Protein Alignment Sik2 and sik2

DIOPT Version :9

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_002932962.2
• Gene: sik2 / 100125196
• XenbaseID: XB-GENE-950070
• Length: 899
• Species: Xenopus tropicalis
• Alignment Length: 1275
• Identity: 402/1275 - (31%)
• Similarity: 518/1275 - (40%)
• Gaps: 443/1275 - (34%)

  Fly   135 PMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPH 199
            |:||||||||||:|||||||||||||||||.|||||||||||||..||:|:||||:|||.|.|||
 Frog    14 PVRVGFYDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKSQLDSVNLEKIYREVQIMKMLDHPH 78

  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDL 264
            |||||||||||||:|:|:|||..||||||:|.:||::|..||.|||||:|||||||.:.||||||
 Frog    79 IIKLYQVMETKNMLYLVTEYAKNGEIFDYLANHGRLNEPEARRKFWQILSAVEYCHGRNIVHRDL 143

  Fly   265 KAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLY 329
            ||||||||.:||||||||||.|.:|.||.||||||||||||||||||:||.||::||||:|||||
 Frog   144 KAENLLLDNHMNIKIADFGFGNFYKNGEPLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLY 208

  Fly   330 VLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCP 394
            |||||||||||.||..||.|||.||||||:|||.||||||||||||||::|.:|.|||.|:||..
 Frog   209 VLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEECEHLIRRMLVLEPSKRLSIAQIKEHKWMMA 273

  Fly   395 ELLEH--VLIAKYNLGAERQTSV-EPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQ 456
            |:..|  ||   |:...::..|: |.:|.:||:| ..:||...||..||:..:|:|.||||.||.
 Frog   274 EVPVHRPVL---YSQTQDKAASIGEYNEQVLRLM-HSLGIDQQKTIESLQNRSYNHFAAIYYLLV 334

  Fly   457 DRV-SHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRL 520
            :|: ||:                  |.....||.|.:      |::..|::
 Frog   335 ERLKSHR------------------SSFPVESRIDAR------QRRPSTVA-------------- 361

  Fly   521 SRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPL 585
              .|||        ..|:..||           |:.|                         :|.
 Frog   362 --EQTV--------TKASTIVP-----------PVNL-------------------------LPQ 380

  Fly   586 PMRY--TPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMME 648
            .||.  .|:...||||.:
 Frog   381 NMRLLRAPILPEASPAET----------------------------------------------- 398

  Fly   649 AGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPA 713
                    ...|..|.|...|..|                    .|..:.||.....:..:||
 Frog   399 --------FSYPQISSQAESTFLE--------------------EESVNTPPVNGCLLDPLPP-- 433

  Fly   714 STTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESP 778
                  .|......|.||                                     .:.:|
 Frog   434 ------VTIRKGCQSLPC-------------------------------------NMMET----- 450

  Fly   779 LPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCET--DQGNDPG 841
                                                            |.|||.||  |...||.
 Frog   451 ------------------------------------------------SIDEGIETEDDTEEDPA 467

  Fly   842 SASQESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYS 906
            .|....:|        ...|...|:.|::|..:....||          .....|.|.
 Frog   468 QAFAACQG--------RRSGQRRHTLSEVTNQMVMLPSG----------GPDMEGKLF------- 507

  Fly   907 KSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASASPAGISSEHSSER 971
             ::..|.|.||..|.    ||                |||                |.|:.|.:.
 Frog   508 -TIGNNPSLGSVDSE----YD----------------MGS----------------IQSDLSFQD 535

  Fly   972 SLYGSHNSCI----HMPGALPLGLGLPQSSASTPT-PNPTPPPNGGGVTFLDKRSPIHFREGRRA 1031
            .  |:.|..:    .:....|..:||..::.:.|| |:.....:        .|||:.|||||||
 Frog   536 D--GTMNEVVMANQSVTRLTPPFIGLRPTNLAMPTLPSQKREAH--------NRSPVSFREGRRA 590

  Fly  1032 SDGLVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHSHPHAHQH----- 1091
            ||..:.||:::          :..:....|:..|.||:.::|...::..     |...|:
 Frog   591 SDTSLTQGIVA----------FRQHLQNLARTKGILELNKIQMFYEQMG-----PDEEQNVTSVP 640

  Fly  1092 ----PHQHPHPHPQAYGLEELCQFPNGQFYALPGKHHPLLTLPHHHAHPAQHHHGHHSLFHSGHQ 1152
                .|.| ||...:..|..:..||||        .||.| |....:...|:.  .|.|     |
 Frog   641 NQLQDHNH-HPLDMSAQLSNVSTFPNG--------IHPHL-LSRRQSLETQYL--QHRL-----Q 688

  Fly  1153 ATPLLLEAAAGGDMYGHGCYAPPPPPPGLYTHHQLGVGMAVPMSPMQKPPLQQQLLQHRLLQQKR 1217
            ...||.:|.....:|   |...|                         ..|:|||.:|| |.|||
 Frog   689 KANLLAKAQNSCQLY---CKETP-------------------------RSLEQQLQEHR-LHQKR 724

  Fly  1218 QLFQKQYALEA-----QLAGRHHHHQQHSHHHHH-------HFGHSLGPPPPPAPAPEHHLADEL 1270
            ...|||..|:|     |:|...:..|.......|       .||  |..|..|...|   .:||:
 Frog   725 LFLQKQPQLQAYFKQMQIAETSYPMQTQQLPLSHQETVQPAQFG--LSQPLSPVMEP---ASDEM 784

  Fly  1271 -YELALLDRPRSGTPRLQHSMTMPGAHAFSQMNLKTSYISQSDQVPGAAPNGAGSGGSAAGVSCS 1334
             |:..|....:..:.::| ::..|.............|..|:.::.| .|:......:....|.:
 Frog   785 QYDPFLSQYHKLHSQQMQ-NLVQPSQPQIPVQQPPLQYAYQTCEISG-VPSHEPEYTNQCQYSMN 847

  Fly  1335 APPSTAPGTPTVKCKPTTPHGHSLDSDYHTSTPVLSLFTP 1374
               ||..|..|:....:...||...|.|.|    |:|..|
 Frog   848 ---STQQGVMTLPENQSHLAGHDPQSSYET----LALSEP 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	199/251 (79%)
		S_TKc	141..392	CDD:214567	198/250 (79%)
sik2	XP_002932962.2	STKc_SIK	19..271	CDD:270973	199/251 (79%)
		UBA_SIK2	297..341	CDD:270592	20/44 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	422	1.000	Domainoid score	I626
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1293
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		oto104491
Panther	1	1.100	-	-	O	PTHR24343
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2250
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150