Protein Alignment moody and PROKR2

DIOPT Version :10

• Sequence 1: NP_569970.2
• Gene: moody / 31168
• FlyBaseID: FBgn0025631
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_658986.1
• Gene: PROKR2 / 128674
• HGNCID: 15836
• Length: 384
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 88/427 - (20%)
• Similarity: 163/427 - (38%)
• Gaps: 118/427 - (27%)

  Fly    14 PPLEALTTM----------VPPADATGFSQSLLTFAAVMTFLIMIVGI---C--GNLLTVVALLK 63
            ||.:..:::          :|..:....:::...|||.:...|.:.||   |  ||.:.:.||.:
Human    16 PPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTR 80

  Fly    64 CPKVRNVAAAFIISLCIADLLFCALVLPFQGLRFV--QGTWRHGQVLCRLIPFIQYGNIGVSLLC 126
            ..|:||:....|.:|.|:|.|...:..||:...:|  |.:|.||.|||..:.:::..::.||...
Human    81 YKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNA 145

  Fly   127 IAMITINRYVMITHHGLYARI-YKRHWIAVMIAACWLFSYGMQLPT--LLGEWGRFGYDSRLQT- 187
            :..|.|:||:.|. |.|..|: |:.  .:.:||..|:.|..:.:|:  ...|...|...|:.:.
Human   146 LLAIAIDRYLAIV-HPLKPRMNYQT--ASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIF 207

  Fly   188 CSIM--TDDHGHSSKTTLFI--TAFVIPCLVIIACYAKI---FWVVHKSEQRLKRHATKQNSIPN 245
            |..:  .|...:.....|||  ..||.|.:.:..|||:|   .|.
Human   208 CGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWF-------------------- 252

  Fly   246 NLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWR 310
                                                  :..|..:.:..|    :.:|.:|   :
Human   253 --------------------------------------KAVPGFQTEQIR----KRLRCRR---K 272

  Fly   311 ITKMVLAIFLSFVVCYLP---ITIVKVADKNVEHPSLHICSYILLYLSAC-------INPIIYVI 365
            ...:::.|..::|:|:.|   .|||:.....|.....|..:  ..|:..|       ||.:.:|.
Human   273 TVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLT--AFYVVECIAMSNSMINTVCFVT 335

  Fly   366 MNKQYRKAYKTVVFC--QPARLLLPFGKTNGASSAAE 400
            :.....|.:|.::..  :|::        .|:.|:|:
Human   336 VKNNTMKYFKKMMLLHWRPSQ--------RGSKSSAD 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_569970.2	7tmA_GPR84-like	37..374	CDD:320338	80/364 (22%)
		TM helix 1	38..64	CDD:320338	11/30 (37%)
		TM helix 2	71..94	CDD:320338	7/22 (32%)
		TM helix 3	109..139	CDD:320338	7/29 (24%)
		TM helix 4	153..171	CDD:320338	4/17 (24%)
		TM helix 5	196..305	CDD:320338	14/113 (12%)
		TM helix 6	306..336	CDD:320338	8/32 (25%)
		TM helix 7	342..367	CDD:320338	6/31 (19%)
PROKR2	NP_658986.1	7tmA_prokineticin-R	54..344	CDD:320332	77/359 (21%)
		TM helix 1	55..81	CDD:320332	8/25 (32%)
		TM helix 2	88..113	CDD:320332	7/24 (29%)
		TM helix 3	128..158	CDD:320332	7/29 (24%)
		TM helix 4	169..190	CDD:320332	5/22 (23%)
		TM helix 5	220..249	CDD:320332	10/28 (36%)
		TM helix 6	268..298	CDD:320332	8/32 (25%)
		TM helix 7	312..337	CDD:320332	5/26 (19%)