Protein Alignment Actn and ACTN2

DIOPT Version :10

• Sequence 1: NP_477485.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001094.1
• Gene: ACTN2 / 88
• HGNCID: 164
• Length: 894
• Species: Homo sapiens
• Alignment Length: 918
• Identity: 615/918 - (66%)
• Similarity: 749/918 - (81%)
• Gaps: 30/918 - (3%)

  Fly     3 MENGLSMEY---GDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRN 64
            :|.|:...|   .|.||.|||||:|:.||||||||||:||||||||||||||||.|:||||||||
Human     4 IEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRN 68

  Fly    65 GLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGM 129
            ||||||||||||||.||||||||||||||||||||||:||||||.|||||||||||||:||||||
Human    69 GLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGM 133

  Fly   130 IWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLI 194
            |||||||||||||||||.:||||||||||||||||:|||:||||.|:||||..||||||||||||
Human   134 IWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLI 198

  Fly   195 DYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVG 259
            ||:||:||:|:.|:|.|.::|||:||||:|||.:|::||||||||||||||||:||||.||:|
Human   199 DYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQ-- 261

  Fly   260 NVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNS 324
                                ||||||||||||.|||||||||||||||||:||||||||:|||.:
Human   262 --------------------AETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLEN 306

  Fly   325 RQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDI 389
            |..:.::..:|||||::|.||||||||:|::|.:||.||||||||||:|||||::|:|||.||||
Human   307 RTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDI 371

  Fly   390 SNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNE 454
            :.:|:.||.|||.:|||||.|..|||||||||:||:.||..||.|..|||::|..:|:....|.|
Human   372 AGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436

  Fly   455 LKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRR 519
            ::||.:|||||||||||||||||||||||||||.|:|||.|:||.|||:|||||||||.|||:||
Human   437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRR 501

  Fly   520 TALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLG 584
            .||:..|::||.||.|||||||||||||||::|..|||.||||||::||||.||.||:||||||.
Human   502 EALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP 566

  Fly   585 EADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRK 649
            |||.|...|:.:..|||.:::.:.|.....|||:|:|.:::..||..|:||||.|||:|..||.:
Human   567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631

  Fly   650 QQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELE 714
            |..||.||||||.:||.:||||:.:|:.:....:.:.|:||||:::||:||..:..||.||::||
Human   632 QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLE 696

  Fly   715 KIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSS 779
            ..||.:||:::|:|::||||||.:|||||.|||:|.|.|||||.||||||:|||:|||:||||:|
Human   697 GDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRAS 761

  Fly   780 FNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRE 844
            |||||:.:.|.:..|:|::||:|:||.:     |:.:|.||:.:||||..|.|.|.:|:||||||
Human   762 FNHFDRRKNGLMDHEDFRACLISMGYDL-----GEAEFARIMTLVDPNGQGTVTFQSFIDFMTRE 821

  Fly   845 STDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFST 909
            :.|||||||||.||||||:||||||.:|||||||||||:|||:|||.|.||..|||||||.:||:
Human   822 TADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSS 886

  Fly   910 ALYGETDL 917
            |||||:||
Human   887 ALYGESDL 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_477485.1	CH_ACTN_rpt1	31..135	CDD:409063	96/103 (93%)
		CH_ACTN_rpt2	139..252	CDD:409065	87/112 (78%)
		SPEC	302..525	CDD:238103	151/222 (68%)
		SPEC	420..647	CDD:238103	140/226 (62%)
		SPEC	538..760	CDD:238103	121/221 (55%)
		EFh	775..842	CDD:238008	31/66 (47%)
		EFhand_Ca_insen	847..913	CDD:430177	52/65 (80%)
ACTN2	NP_001094.1	Actin-binding	1..254		202/249 (81%)
		CH_ACTN_rpt1	35..139	CDD:409063	96/103 (93%)
		CH_ACTN_rpt2	143..257	CDD:409065	88/113 (78%)
		Spectrin 1	281..391		74/109 (68%)
		Spectrin	281..391	CDD:395348	74/109 (68%)
		Spectrin 2	401..506		72/104 (69%)
		SPEC	402..629	CDD:238103	140/226 (62%)
		Spectrin 3	516..627		64/110 (58%)
		Spectrin 4	637..740		54/102 (53%)
		Spectrin	637..739	CDD:395348	53/101 (52%)
		PTZ00184	747..>851	CDD:185504	64/108 (59%)
		EFhand_Ca_insen	824..890	CDD:430177	52/65 (80%)