Protein Alignment Actn and Actn1

DIOPT Version :10

• Sequence 1: NP_477485.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_038968920.1
• Gene: Actn1 / 81634
• RGDID: 70907
• Length: 914
• Species: Rattus norvegicus
• Alignment Length: 937
• Identity: 623/937 - (66%)
• Similarity: 754/937 - (80%)
• Gaps: 45/937 - (4%)

  Fly     3 MENGLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLK 67
            |::..|.:..| ||:.||:|:|:.||||||||||:||||||||||||||||.|:|||||||:|||
  Rat     1 MDHYDSQQTND-YMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLK 64

  Fly    68 LMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWT 132
            |||||||||||.|.||:|||||.|||:||||||||||||||.|||||||||||||:|||||||||
  Rat    65 LMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 129

  Fly   133 IILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYA 197
            ||||||||||||||.:||||||||||||||||||||:||||:|:||||.||||||||||:||||.
  Rat   130 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYG 194

  Fly   198 KLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVT 262
            ||.||:||.||||||||||:|||||:|||.:|::.|.:|||:|||||||.:||||.|||:
  Rat   195 KLRKDDPLTNLNTAFDVAERYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQK----- 254

  Fly   263 HVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQA 327
                             ||||||||||||.||||||:|||:||:||||||||||||:|||.:|..
  Rat   255 -----------------AETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVP 302

  Fly   328 DNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNS 392
            :|::..:|:|||::|.|||.||||:|::|.:||.||||||||||||||||::|:||:.||||:|:
  Rat   303 ENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367

  Fly   393 WKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKA 457
            |..||.|||.:|||||.|..|||||:|||:||:.||..||.||.|||.||:.:|:....|:|:||
  Rat   368 WGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKA 432

  Fly   458 LKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTAL 522
            |.||||||||||||||||||||||||||||.|:|:|..|||||||:||||||.||||||:||.||
  Rat   433 LLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREAL 497

  Fly   523 DEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEAD 587
            :..|::||.||.|:||:||||||||||::|..|||.|.|||||:||||||..||:||||||.:||
  Rat   498 ERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562

  Fly   588 KEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQN 652
            ||...|:.:..||..||:.:.:.....|||||:|..::..||..||||||:|||.|..|..:||:
  Rat   563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQH 627

  Fly   653 NEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIH 717
            ||.||:||..:||::||||:.:|:.:..|.:.:.|:|||||..|::||:::..|||.|::||..|
  Rat   628 NERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

  Fly   718 QAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNH 782
            |.:||::||:|::||||||.:|||||||||:|.|.||||||||||||:|||||||:||||:||||
  Rat   693 QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNH 757

  Fly   783 FDKNRTGRLSPEEFKSCLVSLGYSIGKDRQ----------------------GDLDFQRILAVVD 825
            ||::.:|.|.|||||:||:||||.||.|.|                      |:.:|.||:::||
  Rat   758 FDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVD 822

  Fly   826 PNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMP 890
            ||..|.|.|.||:|||:||:.|||||:||:.||:|||.||.||..||||||||||||||||.||.
  Rat   823 PNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMA 887

  Fly   891 PYKGPNGVPGALDYMSFSTALYGETDL 917
            ||.||:.|||||||||||||||||:||
  Rat   888 PYAGPDSVPGALDYMSFSTALYGESDL 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_477485.1	CH_ACTN_rpt1	31..135	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	139..252	CDD:409065	89/112 (79%)
		SPEC	302..525	CDD:238103	153/222 (69%)
		SPEC	420..647	CDD:238103	144/226 (64%)
		SPEC	538..760	CDD:238103	124/221 (56%)
		EFh	775..842	CDD:238008	41/88 (47%)
		EFhand_Ca_insen	847..913	CDD:430177	52/65 (80%)
Actn1	XP_038968920.1	CH_ACTN_rpt1	28..132	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	136..250	CDD:409065	90/113 (80%)
		SPEC	277..498	CDD:238103	152/220 (69%)
		SPEC	395..622	CDD:238103	144/226 (64%)
		Spectrin	634..733	CDD:395348	53/98 (54%)
		EFh	750..839	CDD:238008	41/88 (47%)
		EFhand_Ca_insen	844..910	CDD:430177	52/65 (80%)