Protein Alignment moody and AGTR1

DIOPT Version :10

• Sequence 1: NP_569970.2
• Gene: moody / 31168
• FlyBaseID: FBgn0025631
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_000676.1
• Gene: AGTR1 / 185
• HGNCID: 336
• Length: 359
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 92/432 - (21%)
• Similarity: 163/432 - (37%)
• Gaps: 112/432 - (25%)

  Fly     8 SLEDGYPPLEALTTMVPPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAA 72
            |.|||   ::.:....|.|   |....:......:..:|.:|||.||.|.|:.:....|::.||:
Human     6 STEDG---IKRIQDDCPKA---GRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVAS 64

  Fly    73 AFIISLCIADLLFCALVLPFQGL-RFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYV 136
            .|:::|.:|||.| .|.||...: ..::..|..|..||::.......|:..|:..:..::|:||:
Human    65 VFLLNLALADLCF-LLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYL 128

  Fly   137 MITHHGLYARIYKRHWIA-VMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSK 200
            .|. |.:.:|:.:...:| |.....||.:....||.::.....|..::.:..|:.    |..|..
Human   129 AIV-HPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAF----HYESQN 188

  Fly   201 TTL--------FITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGA 257
            :||        .|..|:.|.|:|:..|. :.|                               .|
Human   189 STLPIGLGLTKNILGFLFPFLIILTSYT-LIW-------------------------------KA 221

  Fly   258 LPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSF 322
            |....|.|                        |.:|            ||: .|.|:::||.|.|
Human   222 LKKAYEIQ------------------------KNKP------------RND-DIFKIIMAIVLFF 249

  Fly   323 VVCYLPITIVKVADKNVEHPSLHIC------------SYILLYLSACINPIIYVIMNKQYRKAYK 375
            ...::|..|....|..::...:..|            :..:.|.:.|:||:.|..:.|::::
Human   250 FFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKR--- 311

  Fly   376 TVVFCQPARLLLPFGKTNGASSAAEKWKDTGLSNNHSRTIVS 417
              .|.|..:.:.|..|::...|.    |.:.||...|..:.|
Human   312 --YFLQLLKYIPPKAKSHSNLST----KMSTLSYRPSDNVSS 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_569970.2	7tmA_GPR84-like	37..374	CDD:320338	75/358 (21%)
		TM helix 1	38..64	CDD:320338	8/25 (32%)
		TM helix 2	71..94	CDD:320338	10/22 (45%)
		TM helix 3	109..139	CDD:320338	6/29 (21%)
		TM helix 4	153..171	CDD:320338	5/18 (28%)
		TM helix 5	196..305	CDD:320338	16/116 (14%)
		TM helix 6	306..336	CDD:320338	10/29 (34%)
		TM helix 7	342..367	CDD:320338	6/36 (17%)
AGTR1	NP_000676.1	7tmA_AT1R	29..313	CDD:320320	75/363 (21%)
		TM helix 1	30..56	CDD:320320	8/25 (32%)
		TM helix 2	63..88	CDD:320320	10/25 (40%)
		TM helix 3	101..131	CDD:320320	6/29 (21%)
		TM helix 4	144..165	CDD:320320	6/20 (30%)
		TM helix 5	192..221	CDD:320320	7/60 (12%)
		TM helix 6	233..263	CDD:320320	11/42 (26%)
		TM helix 7	281..306	CDD:320320	5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..359		4/13 (31%)