish   493 IFLPKTAADQLNNKTQTLPAKPKVADKPLQATRSN-PLP-NSTPVPPVAKSEPSTPCQPLPPQI- 554

  Fly   612 RHSLSSSSPRSHRP---VAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEF 673
                 ..||:..||   |...||:..:| |:.:|...:....|.......:|......|
Zfish   555 -----PGSPKIRRPPLTVPPKLSVPLSP-LSPIRLHHLHPLAGTDHNGKSIPTIQVTPH------ 607

  Fly   674 IIKQSTEDCRALLQQSTAVAEGKDDP-------PKAESSVGGVPPPASTTPTSSTAGPESGS--- 728
               .|.........:.|.|...|:.|       |....|:||:|   ..|..:|......||
Zfish   608 ---PSPRGSPLPTPKGTPVHTPKESPAGTPSPTPPPSPSIGGMP---WRTRLNSIKNSFLGSPRF 666

  Fly   729 ------APCPGEINGKTIKT---MSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPL----- 779
                  .|...|::..|.::   ::..|.|.:..||         .:..::|..:::.||
Zfish   667 HRRKLQVPTQEEMSSLTPESSPELAKKSWFGNFINL---------EKEEQIFVVIRDKPLSSIKA 722

  Fly   780 --------------PVEQRTKRRVHVGSTNG----------------SGGDSGQETNDAKS---- 810
                          .|..:|..|....||.|                :...:..:.|...|
Zfish   723 DIVHAFLSIPSLSHSVVSQTSFRAEYKSTAGPTVFQKPVKFQVDITYTESMAATKENGIYSVTFT 787

  Fly   811 --NGDSRSEKKVL----AQGSSSTDEGCETDQGNDPGSASQESKGSNGGGSGNANGGPTSHSSSD 869
              :|.||..|:|:    ||..|:.|:         ||  .|:..||           |.|:....
Zfish   788 LLSGPSRRFKRVVETIQAQLLSTHDQ---------PG--VQQLSGS-----------PLSNFFDV 830

  Fly   870 LTRLVGTTTSGQ-SH 883
            :.:|.....:|| ||
Zfish   831 IKQLFSDEKNGQVSH 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	118/251 (47%)
		UBA_SIK	418..458	CDD:270523	12/46 (26%)
brsk2b	XP_009301700.1	STKc_BRSK1_2	18..271	CDD:270983	119/252 (47%)
		UBA_BRSK	298..351	CDD:270525	13/53 (25%)
		PHA03247	<342..630	CDD:223021	55/326 (17%)