DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment moody and Agtr1a

DIOPT Version :9

Sequence 1:	NP_001188534.1	Gene:	moody / 31168	FlyBaseID:	FBgn0025631	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_112247.2	Gene:	Agtr1a / 24180	RGDID:	2070	Length:	359	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	88/412 - (21%)
Similarity:	158/412 - (38%)	Gaps:	108/412 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLEDGYPPLEALTTMVPPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAA 72
            |.|||   ::.:....|.|   |....:......:..:|.:|||.||.|.|:.:....|::.||:
  Rat     6 SAEDG---IKRIQDDCPKA---GRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVAS 64

  Fly    73 AFIISLCIADLLFCALVLPFQGL-RFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYV 136
            .|:::|.:|||.| .|.||...: ..::..|..|..||::.......|:..|:..:..::|:||:
  Rat    65 VFLLNLALADLCF-LLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYL 128

  Fly   137 MITHHGLYARIYKRHWIA-VMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSK 200
            .|. |.:.:|:.:...:| |.....||.:....||.::.....|..::.:..|:.    |..|..
  Rat   129 AIV-HPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAF----HYESRN 188

  Fly   201 TTL--------FITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGA 257
            :||        .|..|:.|.|:|:..|. :.|                               .|
  Rat   189 STLPIGLGLTKNILGFLFPFLIILTSYT-LIW-------------------------------KA 221

  Fly   258 LPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSF 322
            |....|.|                        |.:|            ||: .|.::::||.|.|
  Rat   222 LKKAYEIQ------------------------KNKP------------RND-DIFRIIMAIVLFF 249

  Fly   323 VVCYLPITIVKVADKNVEHPSLHIC------------SYILLYLSACINPIIYVIMNKQYRKAYK 375
            ...::|..|....|..::...:|.|            :..:.|.:.|:||:.|..:.|:::|
  Rat   250 FFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKK--- 311

  Fly   376 TVVFCQPARLLLPFGKTNGASS 397
              .|.|..:.:.|..|::.:.|
  Rat   312 --YFLQLLKYIPPKAKSHSSLS 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_001188534.1	7tm_4	44..>167	CDD:304433	36/124 (29%)
		7tm_1	53..363	CDD:278431	69/331 (21%)
		7tm_4	<310..380	CDD:304433	17/81 (21%)
Agtr1a	NP_112247.2	7tmA_AT1R	29..313	CDD:320320	76/363 (21%)
		TM helix 1	31..55	CDD:320320	8/23 (35%)
		TM helix 2	64..85	CDD:320320	9/21 (43%)
		TM helix 3	102..124	CDD:320320	2/21 (10%)
		TM helix 4	147..163	CDD:320320	4/15 (27%)
		TM helix 5	193..216	CDD:320320	5/22 (23%)
		TM helix 6	239..261	CDD:320320	6/21 (29%)
		TM helix 7	281..306	CDD:320320	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100