DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and SPTBN4

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_066022.2	Gene:	SPTBN4 / 57731	HGNCID:	14896	Length:	2564	Species:	Homo sapiens

Alignment Length:	784	Identity:	270/784 - (34%)
Similarity:	395/784 - (50%)	Gaps:	125/784 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WERE------------------GLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKL 68
            ||||                  .|.|.. |..||||||.|.||||.:.|..|.::..|.|:|..|
Human    32 WEREQPAASTAAASLFECSRIKALADER-EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVL 95

  Fly    69 MLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTI 133
            ..||||:|||.||:|.||:||.|.:.||:|||.|:..:.|||.::|:.:|||||.::|||::|||
Human    96 TRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTI 160

  Fly   134 ILRFAIQDISV------EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPD 192
            ||||.||.|.:      |..:||:.||||||.|||.|..||:|||..|::|||||.|||||||||
Human   161 ILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPD 225

  Fly   193 LIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQ 257
            |:|::||:|.|...||..||..||::|.:.|:|||:| :|...|||::|:|||..:||.|...:.
Human   226 LVDFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKA 289

  Fly   258 VGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWL 322
            :.                      ....||.|||....|..:::|.||.||::||.||.||:..:
Human   290 LA----------------------VEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLI 332

  Fly   323 NSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVS 387
            ::::..|||:|||::|:.:..|....||.:.::|..||....::|:|||..||..::|.||..:.
Human   333 SNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIW 397

  Fly   388 DISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKL 452
            ||..:|..||.||...|..|.||.:|.|:||.|||:|.||....|.|. .:.:.|.|||....:|
Human   398 DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWL-NENQRLVSQDNFGYEL 461

  Fly   453 NELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQR 517
            ..::|..|||||.|:|:||:::||:.:|.:||.|....|:|...|.|:...:..||..|..|...
Human   462 PAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGA 526

  Fly   518 RRTALD------------------------------------EAERILEKIDILHLEFA---KRA 543
            |||.|:                                    ||:.:|:|..:|..:.|   :|.
Human   527 RRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERV 591

  Fly   544 APFN------NWLDGTREDLVDMFIVHTMEEIQG-LIQAHDQF---KATLGEADKEFNLIVNLVR 598
            ...|      :.|.| .:......|.:.:..:.| |.:..:|.   :|.| ||.:....::..:.
Human   592 EALNAAALRFSQLQG-YQPCDPQVICNRVNHVHGCLAELQEQAARRRAEL-EASRSLWALLQELE 654

  Fly   599 EVESIVKQHQ----------IPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANEL--RKQQ 651
            |.||..:..:          ..|......|...|:|:    |...:|:.|. :.|..||  |:..
Human   655 EAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDL----SSTARLLAQH-KILQGELGGRRAL 714

  Fly   652 NNEMLR--RQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELE 714
            ..:.||  .:.......|||    ..|.|..:|:..:.:  ....|.:..|:|....:..::|..
Human   715 LQQALRCGEELVAAGGAVGP----GADTVHLVGLAERAA--SARRRWQRLEEAAARRERRLQEAR 773

  Fly   715 KIHQ 718
            .:||
Human   774 ALHQ 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	54/103 (52%)
		CH_ACTN_rpt2	139..252	CDD:409065	64/118 (54%)
		SPEC	302..525	CDD:238103	89/258 (34%)
		SPEC	420..647	CDD:238103	70/285 (25%)
		SPEC	538..760	CDD:238103	41/208 (20%)
		EFh	775..842	CDD:238008
		EFhand_Ca_insen	847..913	CDD:400872
SPTBN4	NP_066022.2	Actin-binding	1..282		126/251 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		4/4 (100%)
		CH	62..165	CDD:237981	56/102 (55%)
		CH	181..284	CDD:237981	60/103 (58%)
		SPEC	311..419	CDD:295325	42/107 (39%)
		Spectrin 1. /evidence=ECO:0000255	311..418		41/106 (39%)
		SPEC	430..644	CDD:238103	59/216 (27%)
		Spectrin 2. /evidence=ECO:0000255	430..533		41/103 (40%)
		Spectrin 3. /evidence=ECO:0000255	536..641		16/106 (15%)
		Spectrin 4. /evidence=ECO:0000255	774..879		2/4 (50%)
		SPEC	775..987	CDD:238103	2/3 (67%)
		Spectrin 5. /evidence=ECO:0000255	884..982
		Spectrin 6. /evidence=ECO:0000255	1089..1196
		SPEC	1091..1195	CDD:197544
		SPEC	1201..1409	CDD:238103
		SPEC	1306..1514	CDD:238103
		Spectrin 7. /evidence=ECO:0000255	1306..1407
		Spectrin 8. /evidence=ECO:0000255	1412..1512
		Spectrin 9. /evidence=ECO:0000255	1515..1617
		SPEC	1516..1727	CDD:238103
		SPEC	1622..1834	CDD:238103
		Spectrin 10. /evidence=ECO:0000255	1623..1725
		Spectrin 11. /evidence=ECO:0000255	1728..1830
		Spectrin	1834..1933	CDD:278843
		Spectrin 12. /evidence=ECO:0000255	1835..1935
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1853..1872
		SPEC	1943..>2110	CDD:238103
		Spectrin 13. /evidence=ECO:0000255	1944..2046
		Spectrin 14. /evidence=ECO:0000255	2049..2123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2208..2439
		PH	2419..2527	CDD:278594
		PH_beta_spectrin	2421..2525	CDD:269975
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2533..2564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920