DRSC/TRiP Functional Genomics Resources

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Protein Alignment Actn and SPTAN1

DIOPT Version :9

Sequence 1:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster
Sequence 2:NP_001362247.1 Gene:SPTAN1 / 6709 HGNCID:11273 Length:2510 Species:Homo sapiens


Alignment Length:1015 Identity:261/1015 - (25%)
Similarity:452/1015 - (44%) Gaps:202/1015 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 EKQQKKTFT-------AWCNSHLRKAGTAIDNIEEDFRNGLKLMLLL------EVISGETLPKPD 84
            |.|..:.|:       ||.:..|:   ||.|...:|..| ::|..||      :....|.....|
Human  1561 ESQTLQQFSRDVDEIEAWISEKLQ---TASDESYKDPTN-IQLSKLLSKHQKHQAFEAELHANAD 1621

  Fly    85 RGKMRFHKIANVNKALDFIASKGVHLVSIGA----EEIVDGNLKMTLGMIWTIILRFAIQDISVE 145
            |          :...:|.    |..|:..||    |:.|...| ..|...|    :|.:|..:.:
Human  1622 R----------IRGVIDM----GNSLIERGACAGSEDAVKARL-AALADQW----QFLVQKSAEK 1667

  Fly   146 EMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCA-------------LIHRHRPDLIDYA 197
            ....||.      .|...: |..:::|.....:..|..|             |:.:|:  |::..
Human  1668 SQKLKEA------NKQQNF-NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQ--LLEAD 1723

  Fly   198 KLSKDNPLENLNTAFD--VAEKYLDIPRMLDPDDLIN-------TPKPDERAIMTYVSCYYHAFQ 253
            ..:.::.|::||:..|  :.....|..::.|..|.||       :.....||.:......:..|:
Human  1724 ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1788

  Fly   254 ----------------GAQQVGNVTHVPEPTRQYTYVPN------NYNAETAANR--ICKVL--- 291
                            |::..|         |..|.|.|      ...||.||:.  |..||   
Human  1789 DMDDEESWIKEKKLLVGSEDYG---------RDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1844

  Fly   292 -KVNQEN-----------------------------ERLME--EYERLASDLLE---WIRRTMPW 321
             |::.:|                             :||.|  ||::..:::.|   ||...|..
Human  1845 KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTL 1909

  Fly   322 LNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLR--LSNRPAYLPTEGK 384
            :.|....::||.:|..|:::..:               ||:|...:.::.  .:|....:.....
Human  1910 VASEDYGDTLAAIQGLLKKHEAF---------------ETDFTVHKDRVNDVCTNGQDLIKKNNH 1959

  Fly   385 TVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQ--KFKHKADAHEDWTRGKEEMLQSQDF 447
            ...:||:..|||.......|:   |...|..:|:..:.  :|..|||..|.|...||..|::.|:
Human  1960 HEENISSKMKGLNGKVSDLEK---AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDY 2021

  Fly   448 RQCKLNELKALKKKHEAFESDLAA-HQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRL 511
            .: .|:.::.|..|.|.|::.|.| .|:.:..|.|:..:|...::....::.||...:..:|.:|
Human  2022 GR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQL 2085

  Fly   512 GALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAH 576
            .|.:..|:..|.||:....|::.|.|.|||:|:.||:|.:...|||.|....:::|||:.|.:||
Human  2086 LANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAH 2150

  Fly   577 DQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQ 641
            |.|:::|..|..:||.:..|.|:::|.       ....||||..|...:...|.::::::.:|:.
Human  2151 DAFRSSLSSAQADFNQLAELDRQIKSF-------RVASNPYTWFTMEALEETWRNLQKIIKEREL 2208

  Fly   642 TLANELRKQQNNEMLRRQFAEKANIVGPWIERQ----MDAVT----------AIGMGL------- 685
            .|..|.|:|:.|:.||::||:.||....||:..    :|.:.          .:|..|       
Human  2209 ELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGIAYRRVIRVYQYEVGDDLSGRSCMV 2273

  Fly   686 --QGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTS 748
              .|:||.||...|...|.:.|.:..::::|.:..|::|::|.:|:||.::...|...|:||...
Human  2274 EESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQL 2338

  Fly   749 INRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQG 813
            ..|..:.:|.||..|::.|:::|.|.||...|.||||:::|||:.:||||||.||||.:....:|
Human  2339 GMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEG 2403

  Fly   814 --DLDFQRILAVVDPNNTGYVHFDAFLDFM-TRESTDTDTAEQVIDSFRILAAD-KPYILPDELR 874
              |.:|:.||..||||..|:|....::.|| :||:.:..::|::..:||.|::: |||:..:||.
Human  2404 EPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELY 2468

  Fly   875 RELPPDQAEYCIQRMPPYKGPNG--VPGALDYMSFSTALY 912
            :.|..:||:||:..|.||....|  :|.|.||:.|:.:|:
Human  2469 QNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLF 2508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 27/118 (23%)
CH_ACTN_rpt2 139..252 CDD:409065 22/134 (16%)
SPEC 302..525 CDD:238103 53/232 (23%)
SPEC 420..647 CDD:238103 67/229 (29%)
SPEC 538..760 CDD:238103 70/244 (29%)
EFh 775..842 CDD:238008 33/69 (48%)
EFhand_Ca_insen 847..913 CDD:400872 24/69 (35%)
SPTAN1NP_001362247.1 Spectrin 56..158 CDD:334073
SPEC 162..373 CDD:238103
SPEC 374..584 CDD:238103
SPEC 480..690 CDD:238103
SPEC 691..902 CDD:238103
Spectrin 902..>983 CDD:334073
SH3_Alpha_Spectrin 983..1035 CDD:212742
SPEC 1104..1351 CDD:238103
SPEC 1246..1457 CDD:238103
SPEC 1458..1675 CDD:238103 31/142 (22%)
Spectrin 1675..1777 CDD:334073 19/104 (18%)
SPEC 1782..1991 CDD:238103 43/235 (18%)
SPEC 1888..2099 CDD:238103 52/229 (23%)
SPEC 1995..2213 CDD:238103 67/225 (30%)
SPEC 2113..2350 CDD:238103 70/243 (29%)
EFh 2365..2433 CDD:238008 31/67 (46%)
EFhand_Ca_insen 2440..2508 CDD:312305 23/67 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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