DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment moody and npr-25

DIOPT Version :9

Sequence 1:	NP_001188534.1	Gene:	moody / 31168	FlyBaseID:	FBgn0025631	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_505883.1	Gene:	npr-25 / 179570	WormBaseID:	WBGene00011381	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	454	Identity:	93/454 - (20%)
Similarity:	170/454 - (37%)	Gaps:	132/454 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GYPPLEALTTMVPPADATGFSQSLLTFAAVMTFLIMIVGICGN--LLTVVALLKCPKVRNVAA-- 72
            ||||        ||.....|:::.:.::....|     |..||  :|:.|..:......:|.|
Worm     9 GYPP--------PPLVGASFAKTAIPYSICFVF-----GTLGNTAVLSYVFFITRSLKSSVTALG 60

  Fly    73 ---AFIISLCIADLLFCALVLPFQGLRFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINR 134
               .:|::||..||| ..:.:||.....:...|..|:::|::...::..|...|...:..:..:|
Worm    61 NTFIYIVALCAVDLL-VTVSIPFSLSYMILNNWVFGELVCKIHFMLELSNKMCSTFILTALAFDR 124

  Fly   135 YVMITHHGLYARIYK-RH--WIAVMIAACWLFSYGMQLPTLL---------GEWGRFGYDSRLQT 187
            |:.|.|..: .||:: ||  :|..::|...||   :..|.:|         |::.....:.|.:.
Worm   125 YMAICHPEI-KRIHEMRHTIYITTILATLSLF---LISPVVLSARVTSFKSGQYFVSAKNERHEV 185

  Fly   188 CSIMTDDHGHSSKTTLFITAFVI------PCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNN 246
            ...|..| |.:.:..::::||:|      ||.::...||||.       .||:|
Worm   186 IRQMCID-GMALEWKVWVSAFLIFFAFLLPCTLLTYFYAKIV-------LRLRR----------- 231

  Fly   247 LRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRI 311
                                                        |:.|.::.:..:|      ||
Worm   232 --------------------------------------------QRRTMLQSRIPLR------RI 246

  Fly   312 TKMVLAIFLSFVVCYLPITIVKVAD---------KNVEHPSLHICSYILLYLSACINPIIYVIMN 367
            |...:|....::.|::|..:.::.:         .|.:..:....|::|.::||..|.|.|..:|
Worm   247 TIYTMAATFFYLSCHIPFWLPQIYNIFSTVLGHKMNPKVMTFTYYSHLLPFISAAFNWIFYARLN 311

  Fly   368 KQYRKAYKTVVFCQPARLLLPFGKT---NGASSAA----EKWKDTGLSNNHSRTIVSQMSGGTG 424
            .|::|....|.    .|::....|:   .|.|.||    .|:.|..|...|....:|..|...|
Worm   312 SQFKKGLVLVT----ERMIRKRTKSMHEKGYSEAAVELTSKFDDVPLMCPHCEAQLSIRSSSNG 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_001188534.1	7tm_4	44..>167	CDD:304433	33/132 (25%)
		7tm_1	53..363	CDD:278431	66/343 (19%)
		7tm_4	<310..380	CDD:304433	18/78 (23%)
npr-25	NP_505883.1	7tm_classA_rhodopsin-like	24..311	CDD:381740	69/365 (19%)
		TM helix 1	24..48	CDD:381740	6/28 (21%)
		TM helix 2	63..84	CDD:381740	8/21 (38%)
		TM helix 3	100..122	CDD:381740	2/21 (10%)
		TM helix 4	144..160	CDD:381740	4/18 (22%)
		TM helix 5	200..223	CDD:381740	5/22 (23%)
		TM helix 6	244..269	CDD:381740	7/30 (23%)
		TM helix 7	286..311	CDD:381740	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100