DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Actn and SPTBN1

DIOPT Version :9

Sequence 1:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster
Sequence 2:NP_003119.2 Gene:SPTBN1 / 6711 HGNCID:11275 Length:2364 Species:Homo sapiens


Alignment Length:1106 Identity:317/1106 - (28%)
Similarity:504/1106 - (45%) Gaps:288/1106 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 MENGLSMEYGDGYMEQE----------EEWEREGLLDPAWEKQ------------QKKTFTAWCN 45
            |...::.:|.:..::|:          ::|:.|......:|:.            ||||||.|.|
Human     1 MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVN 65

  Fly    46 SHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHL 110
            |||.:....|.::..|.|:|..|:.||||:|||.||||.:|:||.|.:.||:|||.|:..:.|||
Human    66 SHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHL 130

  Fly   111 VSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EEMTAKEGLLLWCQRKTAPYKNVNV 169
            .::|:.:|||||.::|||:||||||||.||||||      |:.:||:.||||||.|||.|.|||:
Human   131 ENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNI 195

  Fly   170 QNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTP 234
            .||..|::||:||.||||:|||||||:.||.|.|...||..||::||::|.:.::|||:| |:..
Human   196 HNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPED-ISVD 259

  Fly   235 KPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENER 299
            .|||::|:|||..|||.|...:.:.                      ....||.|||....|.|:
Human   260 HPDEKSIITYVVTYYHYFSKMKALA----------------------VEGKRIGKVLDNAIETEK 302

  Fly   300 LMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFN 364
            ::|:||.|||||||||.:|:..||:|:..|||.|||::|:.:.|||...|||:..:|..||....
Human   303 MIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367

  Fly   365 TLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKAD 429
            |:|:|:|.:|:..|:|.|||.:|||:.:|:.||.||...|..|..|.:|.|:||.||::|..||.
Human   368 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAA 432

  Fly   430 AHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDC 494
            ..|.|. .:.:.|.|||.....|..::|..|||||.|:|:||:::||:.:.|:|:||....|||.
Human   433 MRETWL-SENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDI 496

  Fly   495 VSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKI--DILHLEFAKRAAPFNNWLDGTR--- 554
            ..:.||...:...|:.|..|.:.||..| |....|:||  ::|::         .:|:|..:   
Human   497 KRITARKDNVIRLWEYLLELLRARRQRL-EMNLGLQKIFQEMLYI---------MDWMDEMKVLV 551

  Fly   555 ------------EDLVDMFIVHTMEEIQGLIQ--------------------------------- 574
                        |||:..   ||:.|....||                                 
Human   552 LSQDYGKHLLGVEDLLQK---HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRV 613

  Fly   575 AHDQF------------KATLGEADKEFNLIVNL------VREVESIVKQHQIPGGLENPYTTLT 621
            ||.:|            :|.|.|:.:.:.....:      :||.|.|:........|.:....|:
Human   614 AHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 678

  Fly   622 -----ANDMTRKWSDVRQLVPQRDQTLANE--------------------------LRKQQNNE- 654
                 .::|:.:.....|.:.:.:..:|.|                          :||::..| 
Human   679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 743

  Fly   655 MLRRQFAEKANIVGPWIERQMDAVTAIGMGL-QGSLEDQLHRLKEYEQAVYAYKPNIE------- 711
            .|..||...|:.:..|:...:..|::..:|. :.|.:..:.:.|:..:.:..|:|.::       
Human   744 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQAS 808

  Fly   712 ---------------------------ELEKIH-QAVQESMIFENRYTN---------------- 732
                                       ||.::. ||:|:::.....::.                
Human   809 ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLN 873

  Fly   733 --------YTMETLRVGWEQLLTSINRN------INEVENQIL------TRDSKGISQEQLNEFR 777
                    ..:|.::..:|.|...:|..      :|::..|::      .::.|. .|::||...
Human   874 NMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA-QQDKLNTRW 937

  Fly   778 SSFN-------------------HFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAV 823
            |.|.                   |.:.|.|.....|:.|  ::.....:|.|..|.:..||.|..
Human   938 SQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTK--VIESTQDLGNDLAGVMALQRKLTG 1000

  Fly   824 VDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQR 888
            ::.:   .|..:|.|..:.:|:                         ::|..| .||||:..:.|
Human  1001 MERD---LVAIEAKLSDLQKEA-------------------------EKLESE-HPDQAQAILSR 1036

  Fly   889 M 889
            :
Human  1037 L 1037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 54/115 (47%)
CH_ACTN_rpt2 139..252 CDD:409065 66/118 (56%)
SPEC 302..525 CDD:238103 96/222 (43%)
SPEC 420..647 CDD:238103 70/325 (22%)
SPEC 538..760 CDD:238103 50/385 (13%)
EFh 775..842 CDD:238008 16/85 (19%)
EFhand_Ca_insen 847..913 CDD:400872 7/43 (16%)
SPTBN1NP_003119.2 Actin-binding 2..275 126/273 (46%)
CH_SPTBN1_rpt1 3..156 CDD:409165 59/152 (39%)
SAC6 48..>530 CDD:227401 228/506 (45%)
CH_SPTB_like_rpt2 173..277 CDD:409097 59/104 (57%)
Spectrin 1. /evidence=ECO:0000255 303..411 51/107 (48%)
Spectrin 2. /evidence=ECO:0000255 423..525 39/103 (38%)
SPEC 530..743 CDD:238103 32/224 (14%)
Spectrin 3. /evidence=ECO:0000255 530..636 19/117 (16%)
Spectrin 4. /evidence=ECO:0000255 639..742 12/102 (12%)
SPEC 642..849 CDD:238103 29/206 (14%)
Spectrin 5. /evidence=ECO:0000255 745..847 15/101 (15%)
Spectrin 6. /evidence=ECO:0000255 850..952 12/102 (12%)
SPEC 851..1061 CDD:238103 34/219 (16%)
Spectrin 7. /evidence=ECO:0000255 957..1060 22/112 (20%)
SPEC 958..1169 CDD:238103 22/111 (20%)
Spectrin 8. /evidence=ECO:0000255 1063..1166
Spectrin 9. /evidence=ECO:0000255 1170..1258
SPEC 1171..1380 CDD:238103
Spectrin 10. /evidence=ECO:0000255 1276..1376
SPEC 1381..1592 CDD:238103
Spectrin 11. /evidence=ECO:0000255 1381..1482
Spectrin 12. /evidence=ECO:0000255 1486..1590
Interaction with ANK2. /evidence=ECO:0000269|PubMed:15262991 1563..2093
SPEC 1593..1805 CDD:238103
SPEC 1806..2027 CDD:238103
Spectrin 2017..>2075 CDD:395348
Spectrin 17. /evidence=ECO:0000255 2018..2097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2196
Mediates interaction with CAMSAP1. /evidence=ECO:0000269|PubMed:24117850 2149..2177
PH_beta_spectrin 2200..2305 CDD:269975
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2309..2364
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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