Protein Alignment moody and GPR50

DIOPT Version :10

• Sequence 1: NP_569970.2
• Gene: moody / 31168
• FlyBaseID: FBgn0025631
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_004215.2
• Gene: GPR50 / 9248
• HGNCID: 4506
• Length: 617
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 149/682 - (21%)
• Similarity: 250/682 - (36%)
• Gaps: 158/682 - (23%)

  Fly    24 PPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAAAFIISLCIADLLFCAL 88
            |||        |:.|......:.::|.:.||.:.::|:.|..|:||....|::||.:||:|....
Human    24 PPA--------LIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIY 80

  Fly    89 VLPFQGLRFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYVMITHHGLYARIYKRHWI 153
            ..|........|.|...|:.|:::.||...::..|:..|..|.||||..|.|...|.||:.....
Human    81 PYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNT 145

  Fly   154 AVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSKTTLFITAFVIPCLVIIAC 218
            .:.:...|:.:....||.:.  .|...||.|..|| |....:......|:....||:|.|::..|
Human   146 CIYLVITWIMTVLAVLPNMY--IGTIEYDPRTYTC-IFNYLNNPVFTVTIVCIHFVLPLLIVGFC 207

  Fly   219 YAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDVP 283
            |.:| |.                      :.||:..    |:|.  .|.|:::
Human   208 YVRI-WT----------------------KVLAARD----PAGQ--NPDNQLA------------ 231

  Fly   284 ETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSFVVCYLPITI----VKVADKNV--EHP 342
                                    |.|....:..|||.|.||:.||.:    |.|:.|.:  :.|
Human   232 ------------------------EVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIP 272

  Fly   343 S-LHICSYILLYLSACINPIIYVIMNKQYRKAYKTVVFCQPARLLLPFGKTNGASSAAEKWKDTG 406
            : |::.:|.:.|.::|:|.:||.::|:.:|:.|.|:.......::...|..:......|
Human   273 NWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQE------ 331

  Fly   407 LSNNHSRTIVSQMSGGTGAASGAGTATGTAAVAVMQTPPEVQQAQALEMVSRG-PDLISKSNLPQ 470
                 :||:....:.....|.....|  .|..||.:||..|:........:.| ||  ..|..|:
Human   332 -----ARTLARARAHARDQAREQDRA--HACPAVEETPMNVRNVPLPGDAAAGHPD--RASGHPK 387

  Fly   471 PNVTPPPPSVLTATPNGSNSNSLTLRLPLKKNNHCYTNSGFNSSTPSPSSGLGIGIS----SSSI 531
            |:               |.|:|...:.....:...:::|...|....|.||.....|    |:::
Human   388 PH---------------SRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATV 437

  Fly   532 YRPGVGSLGSGSASIRRITMVGDDIILEEEELPPTPPATSAP--------------------TTP 576
            | |...|:...:.|:.   ..||.:..:.:.: ...||:|.|                    .|.
Human   438 Y-PKPASVHFKADSVH---FKGDSVHFKPDSV-HFKPASSNPKPITGHHVSAGSHSKSAFSAATS 497

  Fly   577 APPPPSSPLHPLSTDSSTTTISGGAVVAGSSAPKPAT---PTPHIYMNVDSPKRNQYYMDRNTNA 638
            .|.|.:..:.|.::.:..||         :..|||||   |.|   ...|:|:.:..:.......
Human   498 HPKPTTGHIKPATSHAEPTT---------ADYPKPATTSHPKP---TAADNPELSASHCPEIPAI 550

  Fly   639 VAPESDSGPANTSATVSISGSKLTAKMKFPKD 670
            ..|.||......||:...:|....|..:...|
Human   551 AHPVSDDSDLPESASSPAAGPTKPAASQLESD 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_569970.2	7tmA_GPR84-like	37..374	CDD:320338	82/343 (24%)
		TM helix 1	38..64	CDD:320338	5/25 (20%)
		TM helix 2	71..94	CDD:320338	7/22 (32%)
		TM helix 3	109..139	CDD:320338	10/29 (34%)
		TM helix 4	153..171	CDD:320338	2/17 (12%)
		TM helix 5	196..305	CDD:320338	15/108 (14%)
		TM helix 6	306..336	CDD:320338	12/33 (36%)
		TM helix 7	342..367	CDD:320338	8/25 (32%)
GPR50	NP_004215.2	7tmA_Mel1	29..305	CDD:320337	82/343 (24%)
		TM helix 1	30..56	CDD:320337	5/25 (20%)
		TM helix 2	63..88	CDD:320337	7/24 (29%)
		TM helix 3	101..131	CDD:320337	10/29 (34%)
		TM helix 4	143..165	CDD:320337	3/21 (14%)
		TM helix 5	185..214	CDD:320337	9/51 (18%)
		TM helix 6	230..260	CDD:320337	10/65 (15%)
		TM helix 7	273..298	CDD:320337	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..438		24/116 (21%)
		DUF4045	<379..>588	CDD:433066	48/238 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..596		27/132 (20%)