DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment moody and BDKRB1

DIOPT Version :9

Sequence 1:	NP_001188534.1	Gene:	moody / 31168	FlyBaseID:	FBgn0025631	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_000701.2	Gene:	BDKRB1 / 623	HGNCID:	1029	Length:	353	Species:	Homo sapiens

Alignment Length:	402	Identity:	82/402 - (20%)
Similarity:	152/402 - (37%)	Gaps:	92/402 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LEDGYPPLEALT---TMVPPADATGFSQSL----LTFAAVMTFLIMI--VGICGNLLTVVALLKC 64
            :...:||||..:   :.:.|.:||....:.    |....:.||:|.|  .|:.|||..::..|..
Human     1 MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLP 65

  Fly    65 PKVRNVAAAFIISLCIADLLFCALVLPFQGLR-FVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIA 128
            .:..|||..::.:|..:||:| .|.|||.... :.|..|..|.:|||:|..:...|:.:|:..:.
Human    66 RRQLNVAEIYLANLAASDLVF-VLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVV 129

  Fly   129 MITINRYVMITHHGLYARIYKRHWIAVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTD 193
            .|:.:||.::.|.....|..:|....|.....|:....:.:||.|....:...|..:..|.::..
Human   130 AISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLP 194

  Fly   194 DHG-HSSK-TTLFITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSG 256
            ... |.:: ..|.|..|::|...|      :|:..|               |..:||
Human   195 HEAWHFARIVELNILGFLLPLAAI------VFFNYH---------------ILASLR-------- 230

  Fly   257 ALPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLS 321
                                                 ||.:..|.....|.:.:.|.::|.:.::
Human   231 -------------------------------------TREEVSRTRCGGRKDSKTTALILTLVVA 258

  Fly   322 FVVCYLPITIVKVADKNVEHPSLHICSY------------ILLYLSACINPIIYVIMNKQYR-KA 373
            |:||:.|.......:...:..::..|.:            ...:.::.:||:|||.:.:.:| |.
Human   259 FLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKV 323

  Fly   374 YKTVVFCQPARL 385
            ::....|.|..|
Human   324 WELYKQCTPKSL 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_001188534.1	7tm_4	44..>167	CDD:304433	36/125 (29%)
		7tm_1	53..363	CDD:278431	61/324 (19%)
		7tm_4	<310..380	CDD:304433	14/82 (17%)
BDKRB1	NP_000701.2	7tmA_BK-1	38..323	CDD:320502	70/351 (20%)
		TM helix 1	40..64	CDD:320502	8/23 (35%)
		TM helix 2	73..94	CDD:320502	8/21 (38%)
		TM helix 3	111..133	CDD:320502	5/21 (24%)
		TM helix 4	156..172	CDD:320502	2/15 (13%)
		TM helix 5	200..223	CDD:320502	6/28 (21%)
		TM helix 6	249..271	CDD:320502	6/21 (29%)
		TM helix 7	291..316	CDD:320502	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100