DRSC/TRiP Functional Genomics Resources

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Protein Alignment Actn and SPTA1

DIOPT Version :9

Sequence 1:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster
Sequence 2:NP_003117.2 Gene:SPTA1 / 6708 HGNCID:11272 Length:2419 Species:Homo sapiens


Alignment Length:1016 Identity:233/1016 - (22%)
Similarity:431/1016 - (42%) Gaps:208/1016 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLL 71
            |...|.|  :|:.|||..|.|                        .||.|...:|..|..:..|.
Human  1502 LKQFYRD--LEELEEWISEML------------------------PTACDESYKDATNIQRKYLK 1540

  Fly    72 LEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGN---LKMTLGMI--- 130
            .:..:.|.    |....:.|.:.|:          |..|:...|   .|||   :|..|..:   
Human  1541 HQTFAHEV----DGRSEQVHGVINL----------GNSLIECSA---CDGNEEAMKEQLEQLKEH 1588

  Fly   131 WTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFH---------LSFKDGLAFCA-- 184
            |..:|          |.|..:|..|....:...: |.::::|.         |:.||.....|  
Human  1589 WDHLL----------ERTNDKGKKLNEASRQQRF-NTSIRDFEFWLSEAETLLAMKDQARDLASA 1642

  Fly   185 --LIHRHRPDLIDYAKLSKDNPLENLNTAFD-------------------VAEKYLDIPRML--- 225
              |:.:|:  |::...|::::.|::|||..:                   |.:::|::..:.   
Human  1643 GNLLKKHQ--LLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAH 1705

  Fly   226 ---------------DPDDLINTPKPDERAIMTYVSCYYHAFQGAQQV--------GN-VTHVPE 266
                           |.||  .....:|:.|......|....||.|.:        |. |.|  |
Human  1706 HEKLKEAYALFQFFQDLDD--EESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAH--E 1766

  Fly   267 PTRQYTYVPNNYNAETAANRICKVLKVNQENERL-----MEEYERL----------ASDLLEWIR 316
            |..|        |....|.::.....|.||..:|     :|.:|:|          ..:.||:::
Human  1767 PAIQ--------NVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ 1823

  Fly   317 ------RTMPWLNSRQA-------DNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQT 368
                  ....|:|.:.|       .::||..|..|       .||:        .||.:|...:|
Human  1824 FMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLL-------MKHE--------ALENDFAVHET 1873

  Fly   369 KLR--------LSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFK 425
            :::        :.|:.....::.|   :||:..:.|.....:..:.:.|..::||. ::..|:|.
Human  1874 RVQNVCAQGEDILNKVLQEESQNK---EISSKIEALNEKTPSLAKAIAAWKLQLED-DYAFQEFN 1934

  Fly   426 HKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAA-HQDRVEQIAAIAQELNTL 489
            .|||..|.|...||..|::.. ....|.:...|..|.:..::.|.: .|:|:.:|..:..:|.:.
Human  1935 WKADVVEAWIADKETSLKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISA 1998

  Fly   490 EYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTR 554
            :::...::..|...:..:|::|...:...|..|.|.:..|:|.:.|.:|||.:|:..|||.:...
Human  1999 QHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKME 2063

  Fly   555 EDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTT 619
            |:|.:.....::.||:.|.:.|:.|.|:|..|..:|..::.|.::::::       |...:|||.
Human  2064 ENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKAL-------GVPSSPYTW 2121

  Fly   620 LTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMG 684
            ||...:.|.|..:..::.:|:|.|..|..:|..|..:.::|.:.|:....|| .:..|....|..
Human  2122 LTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI-LETRAYFLDGSL 2185

  Fly   685 LQ--GSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLT 747
            |:  |:||.||...|..::.:.|.|..:.::..:...:::::|.:.:|:..   .|...|:||..
Human  2186 LKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQQWDQLYQ 2247

  Fly   748 SINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIG--KD 810
            ...|..:.:|.||..:|.||:|:|.|.||.:.:.|||:|.||||:.:||:|||..|.|.:.  ::
Human  2248 LGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEE 2312

  Fly   811 RQGDLDFQRILAVVDPNNTGYVHFDAFLDFM-TRESTDTDTAEQVIDSFRILAADKPYILPDELR 874
            .:.:..|::.|..|||...|||..:.:..|: .:||.:..:::::.::|:.||..|.||..::::
Human  2313 DEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMK 2377

  Fly   875 RELPPDQAEYCIQRMPPYKGPNGVP--GALDYMSFSTALYG 913
            :.|.|:|..:|...|..|..|.|..  ...||:.|:.:.:|
Human  2378 QALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFG 2418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 19/109 (17%)
CH_ACTN_rpt2 139..252 CDD:409065 26/162 (16%)
SPEC 302..525 CDD:238103 49/254 (19%)
SPEC 420..647 CDD:238103 57/227 (25%)
SPEC 538..760 CDD:238103 56/223 (25%)
EFh 775..842 CDD:238008 26/69 (38%)
EFhand_Ca_insen 847..913 CDD:400872 17/67 (25%)
SPTA1NP_003117.2 Spectrin 1. /evidence=ECO:0000255 53..155
Spectrin 53..138 CDD:278843
SPEC 159..370 CDD:238103
Spectrin 2. /evidence=ECO:0000255 159..261
Spectrin 3. /evidence=ECO:0000255 265..367
SPEC 266..476 CDD:238103
Spectrin 4. /evidence=ECO:0000255 371..474
SPEC 477..687 CDD:238103
Spectrin 5. /evidence=ECO:0000255 477..580
Spectrin 6. /evidence=ECO:0000255 583..685
SPEC 688..897 CDD:238103
Spectrin 7. /evidence=ECO:0000255 688..790
Spectrin 8. /evidence=ECO:0000255 794..896
Spectrin 9. /evidence=ECO:0000255 900..969
SPEC 902..>958 CDD:197544
SH3 982..1033 CDD:302595
Spectrin 1082..1179 CDD:278843
Spectrin 10. /evidence=ECO:0000255 1087..1179
Spectrin 11. /evidence=ECO:0000255 1185..1287
SPEC 1186..1395 CDD:238103
Spectrin 12. /evidence=ECO:0000255 1290..1392
SPEC 1396..1606 CDD:238103 33/156 (21%)
Spectrin 13. /evidence=ECO:0000255 1396..1497
Spectrin 14. /evidence=ECO:0000255 1501..1605 33/155 (21%)
SPEC 1608..1819 CDD:238103 40/225 (18%)
Spectrin 15. /evidence=ECO:0000255 1608..1711 16/105 (15%)
Spectrin 16. /evidence=ECO:0000255 1714..1817 24/114 (21%)
SPEC 1715..1926 CDD:238103 46/240 (19%)
Spectrin 17. /evidence=ECO:0000255 1820..1926 21/123 (17%)
Spectrin 18. /evidence=ECO:0000255 1929..2033 23/104 (22%)
SPEC 1930..2148 CDD:238103 57/225 (25%)
Spectrin 19. /evidence=ECO:0000255 2044..2146 30/108 (28%)
SPEC 2047..2260 CDD:238103 56/223 (25%)
Spectrin 20. /evidence=ECO:0000255 2158..2258 22/103 (21%)
EFh 2275..2343 CDD:298682 25/67 (37%)
EF-hand_7 2278..2343 CDD:290234 23/64 (36%)
EFhand_Ca_insen 2350..2418 CDD:285885 17/67 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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