DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Actn and SPTBN2

DIOPT Version :9

Sequence 1:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster
Sequence 2:XP_006718732.1 Gene:SPTBN2 / 6712 HGNCID:11276 Length:2397 Species:Homo sapiens


Alignment Length:1198 Identity:343/1198 - (28%)
Similarity:498/1198 - (41%) Gaps:359/1198 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MMENGLSMEYGDGYMEQEEEWER--EG-------LLDPA----------------------WEKQ 35
            |..||:|..:|:|..|..|.:..  ||       ||.||                      .|..
Human     1 MNGNGVSRVHGNGLHEASEFYYEAVEGAHNPGGLLLSPAAFINPAQYASVLEGRFKQLQDEREAV 65

  Fly    36 QKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKAL 100
            ||||||.|.||||.:....:.::..|.|:|..|:.||||:|||.||||.:|:||.|.:.||:|||
Human    66 QKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKAL 130

  Fly   101 DFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EEMTAKEGLLLWCQR 159
            .|:..:.|||.::|:.:|||||.::|||::|||||||.||||||      |:.:||:.||||||.
Human   131 QFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQM 195

  Fly   160 KTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRM 224
            |||.|.||||.||..|::|||||.|::|:|||||:|:..|.|.|...||..||::|||.|.:.::
Human   196 KTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKL 260

  Fly   225 LDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICK 289
            |||:| :|..:|||::|:|||:.|||.|...:.:.                      ....||.|
Human   261 LDPED-VNVDQPDEKSIITYVATYYHYFSKMKALA----------------------VEGKRIGK 302

  Fly   290 VLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVE 354
            ||....|.|||:|:||.|||:||:||.:|:..||.||..|||:|||.:|:.:.:||...|||:..
Human   303 VLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFT 367

  Fly   355 QKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEH 419
            :|..||....|:|:|||.:|:..|.|.||:.:|||:.:|:.||.||...|..|..|.:|.|:||.
Human   368 EKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQ 432

  Fly   420 LAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQ 484
            ||.:|..||...|.|. .:.:.|.|||....:|..::|..:||||.|:|:.|:..||:.:.|:|.
Human   433 LAARFDRKAAMRETWL-SENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAA 496

  Fly   485 ELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNW 549
            ||....|||...:.||...:...||.|..:...||      ||:|     |:||..|        
Human   497 ELAAERYHDIKRIAARQHNVARLWDFLRQMVAARR------ERLL-----LNLELQK-------- 542

  Fly   550 LDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLG-----------EAD---------------- 587
               ..:||  ::::..|||::|.:|:.|..:...|           |||                
Human   543 ---VFQDL--LYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASAL 602

  Fly   588 ------KEF---------NLIVNL------------------------------VREVESIVKQH 607
                  ||:         ..:..|                              |.|.|:.|::.
Human   603 RFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQ 667

  Fly   608 Q-----------IPGGLE--NPYTTL----------------------------------TANDM 625
            |           :.|.|.  |.:|.|                                  .|.::
Human   668 QHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL 732

  Fly   626 TRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMG------ 684
            ..:|..:..|..:|.|.||......        ||...||.:..|:...:..|::..:|      
Human   733 QAQWERLEALAEERAQRLAQAASLY--------QFQADANDMEAWLVDALRLVSSPELGHDEFST 789

  Fly   685 -----LQGSLEDQ---------------------LHRLKEYEQAVYAYKPNIEELEKIHQAVQES 723
                 ...:||::                     |.|..|.:..|...:.:.|||:.  :|.:.:
Human   790 QALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQA--RAGERA 852

  Fly   724 MIFENRYTNYTM-------------------------------------ETLRVGWEQLLTSINR 751
            ...|.....|||                                     |||......|...|..
Human   853 RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITA 917

  Fly   752 NINEVENQILTRDSKG-----ISQEQLNEFRSSFNHFDKNR----TGRLSPEEF----------- 796
             :|::..|:|..:..|     .:|||||.....|......:    |..||.:.:           
Human   918 -VNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWM 981

  Fly   797 --KSCLVSLGYSIGKDRQGDLDFQRILAVVDPN-------------------------------- 827
              |:.::.....:|.|..|.|..||.||..:.:                                
Human   982 REKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINAR 1046

  Fly   828 ----NTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQR 888
                .||:....|   .|.|.......|.::.|..|.|         |:.:..|...|.....: 
Human  1047 LREVQTGWEDLRA---TMRRREESLGEARRLQDFLRSL---------DDFQAWLGRTQTAVASE- 1098

  Fly   889 MPPYKGPNGVPGALDYMSFSTALYGETD 916
                :||..:|.|...::...||.||.:
Human  1099 ----EGPATLPEAEALLAQHAALRGEVE 1122

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 53/125 (42%)
CH_ACTN_rpt2 139..252 CDD:409065 65/118 (55%)
SPEC 302..525 CDD:238103 91/222 (41%)
SPEC 420..647 CDD:238103 75/345 (22%)
SPEC 538..760 CDD:238103 61/409 (15%)
EFh 775..842 CDD:238008 16/119 (13%)
EFhand_Ca_insen 847..913 CDD:400872 13/65 (20%)
SPTBN2XP_006718732.1 CH 68..166 CDD:214479 50/97 (52%)
CH 184..287 CDD:237981 58/103 (56%)
Spectrin 312..421 CDD:278843 51/108 (47%)
Spectrin 436..529 CDD:278843 32/93 (34%)
SPEC 541..753 CDD:238103 33/224 (15%)
SPEC 756..965 CDD:238103 37/219 (17%)
SPEC 968..1179 CDD:238103 29/172 (17%)
SPEC 1181..1390 CDD:238103
SPEC 1391..1595 CDD:238103
SPEC 1596..1808 CDD:238103
SPEC 1809..2017 CDD:238103
SPEC 2025..>2082 CDD:197544
PH_beta_spectrin 2228..2331 CDD:269975
PH 2228..2331 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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