Protein Alignment moody and GPR88

DIOPT Version :10

• Sequence 1: NP_569970.2
• Gene: moody / 31168
• FlyBaseID: FBgn0025631
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_071332.2
• Gene: GPR88 / 54112
• HGNCID: 4539
• Length: 384
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 96/435 - (22%)
• Similarity: 167/435 - (38%)
• Gaps: 130/435 - (29%)

  Fly    46 IMIVGICGNLLTVVALLKCPKVRNVAAAFIISLCIADLLFCALVLPFQGLRFVQGT--------W 102
            :.|.|...|.:.:..:....|::..:.|||::.|.|||..|||.:|.:.:..:..|        |
Human    41 LAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADW 105

  Fly   103 RHGQVLCRLIPFIQYGNIG----VSLLCIAMITINRYVMITH-HGLYARIYKRHWIAVMIAACWL 162
            .......||   ::.|.:|    ||||...::.:|||::||. ...|..:|:|...|.|:|..|.
Human   106 DGAGGSYRL---LRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWA 167

  Fly   163 FSYGMQLPTLLGEWG--------RFGYDSRLQTCSIMTDDHGHSSKTTLFITAFVIPCLVIIACY 219
            .:.|:.|  ||..|.        |..|.:.|...:::       ::|.|           ::.||
Human   168 LALGLVL--LLPPWAPRPGAAPPRVHYPALLAAAALL-------AQTAL-----------LLHCY 212

  Fly   220 AKIFWVVHKSEQRLKRHATKQNSIPN----NLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSI 280
            ..|.        |..|.:.|:.|:.|    :..|..:..:.|.| ||:..|
Human   213 LGIV--------RRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFP-GAQHAP-------------- 254

  Fly   281 DVPETAPSGKQQPTRVKD-QREVRAKRNEWRITKM-VLAIFLSFVVCYLPITIVKVADK-NVEHP 342
                 .|.|...|.:.:. ...:..:|.:.|::.: ||.:...|::...|:..|.:|.. ::..|
Human   255 -----GPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVP 314

  Fly   343 -SLHICSYILLYLSACINPIIYVIMNKQYRKAYKTVVFCQPARLLLPFGKTNGASSAAEKWKDTG 406
             .:...|::|....:.:||::|...|:::|::.::|         ||
Human   315 WGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSV---------LP------------------ 352

  Fly   407 LSNNHSRTIVSQMSGGTGAASGAGTATGTAAVAVMQTPPEVQQAQ 451
                           |.|.|:    |...||.||    |.|.|||
Human   353 ---------------GVGDAA----AAAVAATAV----PAVSQAQ 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_569970.2	7tmA_GPR84-like	37..374	CDD:320338	80/356 (22%)
		TM helix 1	38..64	CDD:320338	3/17 (18%)
		TM helix 2	71..94	CDD:320338	11/22 (50%)
		TM helix 3	109..139	CDD:320338	11/33 (33%)
		TM helix 4	153..171	CDD:320338	6/17 (35%)
		TM helix 5	196..305	CDD:320338	19/113 (17%)
		TM helix 6	306..336	CDD:320338	7/30 (23%)
		TM helix 7	342..367	CDD:320338	6/25 (24%)
GPR88	NP_071332.2	7tmA_GPR88-like	33..347	CDD:320339	80/356 (22%)
		TM helix 1	33..59	CDD:320339	3/17 (18%)
		TM helix 2	66..91	CDD:320339	11/24 (46%)
		TM helix 3	112..143	CDD:320339	11/33 (33%)
		TM helix 4	156..178	CDD:320339	8/23 (35%)
		TM helix 5	189..218	CDD:320339	8/54 (15%)
		TM helix 6	277..307	CDD:320339	6/29 (21%)
		TM helix 7	315..340	CDD:320339	5/24 (21%)