DRSC/TRiP Functional Genomics Resources

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Protein Alignment moody and MTNR1A

DIOPT Version :9

Sequence 1:NP_001188534.1 Gene:moody / 31168 FlyBaseID:FBgn0025631 Length:670 Species:Drosophila melanogaster
Sequence 2:NP_005949.1 Gene:MTNR1A / 4543 HGNCID:7463 Length:350 Species:Homo sapiens


Alignment Length:387 Identity:92/387 - (23%)
Similarity:161/387 - (41%) Gaps:87/387 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 AAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAAAFIISLCIADLLFCALVLPFQGLRFVQGTWR 103
            |.|:.|.| :|.|.||||.::::.:..|:||....|::||.:|||:......|...:......|.
Human    31 ACVLIFTI-VVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWN 94

  Fly   104 HGQVLCRLIPFIQYGNIGVSLLCIAMITINRYVMITHHGLYARIYKRHWIAVMIAACWLFSYGMQ 168
            .|.:.|::..|:...::..|:..|..|.||||..|.|...|.::|........:...||.:....
Human    95 LGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAV 159

  Fly   169 LPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSKTTLFITA--FVIPCLVIIACYAKIFWVVHKSEQ 231
            ||.|..  |...||.|:.:|   |.....||..|:.:..  |::|.:::|.||.:|:.:|.:..|
Human   160 LPNLRA--GTLQYDPRIYSC---TFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQ 219

  Fly   232 RLKRHATKQNSIPNNLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRV 296
                                                                           ||
Human   220 ---------------------------------------------------------------RV 221

  Fly   297 KDQREVRAKRNEWRITKMVLAIFLSFVVCYLPITIVKVA---DKNVEHPS----LHICSYILLYL 354
            |..|:.:.|..::|....:..:|:.|.:|:.|:..:.:|   |.....|.    |.:.||.:.|.
Human   222 KPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYF 286

  Fly   355 SACINPIIYVIMNKQYRKAYKTVV--FCQPARLLLPFGKTNGASSAAE--KWKDTGLSNNHS 412
            ::|:|.|||.::|:.:||.|:.::  .| .||:..    .:.::..|:  |||.:.|..|::
Human   287 NSCLNAIIYGLLNQNFRKEYRRIIVSLC-TARVFF----VDSSNDVADRVKWKPSPLMTNNN 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
moodyNP_001188534.1 7tm_4 44..>167 CDD:304433 35/122 (29%)
7tm_1 53..363 CDD:278431 71/318 (22%)
7tm_4 <310..380 CDD:304433 21/78 (27%)
MTNR1ANP_005949.1 7tm_GPCRs 28..306 CDD:333717 82/343 (24%)
TM helix 1 30..54 CDD:320095 10/23 (43%)
TM helix 2 63..85 CDD:320095 7/21 (33%)
TM helix 3 101..123 CDD:320095 4/21 (19%)
TM helix 4 146..162 CDD:320095 3/15 (20%)
TM helix 5 185..208 CDD:320095 6/22 (27%)
TM helix 6 234..259 CDD:320095 5/24 (21%)
TM helix 7 274..299 CDD:320095 9/24 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 126 1.000 Domainoid score I5405
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 148 1.000 Inparanoid score I4405
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42108
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24228
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.060

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