DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment moody and Agtr1a

DIOPT Version :9

Sequence 1:	NP_001188534.1	Gene:	moody / 31168	FlyBaseID:	FBgn0025631	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_796296.1	Gene:	Agtr1a / 11607	MGIID:	87964	Length:	359	Species:	Mus musculus

Alignment Length:	432	Identity:	92/432 - (21%)
Similarity:	163/432 - (37%)	Gaps:	124/432 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLEDGYPPLEALTTMVPPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAA 72
            |.|||   ::.:....|.|   |....:......:..:|.:|||.||.|.|:.:....|::.||:
Mouse     6 STEDG---IKRIQDDCPRA---GRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVAS 64

  Fly    73 AFIISLCIADLLFCALVLPFQGL-RFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYV 136
            .|:::|.:|||.| .|.||...: ..::..|..|..||::.......|:..|:..:..::|:||:
Mouse    65 VFLLNLALADLCF-LLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYL 128

  Fly   137 MITHHGLYARIYKRHWIA-VMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSK 200
            .|. |.:.:|:.:...:| |.....||.:....||.::.....|..::.:..|:.    |..|..
Mouse   129 AIV-HPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAF----HYESRN 188

  Fly   201 TTL--------FITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGA 257
            :||        .|..|:.|.|:|:..|. :.|                               .|
Mouse   189 STLPIGLGLTKNILGFLFPFLIILTSYT-LIW-------------------------------KA 221

  Fly   258 LPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSF 322
            |....|.|                        |.:|            ||: .|.::::||.|.|
Mouse   222 LKKAYEIQ------------------------KNKP------------RND-DIFRIIMAIVLFF 249

  Fly   323 VVCYLPITIVKVADKNVEHPSLHIC------------SYILLYLSACINPIIYVIMNKQYRKAYK 375
            ...::|..|....|..::...:|.|            :..:.|.:.|:||:.|..:.|:::|
Mouse   250 FFSWVPHQIFTFLDVLIQLGVIHDCKIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKK--- 311

  Fly   376 TVVFCQPARLLLPFGKTNGA----------------SSAAEK 401
              .|.|..:.:.|..|::.:                ||||:|
Mouse   312 --YFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSAAKK 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
moody	NP_001188534.1	7tm_4	44..>167	CDD:304433	36/124 (29%)
		7tm_1	53..363	CDD:278431	69/331 (21%)
		7tm_4	<310..380	CDD:304433	17/81 (21%)
Agtr1a	NP_796296.1	7tmA_AT1R	29..313	CDD:320320	76/363 (21%)
		TM helix 1	30..56	CDD:320320	8/25 (32%)
		TM helix 2	63..88	CDD:320320	10/25 (40%)
		TM helix 3	101..131	CDD:320320	6/29 (21%)
		TM helix 4	144..165	CDD:320320	6/20 (30%)
		TM helix 5	192..221	CDD:320320	7/60 (12%)
		TM helix 6	233..263	CDD:320320	10/42 (24%)
		TM helix 7	281..306	CDD:320320	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..359		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100