Protein Alignment moody and MTNR1B

DIOPT Version :10

• Sequence 1: NP_569970.2
• Gene: moody / 31168
• FlyBaseID: FBgn0025631
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_005950.1
• Gene: MTNR1B / 4544
• HGNCID: 7464
• Length: 362
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 84/363 - (23%)
• Similarity: 149/363 - (41%)
• Gaps: 83/363 - (22%)

  Fly    24 PPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAAAFIISLCIADLLFCAL 88
            ||..|...|..|:...|        |.:.||||.::::|:..|:||....|::||.:|||:....
Human    36 PPWVAPALSAVLIVTTA--------VDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFY 92

  Fly    89 VLPFQGLRFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYVMITHHGLYARIYKRHWI 153
            ..|...:......|..|:..|:...|:...::..|:..|..|.||||..|.|...|.|||:|...
Human    93 PYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHT 157

  Fly   154 AVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCS-IMTDDHGHSSKTTLFITAFVIPCLVIIA 217
            .:.|...||.:....||...  .|...||.|:.:|: |.|....:::  .:.:..|::|..|:..
Human   158 PLHICLIWLLTVVALLPNFF--VGSLEYDPRIYSCTFIQTASTQYTA--AVVVIHFLLPIAVVSF 218

  Fly   218 CYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDV 282
            ||.:| ||:                              .|.:..:.:|.:|:.
Human   219 CYLRI-WVL------------------------------VLQARRKAKPESRLC----------- 241

  Fly   283 PETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSFVVCYLPITIVKVA------DKNVEH 341
                                 .|.::.|....:..:|:.|.:|:.|:..:.:|      :...:.
Human   242 ---------------------LKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQI 285

  Fly   342 P-SLHICSYILLYLSACINPIIYVIMNKQYRKAYKTVV 378
            | .|.:.||:|.|.::|:|.|:|.::|:.:|:.||.::
Human   286 PEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRIL 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_569970.2	7tmA_GPR84-like	37..374	CDD:320338	77/344 (22%)
		TM helix 1	38..64	CDD:320338	7/25 (28%)
		TM helix 2	71..94	CDD:320338	7/22 (32%)
		TM helix 3	109..139	CDD:320338	9/29 (31%)
		TM helix 4	153..171	CDD:320338	4/17 (24%)
		TM helix 5	196..305	CDD:320338	11/108 (10%)
		TM helix 6	306..336	CDD:320338	6/35 (17%)
		TM helix 7	342..367	CDD:320338	10/25 (40%)
MTNR1B	NP_005950.1	7tmA_Mel1B	41..319	CDD:320522	79/352 (22%)
		TM helix 1	42..68	CDD:320522	9/33 (27%)
		TM helix 2	75..100	CDD:320522	7/24 (29%)
		TM helix 3	113..143	CDD:320522	9/29 (31%)
		TM helix 4	155..177	CDD:320522	5/21 (24%)
		TM helix 5	197..226	CDD:320522	7/31 (23%)
		TM helix 6	244..274	CDD:320522	5/29 (17%)
		TM helix 7	287..312	CDD:320522	9/24 (38%)