DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and CLMN

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_011535460.1	Gene:	CLMN / 79789	HGNCID:	19972	Length:	1033	Species:	Homo sapiens

Alignment Length:	1007	Identity:	224/1007 - (22%)
Similarity:	370/1007 - (36%)	Gaps:	296/1007 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EEEW-EREGL-----------LDPAWEKQQKKTFTAWCNSHLRKAGTAID--NIEEDFRNGLKLM 69
            |.:| :||.|           |....|..||:|||.|.|.||.|....::  ::..|.::|..||
Human     5 EWDWFQREELIGQISDIRVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILM 69

  Fly    70 LLLEVISGETLPKPDRGKM-RFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTI 133
            .||||:||..|....:... |..::.|:.|||.|:....|.||||.|.||.|||..:.||:||.|
Human    70 ALLEVLSGRNLLHEYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNI 134

  Fly   134 ILRFAIQD--------------------------------------ISV-EEMTAKEGLLLWCQR 159
            ||.|.|::                                      ||| ::..|.:.||.|.||
Human   135 ILFFQIKELTGNLSRNSPSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWVQR 199

  Fly   160 KTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRM 224
            ||..| .|.||:|..|::.||||.|:|....|.|:|..:..:::..|||..||.:|:..|.|||:
Human   200 KTRKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQDALHIPRL 263

  Fly   225 LDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICK 289
            |:|:|:: ...|||::|||||:.:...|...:.........|...:.|:|...   ||.:.:..|
Human   264 LEPEDIM-VDTPDEQSIMTYVAQFLERFPELEAEDIFDSDKEVPIESTFVRIK---ETPSEQESK 324

  Fly   290 VLKVNQENERL-----------------------MEEY-------ERLASDLLEWIRRTMPW--- 321
            |..:.:..||.                       |:|:       ..|:....|::.:.:..
Human   325 VFVLTENGERTYTVNHETSHPPPSKVFVCDKPESMKEFRLDGVSSHALSDSSTEFMHQIIDQVLQ 389

  Fly   322 ------------------LNSRQAD---NSLAGVQKKLE-EYRTYRRK----------HKPPRVE 354
                              |:||:.:   |||. ::|.:. |..||:..          ...|||
Human   390 GGPGKTSDISEPSPESSILSSRKENGRSNSLP-IKKTVHFEADTYKDPFCSKNLSLCFEGSPRV- 452

  Fly   355 QKAKLETNFNTL--------QTKLRLSNRPAYLPTEGKTVSDI-----------SNSWKG-LELA 399
            .|..|..:.:.|        :.|...|..|.  .:..|...||           |:|..| ||..
Human   453 AKESLRQDGHVLAVEVAEEKEQKQESSKIPE--SSSDKVAGDIFLVEGTNNNSQSSSCNGALEST 515

  Fly   400 EKAFEE----------WLLAET-------MRLERLEH-----------------------LAQKF 424
            .:..||          .::|::       |.:|.||.                       .:|.|
Human   516 ARHDEESHSLSPPGENTVMADSFQIKVNLMTVEALEEGDYFEAIPLKASKFNSDLIDFASTSQAF 580

  Fly   425 KHKADAHEDWTRGKEEMLQSQDFRQCKLNE--LKALKKKHEAFESDL-----AAHQDRVEQ---- 478
            ......||  |:..|:....::..: ||.:  :|:..||.::.|..:     ..|||..|:
Human   581 NKVPSPHE--TKPDEDAEAFENHAE-KLGKRSIKSAHKKKDSPEPQVKMDKHEPHQDSGEEAEGC 642

  Fly   479 ------------------------------------IAAIAQELNTLEYHDCVSVNARCQRICDQ 507
                                                :..:.:||::.....|||:
Human   643 PSAPEETPVDKKPEVHEKAKRKSTRPHYEEEGEDDDLQGVGEELSSSPPSSCVSL---------- 697

  Fly   508 WDRLGALTQRRRTALD-EAERILEKIDILHLE---FAKRAAPFNNWLDGTREDLVDMFIVH-TME 567
             :.||:.::.   .|| :....|.|:.::..:   |.....|....|:...||..|:.... .:|
Human   698 -ETLGSHSEE---GLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVLEAYVEDPEDLKNEEMDLE 758

  Fly   568 EIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDV 632
            |.:|.:...|..:.   |||...:       ...|.|....:|...:...........|...|:.
Human   759 EPEGYMPDLDSREE---EADGSQS-------SSSSSVPGESLPSASDQVLYLSRGGVGTTPASEP 813

  Fly   633 RQLVPQRDQTLANELRKQQNNEMLRRQFAEK---ANIVGPWIERQMDAVTAIGMGLQGSLEDQLH 694
            ..|.|..|.   .:...::|:.|...|..|.   .||..|..|.    ||.  ..:....:::..
Human   814 APLAPHEDH---QQRETKENDPMDSHQSQESPNLENIANPLEEN----VTK--ESISSKKKEKRK 869

  Fly   695 RLKEYEQAVYAYKPNIEELEKIHQ-----------AVQESMIFENRYTNYTMETLRVGWEQLLTS 748
            .:...|.:::....:::..:.:.:           :..:|.|:..|:|:.:.|:....:.||..:
Human   870 HVDHVESSLFVAPGSVQSSDDLEEDSSDYSIPSRTSHSDSSIYLRRHTHRSSESDHFSYVQLRNA 934

  Fly   749 INRNINEVENQILTRDSKGISQEQLNEFRSSF 780
              .::::..|:||||    .|.::|.|....|
Human   935 --ADLDDRRNRILTR----YSTQKLTELILQF 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	44/106 (42%)
		CH_ACTN_rpt2	139..252	CDD:409065	48/151 (32%)
		SPEC	302..525	CDD:238103	62/372 (17%)
		SPEC	420..647	CDD:238103	48/278 (17%)
		SPEC	538..760	CDD:238103	40/239 (17%)
		EFh	775..842	CDD:238008	2/6 (33%)
		EFhand_Ca_insen	847..913	CDD:400872
CLMN	XP_011535460.1	CH	33..134	CDD:278723	42/100 (42%)
CLMN	XP_011535460.1	CH	191..286	CDD:278723	43/96 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920