DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and ACTN4

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_016882820.1	Gene:	ACTN4 / 81	HGNCID:	166	Length:	933	Species:	Homo sapiens

Alignment Length:	934	Identity:	617/934 - (66%)
Similarity:	747/934 - (79%)	Gaps:	47/934 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLML 70
            |.||  || ||.||::|:|:.||||||||||:||||||||||||||||.|:||:||||:||||||
Human    25 GGSM--GD-YMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLML 86

  Fly    71 LLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIIL 135
            ||||||||.||||:|||||.|||.||||||||||||||.|||||||||||||.||||||||||||
Human    87 LLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIIL 151

  Fly   136 RFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLS 200
            |||||||||||.:|||||||||||||||||||||||||:|:||||||.||||||||:||:|.||.
Human   152 RFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLR 216

  Fly   201 KDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVP 265
            ||:|:.|||.||:|||||||||:|||.:|::||.:|||:|||||||.:||||.|||:
Human   217 KDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQK-------- 273

  Fly   266 EPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNS 330
                          ||||||||||||.||||||.|||:||:||||||||||||:|||..|....:
Human   274 --------------AETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT 324

  Fly   331 LAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKG 395
            :..:|:|||::|.|||.||||:|::|.:||.||||||||||||||||::|:|||.||||:|.|:.
Human   325 IQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389

  Fly   396 LELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKK 460
            ||.|||.:|||||.|..|||||:|||:||:.||..||.||.|||.||:.:|:....|:::|||.:
Human   390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIR 454

  Fly   461 KHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEA 525
            |||||||||||||||||||||||||||.|:|:|..:||.|||:||||||.||:||..||.||::.
Human   455 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT 519

  Fly   526 ERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEF 590
            |:.||.||.||||:||||||||||::...|||.|||||||:|||:|||.||||||:||.:||:|.
Human   520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRER 584

  Fly   591 NLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEM 655
            ..|:.:.:|.:.|.:.:.|.....|||||:|...:..||..|:||||:||..|..|..|||:||.
Human   585 EAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649

  Fly   656 LRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAV 720
            ||||||.:||:|||||:.:|:.:..|.:.:.|:|||||..||:||:::..||||::.||:.||.:
Human   650 LRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLI 714

  Fly   721 QESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDK 785
            ||::||:|::||||||.:|||||||||:|.|.||||||||||||:|||||||:.|||:|||||||
Human   715 QEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDK 779

  Fly   786 NRTGRLSPEEFKSCLVSLGYSIGKDRQ----------------------GDLDFQRILAVVDPNN 828
            :..|.|.|||||:||:||||.:..|||                      |:.:|.||:::||||:
Human   780 DHGGALGPEEFKACLISLGYDVENDRQKQTGSMDSDDFRALLISTGYSLGEAEFNRIMSLVDPNH 844

  Fly   829 TGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYK 893
            :|.|.|.||:|||:||:||||||:|||.||::||.||.:|..:|||||||||||||||.||.||:
Human   845 SGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQ 909

  Fly   894 GPNGVPGALDYMSFSTALYGETDL 917
            ||:.|||||||.|||||||||:||
Human   910 GPDAVPGALDYKSFSTALYGESDL 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	139..252	CDD:409065	88/112 (79%)
		SPEC	302..525	CDD:238103	147/222 (66%)
		SPEC	420..647	CDD:238103	135/226 (60%)
		SPEC	538..760	CDD:238103	125/221 (57%)
		EFh	775..842	CDD:238008	41/88 (47%)
		EFhand_Ca_insen	847..913	CDD:400872	49/65 (75%)
ACTN4	XP_016882820.1	CH_ACTN_rpt1	47..151	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	155..269	CDD:409065	89/113 (79%)
		SPEC	296..517	CDD:238103	146/220 (66%)
		SPEC	414..640	CDD:238103	135/225 (60%)
		SPEC	532..754	CDD:238103	125/221 (57%)
		PTZ00184	759..>890	CDD:185504	68/130 (52%)
		EFhand_Ca_insen	863..929	CDD:400872	49/65 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3916
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1288	1.000	Inparanoid score	I162
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54323
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	1	1.000	-	-		FOG0000815
OrthoInspector	1	1.000	-	-		otm41824
orthoMCL	1	0.900	-	-		OOG6_101135
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840