DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and Actn1

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_038968920.1	Gene:	Actn1 / 81634	RGDID:	70907	Length:	914	Species:	Rattus norvegicus

Alignment Length:	937	Identity:	623/937 - (66%)
Similarity:	754/937 - (80%)	Gaps:	45/937 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MENGLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLK 67
            |::..|.:..| ||:.||:|:|:.||||||||||:||||||||||||||||.|:|||||||:|||
  Rat     1 MDHYDSQQTND-YMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLK 64

  Fly    68 LMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWT 132
            |||||||||||.|.||:|||||.|||:||||||||||||||.|||||||||||||:|||||||||
  Rat    65 LMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWT 129

  Fly   133 IILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYA 197
            ||||||||||||||.:||||||||||||||||||||:||||:|:||||.||||||||||:||||.
  Rat   130 IILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYG 194

  Fly   198 KLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVT 262
            ||.||:||.||||||||||:|||||:|||.:|::.|.:|||:|||||||.:||||.|||:
  Rat   195 KLRKDDPLTNLNTAFDVAERYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQK----- 254

  Fly   263 HVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQA 327
                             ||||||||||||.||||||:|||:||:||||||||||||:|||.:|..
  Rat   255 -----------------AETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVP 302

  Fly   328 DNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNS 392
            :|::..:|:|||::|.|||.||||:|::|.:||.||||||||||||||||::|:||:.||||:|:
  Rat   303 ENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNA 367

  Fly   393 WKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKA 457
            |..||.|||.:|||||.|..|||||:|||:||:.||..||.||.|||.||:.:|:....|:|:||
  Rat   368 WGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKA 432

  Fly   458 LKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTAL 522
            |.||||||||||||||||||||||||||||.|:|:|..|||||||:||||||.||||||:||.||
  Rat   433 LLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREAL 497

  Fly   523 DEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEAD 587
            :..|::||.||.|:||:||||||||||::|..|||.|.|||||:||||||..||:||||||.:||
  Rat   498 ERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562

  Fly   588 KEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQN 652
            ||...|:.:..||..||:.:.:.....|||||:|..::..||..||||||:|||.|..|..:||:
  Rat   563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQH 627

  Fly   653 NEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIH 717
            ||.||:||..:||::||||:.:|:.:..|.:.:.|:|||||..|::||:::..|||.|::||..|
  Rat   628 NERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

  Fly   718 QAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNH 782
            |.:||::||:|::||||||.:|||||||||:|.|.||||||||||||:|||||||:||||:||||
  Rat   693 QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNH 757

  Fly   783 FDKNRTGRLSPEEFKSCLVSLGYSIGKDRQ----------------------GDLDFQRILAVVD 825
            ||::.:|.|.|||||:||:||||.||.|.|                      |:.:|.||:::||
  Rat   758 FDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVD 822

  Fly   826 PNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMP 890
            ||..|.|.|.||:|||:||:.|||||:||:.||:|||.||.||..||||||||||||||||.||.
  Rat   823 PNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMA 887

  Fly   891 PYKGPNGVPGALDYMSFSTALYGETDL 917
            ||.||:.|||||||||||||||||:||
  Rat   888 PYAGPDSVPGALDYMSFSTALYGESDL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	139..252	CDD:409065	89/112 (79%)
		SPEC	302..525	CDD:238103	153/222 (69%)
		SPEC	420..647	CDD:238103	144/226 (64%)
		SPEC	538..760	CDD:238103	124/221 (56%)
		EFh	775..842	CDD:238008	41/88 (47%)
		EFhand_Ca_insen	847..913	CDD:400872	52/65 (80%)
Actn1	XP_038968920.1	CH_ACTN_rpt1	28..132	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	136..250	CDD:409065	90/113 (80%)
		SPEC	277..498	CDD:238103	152/220 (69%)
		SPEC	395..622	CDD:238103	144/226 (64%)
		Spectrin	634..733	CDD:395348	53/98 (54%)
		EFh	750..839	CDD:238008	41/88 (47%)
		EFhand_Ca_insen	844..910	CDD:400872	52/65 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335882
Domainoid	1	1.000	165	1.000	Domainoid score	I3817
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1289	1.000	Inparanoid score	I151
OMA	1	1.010	-	-		QHG54323
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	1	1.000	-	-		FOG0000815
OrthoInspector	1	1.000	-	-		otm45963
orthoMCL	1	0.900	-	-		OOG6_101135
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X512
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910