Protein Alignment moody and AGTR2

DIOPT Version :10

• Sequence 1: NP_569970.2
• Gene: moody / 31168
• FlyBaseID: FBgn0025631
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_000677.2
• Gene: AGTR2 / 186
• HGNCID: 338
• Length: 363
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 76/366 - (20%)
• Similarity: 139/366 - (37%)
• Gaps: 111/366 - (30%)

  Fly    41 VMTFLIMIVGICGNLLTVVALLKCPK-VRNVAAAFIISLCIADLLFCALVLP----FQGLRFVQG 100
            ::.::|.::|...|:: ||.|..|.| .:.|::.:|.:|.:||||..| .||    :...|:
Human    49 ILYYIIFVIGFLVNIV-VVTLFCCQKGPKKVSSIYIFNLAVADLLLLA-TLPLWATYYSYRY--- 108

  Fly   101 TWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYVMITHHGLYARIYKRHWIA-VMIAACWLFS 164
            .|..|.|:|::.......|:..|:..|..::::||..:.:..|..|  :..|.| .::...|..:
Human   109 DWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQR--RNPWQASYIVPLVWCMA 171

  Fly   165 YGMQLPTLLGEWGRFGYDSR------LQTCSIMTDDHGH---SSKTTLF--ITAFVIPCLVIIAC 218
            ....|||.      :..|.|      :..|.:......:   |:...|.  |..|:||.:.|..|
Human   172 CLSSLPTF------YFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATC 230

  Fly   219 YAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDVP 283
            |..|           ::|..|.||.
Human   231 YFGI-----------RKHLLKTNSY---------------------------------------- 244

  Fly   284 ETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSFVVCYLPITIVKVADKNVEHPSLHICS 348
                 ||.:.||  ||           :.||..|:.|:|::|:||..::...|.......::.|.
Human   245 -----GKNRITR--DQ-----------VLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCE 291

  Fly   349 YI------------LLYLSACINPIIYVIMNKQYRKAYKTV 377
            .|            |.:.::|:||.:|..:..::::..::|
Human   292 VIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSV 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_569970.2	7tmA_GPR84-like	37..374	CDD:320338	75/361 (21%)
		TM helix 1	38..64	CDD:320338	6/22 (27%)
		TM helix 2	71..94	CDD:320338	9/26 (35%)
		TM helix 3	109..139	CDD:320338	6/29 (21%)
		TM helix 4	153..171	CDD:320338	3/18 (17%)
		TM helix 5	196..305	CDD:320338	20/113 (18%)
		TM helix 6	306..336	CDD:320338	8/29 (28%)
		TM helix 7	342..367	CDD:320338	7/36 (19%)
AGTR2	NP_000677.2	7tmA_AT2R	45..329	CDD:341341	75/361 (21%)
		TM helix 1	46..72	CDD:341341	6/23 (26%)
		TM helix 2	79..104	CDD:341341	9/25 (36%)
		TM helix 3	117..147	CDD:341341	6/29 (21%)
		TM helix 4	158..182	CDD:341341	6/29 (21%)
		TM helix 5	208..237	CDD:341341	10/39 (26%)
		TM helix 6	249..279	CDD:341341	12/42 (29%)
		TM helix 7	297..322	CDD:341341	5/24 (21%)
		Helix VIII. /evidence=ECO:0000269|PubMed:28379944	324..333		1/9 (11%)