DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and ACTN1

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_016877209.1	Gene:	ACTN1 / 87	HGNCID:	163	Length:	1106	Species:	Homo sapiens

Alignment Length:	1128	Identity:	617/1128 - (54%)
Similarity:	745/1128 - (66%)	Gaps:	234/1128 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MMENGLSMEYG--DGY-----------------MEQEEEWEREGLLDPAW--EKQQKK------T 39
            |:.|||.:..|  ||.                 ..:||.::.|......|  ||..|:      |
Human     1 MVSNGLQVRVGVRDGARNPCRKADNCHQGIGKGKRKEEAYKSENPKKLKWLGEKTLKRPWSTSET 65

  Fly    40 FTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIA 104
            ||||||||||||||.|:|||||||:||||||||||||||.|.||:|||||.|||:||||||||||
Human    66 FTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIA 130

  Fly   105 SKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNV 169
            ||||.|||||||||||||:|||||||||||||||||||||||.:||||||||||||||||||||:
Human   131 SKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNI 195

  Fly   170 QNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTP 234
            ||||:|:||||.||||||||||:||||.||.||:||.||||||||||||||||:|||.:|::.|.
Human   196 QNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTA 260

  Fly   235 KPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENER 299
            :|||:|||||||.:||||.|||:                      ||||||||||||.||||||:
Human   261 RPDEKAIMTYVSSFYHAFSGAQK----------------------AETAANRICKVLAVNQENEQ 303

  Fly   300 LMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFN 364
            |||:||:||||||||||||:|||.:|..:|::..:|:|||::|.|||.||||:|::|.:||.|||
Human   304 LMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 368

  Fly   365 TLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKAD 429
            |||||||||||||::|:||:.||||:|:|..||..||.:|||||.|..|||||:|||:||:.||.
Human   369 TLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKAS 433

  Fly   430 AHEDWT--------RGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQEL 486
            .||.||        .|||.||:.:|:....|:|:|||.|||||||||||||||||||||||||||
Human   434 IHEAWTDAMWPSLNPGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQEL 498

  Fly   487 NTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLD 551
            |.|:|:|..|||||||:||||||.||||||:||.||:..|::||.||.|:||:||||||||||::
Human   499 NELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWME 563

  Fly   552 GTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENP 616
            |..|||.|.|||||:||||||..||:||||||.:||||...|:.:..||..||:.:.:.....||
Human   564 GAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNP 628

  Fly   617 YTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAI 681
            |||:|..::..||..||||||:|||.|..|..:||:||.||:||..:||::||||:.:|:.:..|
Human   629 YTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRI 693

  Fly   682 GMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLL 746
            .:.:.|:|||||..|::||:::..|||.|::||..||.:||::||:|::||||||.:||||||||
Human   694 SIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 758

  Fly   747 TSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDR 811
            |:|.|.||||||||||||:|||||||:||||:||||||::.:|.|.|||||:||:||||.||.|.
Human   759 TTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDP 823

  Fly   812 Q---------------------------------------------------------------- 812
            |
Human   824 QVLASCMEHAQGWRLGQEIMRFSFFSSLCLDLLSPSCGPWGSSSPAVSVCPITGPPSALCCLSWQ 888

  Fly   813 ----------------------------------------------------------------- 812

Human   889 PTGCPLSSVLAALHPMGGFLHLPALSSSCLWTFPPMCVRIFSYVPLPILTPKTINLIPVLAICSC 953

  Fly   813 ------------------------------------------------GDLDFQRILAVVDPNNT 829
                                                            |:.:|.||:::||||..
Human   954 LPGPGPALPLPAFPTLLVSWYHCPPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRL 1018

  Fly   830 GYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKG 894
            |.|.|.||:|||:||:.|||||:||:.||:|||.||.||..||||||||||||||||.||.||.|
Human  1019 GVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTG 1083

  Fly   895 PNGVPGALDYMSFSTALYGETDL 917
            |:.|||||||||||||||||:||
Human  1084 PDSVPGALDYMSFSTALYGESDL 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	89/111 (80%)
		CH_ACTN_rpt2	139..252	CDD:409065	90/112 (80%)
		SPEC	302..525	CDD:238103	152/230 (66%)
		SPEC	420..647	CDD:238103	144/234 (62%)
		SPEC	538..760	CDD:238103	124/221 (56%)
		EFh	775..842	CDD:238008	41/243 (17%)
		EFhand_Ca_insen	847..913	CDD:400872	52/65 (80%)
ACTN1	XP_016877209.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142158
Domainoid	1	1.000	197	1.000	Domainoid score	I3094
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1288	1.000	Inparanoid score	I162
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54323
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	1	1.000	-	-		FOG0000815
OrthoInspector	1	1.000	-	-		otm41824
orthoMCL	1	0.900	-	-		OOG6_101135
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R34
SonicParanoid	1	1.000	-	-		X512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800