DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and SPTB

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001020029.1	Gene:	SPTB / 6710	HGNCID:	11274	Length:	2328	Species:	Homo sapiens

Alignment Length:	875	Identity:	298/875 - (34%)
Similarity:	438/875 - (50%)	Gaps:	136/875 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WEREGLLDPAWEKQ--QKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPD 84
            :||..:...|.|::  ||||||.|.||||.:....|.::.:|.|:|..|:.||||:|||.||||.
Human    40 FERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPT 104

  Fly    85 RGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----- 144
            :||||.|.:.||:|||.|:..:.|||.::|:.:|||||.::.||:||||||||.||||.|
Human   105 KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169

  Fly   145 -EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENL 208
             |..:||:.||||||.|||.|.:|||.||..|:||||||.||||:|||||||:.||...|...||
Human   170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNL 234

  Fly   209 NTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTY 273
            ..||:|||:.|.|..:|||:|:. |..|||::|:|||..:||.|...:.:.
Human   235 EHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLA-------------- 284

  Fly   274 VPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKL 338
                    ....|:.||:....|.|:::|:|..||||||.||.:|:..||||:..|||.|||::|
Human   285 --------VEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQL 341

  Fly   339 EEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAF 403
            :.:.|||...|||:.::|..||....|:|:::|.:|:..|.|.:||.||||:.:|:.||.||...
Human   342 QAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRR 406

  Fly   404 EEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESD 468
            |..|..|.:|.|:||.||::|..||...|.|. .:.:.|.:||.....|..::|.||||||.|:|
Human   407 ELALRNELIRQEKLEQLARRFDRKAAMRETWL-SENQRLVAQDNFGYDLAAVEAAKKKHEAIETD 470

  Fly   469 LAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKI- 532
            .||:::||..:..:||||....|||...:.||...|...|..|..|.|.||..| |....|:|:
Human   471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRL-ETTLALQKLF 534

  Fly   533 -DILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLG-EADKEFNLIVN 595
             |:||         ..:|:|..:..|:.......:.|::.|:|.|...:|.:. :.||...:...
Human   535 QDMLH---------SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAA 590

  Fly   596 LVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQF 660
            .::..|.  |.:|       |.......|   :.|.:.|...:.....|....:.:.::.|.:.|
Human   591 TLKFTEG--KGYQ-------PCDPQVIQD---RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFF 643

  Fly   661 AEKANIVGPWIERQMDAVTAIGMG--------LQ---GSLEDQLHRLKEYEQAVYAYKPNIEELE 714
            .| .:....||:.:....:::..|        ||   .:.||:|..|..:             ||
Human   644 WE-MDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH-------------LE 694

  Fly   715 KIHQAVQESMIFENRYTNYTMET----LRVGWEQ---LLTSINRNINEVEN-------------- 758
            :|.|.. ..|:...::.:..:|.    :...|:|   |.....:|:.:.||
Human   695 QIFQEA-HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAW 758

  Fly   759 -----QILTRDSKGISQ--------------EQLNEFRSSFNHFDKNRTGRLSPEEFK------- 797
                 ::|:.:..|..:              |:|.|.|....|.::...|  .||||:
Human   759 LQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG--FPEEFRDSPDVTH 821

  Fly   798 --SCLVSLGYSIGKDRQGDLDFQRILAVVD 825
              ..|..|...:  ..|.||..||:...:|
Human   822 RLQALRELYQQV--VAQADLRQQRLQEALD 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	55/105 (52%)
		CH_ACTN_rpt2	139..252	CDD:409065	67/118 (57%)
		SPEC	302..525	CDD:238103	96/222 (43%)
		SPEC	420..647	CDD:238103	65/229 (28%)
		SPEC	538..760	CDD:238103	42/259 (16%)
		EFh	775..842	CDD:238008	16/60 (27%)
		EFhand_Ca_insen	847..913	CDD:400872
SPTB	NP_001020029.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Actin-binding	2..275		126/235 (54%)
		SAC6	48..>438	CDD:227401	193/412 (47%)
		Spectrin 1. /evidence=ECO:0000255	303..411		49/107 (46%)
		Spectrin	422..525	CDD:306853	41/104 (39%)
		Spectrin 2. /evidence=ECO:0000255	423..525		41/103 (40%)
		Spectrin 3. /evidence=ECO:0000255	529..635		23/126 (18%)
		SPEC	530..742	CDD:238103	45/247 (18%)
		Spectrin 4. /evidence=ECO:0000255	638..741		22/117 (19%)
		SPEC	641..848	CDD:238103	42/225 (19%)
		Spectrin 5. /evidence=ECO:0000255	744..846		20/105 (19%)
		SPEC	745..954	CDD:238103	20/109 (18%)
		Spectrin 6. /evidence=ECO:0000255	851..950
		SPEC	955..1168	CDD:238103
		Spectrin 7. /evidence=ECO:0000255	956..1058
		Spectrin 8. /evidence=ECO:0000255	1062..1165
		SPEC	1170..1379	CDD:238103
		Spectrin 9. /evidence=ECO:0000255	1170..1257
		Spectrin 10. /evidence=ECO:0000255	1275..1375
		SPEC	1385..1475	CDD:197544
		Spectrin 11. /evidence=ECO:0000255	1389..1465
		Spectrin 12. /evidence=ECO:0000255	1481..1582
		SPEC	1485..1690	CDD:238103
		Spectrin 13. /evidence=ECO:0000255	1585..1688
		Spectrin 14. /evidence=ECO:0000255	1690..1793
		SPEC	1691..1901	CDD:238103
		Spectrin 15. /evidence=ECO:0000255	1797..1899
		SPEC	1798..2005	CDD:238103
		Spectrin 16. /evidence=ECO:0000255	1906..2006
		Spectrin 17. /evidence=ECO:0000255	2013..2075
		Spectrin	2013..>2070	CDD:306853
		PH_beta_spectrin	2181..2286	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920