Protein Alignment Actn and Actn4

DIOPT Version :10

• Sequence 1: NP_477485.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_006540320.1
• Gene: Actn4 / 60595
• MGIID: 1890773
• Length: 934
• Species: Mus musculus
• Alignment Length: 934
• Identity: 617/934 - (66%)
• Similarity: 746/934 - (79%)
• Gaps: 47/934 - (5%)

  Fly     6 GLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLML 70
            |.||  || ||.||::|:|:.||||||||||:||||||||||||||||.|:||:||||:||||||
Mouse    26 GGSM--GD-YMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLML 87

  Fly    71 LLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIIL 135
            ||||||||.||||:|||||.|||.||||||||||||||.|||||||||||||.||||||||||||
Mouse    88 LLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIIL 152

  Fly   136 RFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLS 200
            |||||||||||.:|||||||||||||||||||||||||:|:||||||.||||||||:||:|.||.
Mouse   153 RFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLR 217

  Fly   201 KDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVP 265
            ||:|:.|||.||:|||||||||:|||.:|::||.:|||:|||||||.:||||.|||:
Mouse   218 KDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQK-------- 274

  Fly   266 EPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNS 330
                          ||||||||||||.||||||.|||:|||||||||||||||:|||..|....:
Mouse   275 --------------AETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKT 325

  Fly   331 LAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKG 395
            :..:|:|||::|.|||.||||:|::|.:||.||||||||||||||||::|:||:.||||:|.|:.
Mouse   326 IQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQH 390

  Fly   396 LELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKK 460
            ||.|||.:|||||.|..|||||:|||:||:.||..||.||.|||.||:.:|:....|:::|||.:
Mouse   391 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKQRDYETATLSDIKALIR 455

  Fly   461 KHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEA 525
            |||||||||||||||||||||||||||.|:|:|..:||.|||:||||||.||:||..||.||::.
Mouse   456 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKT 520

  Fly   526 ERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEF 590
            |:.||.||.||||:||||||||||::...|||.|||||||:|||:|||.||||||:||.:||:|.
Mouse   521 EKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRER 585

  Fly   591 NLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEM 655
            ..|:.:.:|.:.|.:.:.|.....|||||:|...:..||..|:||||:||..|..|..|||:||.
Mouse   586 EAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 650

  Fly   656 LRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAV 720
            ||||||.:||:|||||:.:|:.:..|.:.:.|:|||||..||:||:::..|||:::.||:.||.:
Mouse   651 LRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPSLDLLEQQHQLI 715

  Fly   721 QESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDK 785
            ||::||:|::||||||.:|||||||||:|.|.||||||||||||:|||||||:.|||:|||||||
Mouse   716 QEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDK 780

  Fly   786 NRTGRLSPEEFKSCLVSLGYSIGKDRQ----------------------GDLDFQRILAVVDPNN 828
            :..|.|.|||||:||:||||.:..|||                      ||.:|.||::|||||:
Mouse   781 DHGGALGPEEFKACLISLGYDVENDRQKQTGSMDSDDFRALLISTGYSLGDAEFNRIMSVVDPNH 845

  Fly   829 TGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYK 893
            :|.|.|.||:|||:||:||||||:|||.||::||.||.:|..:|||||||||||||||.||.||:
Mouse   846 SGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQ 910

  Fly   894 GPNGVPGALDYMSFSTALYGETDL 917
            ||:..||||||.|||||||||:||
Mouse   911 GPDAAPGALDYKSFSTALYGESDL 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_477485.1	CH_ACTN_rpt1	31..135	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	139..252	CDD:409065	88/112 (79%)
		SPEC	302..525	CDD:238103	147/222 (66%)
		SPEC	420..647	CDD:238103	135/226 (60%)
		SPEC	538..760	CDD:238103	124/221 (56%)
		EFh	775..842	CDD:238008	43/88 (49%)
		EFhand_Ca_insen	847..913	CDD:430177	48/65 (74%)
Actn4	XP_006540320.1	CH_ACTN_rpt1	48..152	CDD:409063	92/103 (89%)
		CH_ACTN_rpt2	156..270	CDD:409065	89/113 (79%)
		SPEC	297..518	CDD:238103	146/220 (66%)
		SPEC	415..641	CDD:238103	135/225 (60%)
		SPEC	533..755	CDD:238103	124/221 (56%)
		PTZ00184	760..>891	CDD:185504	70/130 (54%)
		EFhand_Ca_insen	864..930	CDD:430177	48/65 (74%)