DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment moody and Gpr75

DIOPT Version :9

Sequence 1:	NP_001188534.1	Gene:	moody / 31168	FlyBaseID:	FBgn0025631	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_780699.2	Gene:	Gpr75 / 237716	MGIID:	2441843	Length:	540	Species:	Mus musculus

Alignment Length:	623	Identity:	126/623 - (20%)
Similarity:	209/623 - (33%)	Gaps:	161/623 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PPLEALTTMVPPADATGFSQSLLTF-----AAVMTFLIMIV---GICGNLLTVVALLKCPKVRNV 70
            |||..       .::|...:.|..|     ....|||:.|:   |..||.:..::... |..|..
Mouse    19 PPLHG-------GNSTSLQEGLRDFIHTATLVTCTFLLAIIFCLGSYGNFIVFLSFFD-PSFRKF 75

  Fly    71 AAAF---IISLCIADLLFCALVLP-FQGLRFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMIT 131
            ...|   |::|...||..|.:..| |..:.|...........|........|.:.:||..:|:|.
Mouse    76 RTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDSFCFTFHLTSSGFVIMSLKMVAVIA 140

  Fly   132 INRYVMITHHGLYARIYKR-----HWIAVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQT---- 187
            ::|..|:        :.|:     .:..:::....|::....|.||          :.|:|
Mouse   141 LHRLRMV--------MGKQPNCTASFSCILLLTLLLWATSFTLATL----------ATLRTNKSH 187

  Fly   188 -C---SIMTDDHGHSSKTTLFITAFVIPCLVIIACYAKIFWVVHKSEQ--RLKRHATKQNSIPNN 246
             |   |.:.|..| .:..:|::..|.....|:...|..|...:.|:.|  :.....|...|.|..
Mouse   188 LCLPMSSLMDGEG-KAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQP 251

  Fly   247 LRPLASTGSG-----ALPSGAECQPSNRVSSDSSSSFSIDVPE-TAPSGKQQP-------TRVKD 298
            ....:..|:|     .:|:....|..|::....:..::.::.: ..||..:..       :..||
Mouse   252 FMGASVKGNGDPIQCTMPALYRNQNYNKLQHSQTHGYTKNINQMPIPSASRLQLVSAINFSTAKD 316

  Fly   299 QREVRAKRNEWRITKMVLAIFLSFVVCYLPITIVKVADKNVEHPS-----LHICSYILLYLSACI 358
            .:.|        :|.:|  |.||.:||.||:.|..|.....::.|     ..:..:.|::..:.:
Mouse   317 SKAV--------VTCVV--IVLSVLVCCLPLGISLVQMVLSDNGSFILYQFELFGFTLIFFKSGL 371

  Fly   359 NPIIYVIMNKQYRK------AYKTVVF--CQPARLLLPFGKTN-----GASSAAEKWKDTGLSNN 410
            ||.||...:...|:      .|..:.|  |:....|...||.|     ..||..|......||..
Mouse   372 NPFIYSRNSAGLRRKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPK 436

  Fly   411 HSRTIVSQMSGGTGAASGAGTATGTAAVAVMQTPPEVQQAQALEMVSRGPDLISKSNLPQPNVTP 475
            ..|..|.|..|                      |...:::.|...||.|..
Mouse   437 PQRKFVDQACG----------------------PSHSKESAASPKVSAGHQ-------------- 465

  Fly   476 PPPSVLTATPNGSNSNSLTLRLPLKKNNHCYTNSGFNSSTPSPSSGLGIGISSSSIYRPGVGSLG 540
                     |.|.:|::     |:......| .|.:|||.....||        ....|.|.|.|
Mouse   466 ---------PCGQSSST-----PINTRIEPY-YSIYNSSPSQQESG--------PANLPPVNSFG 507

  Fly   541 SGSASIRRITMVGDDIILEEEELPPTPPATSAPTTPAP 578
            ..|:.|.......:|::.|.:       :|||...|.|
Mouse   508 FASSYIAMHYYTTNDLMQEYD-------STSAKQIPIP 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_001188534.1	7tm_4	44..>167	CDD:304433	27/134 (20%)
		7tm_1	53..363	CDD:278431	67/346 (19%)
		7tm_4	<310..380	CDD:304433	20/82 (24%)
Gpr75	NP_780699.2	7tmA_GPR75	44..387	CDD:320136	75/372 (20%)
		TM helix 1	44..70	CDD:320136	7/26 (27%)
		TM helix 2	79..104	CDD:320136	8/24 (33%)
		TM helix 3	118..148	CDD:320136	8/37 (22%)
		TM helix 4	159..181	CDD:320136	4/31 (13%)
		TM helix 5	199..228	CDD:320136	6/29 (21%)
		TM helix 6	314..344	CDD:320136	14/39 (36%)
		TM helix 7	355..380	CDD:320136	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475		10/81 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100