DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and actn2

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001005053.1	Gene:	actn2 / 448602	XenbaseID:	XB-GENE-489122	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	596/903 - (66%)
Similarity:	734/903 - (81%)	Gaps:	27/903 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGET 79
            ||.|||||:|:.||||||||||:||||||||||||||||.|:||||||||||||||||||||||.
Frog    19 YMNQEEEWDRDMLLDPAWEKQQRKTFTAWCNSHLRKAGTMIENIEEDFRNGLKLMLLLEVISGER 83

  Fly    80 LPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV 144
            |||||||||||||||||||||||||||||.|||||||||||||:|||||||||||||||||||||
Frog    84 LPKPDRGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV 148

  Fly   145 EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLN 209
            ||.:||||||||||||||||:|||:||||.|:||||..||||||||||||||:||:||:.:.|:|
Frog   149 EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDAVGNIN 213

  Fly   210 TAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYV 274
            .|.||||||||||:|||.:|:::|.|||||||||||||:||||.||:|
Frog   214 LAMDVAEKYLDIPKMLDAEDIVSTAKPDERAIMTYVSCFYHAFAGAEQ----------------- 261

  Fly   275 PNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLE 339
                 ||||||||||||.|||||||:|||||||||:||||||||:|||.:|.::.::..:.||||
Frog   262 -----AETAANRICKVLAVNQENERMMEEYERLASELLEWIRRTIPWLENRTSEKTMQAMLKKLE 321

  Fly   340 EYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFE 404
            ::|.||||||||||::|.:||.||||||||||:|||||::|:|||.||||:|:|:.||..||.:|
Frog   322 DFRDYRRKHKPPRVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIANAWQRLEQGEKGYE 386

  Fly   405 EWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDL 469
            ||||.|..||||:||||:||:.||..||.||.|||::|..:|:....|.|::||.:|||||||:|
Frog   387 EWLLTELRRLERVEHLAEKFRQKASLHESWTAGKEQLLLQKDYETASLTEVRALLRKHEAFESEL 451

  Fly   470 AAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDI 534
            ||.|||||||||||||||.|:|:|...:|.|||:|||||||||.|||:||.||:..|::||.:|.
Frog   452 AARQDRVEQIAAIAQELNELDYYDAARINERCQKICDQWDRLGTLTQKRREALERTEKLLETVDQ 516

  Fly   535 LHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVRE 599
            |||||.|||.|||.|::|..|||.||||||.:||||.||.||:||||||.|||.|...|:.:..|
Frog   517 LHLEFIKRAGPFNIWMEGAMEDLQDMFIVHNVEEIQKLITAHEQFKATLPEADSERQAILGIQNE 581

  Fly   600 VESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKA 664
            ||.:::.:.|.....|||:::|.:::..||..|:||||.|||||..||.:|||||.||||||.:|
Frog   582 VEKVIQSYNIKISSHNPYSSITLDEIRTKWEKVKQLVPIRDQTLQEELARQQNNERLRRQFAGQA 646

  Fly   665 NIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENR 729
            |::||||::||:.:....:...|:||||::.||..|..:..||.|:::||..||.:|||:||:|:
Frog   647 NVIGPWIQKQMEEIGRSCIDFTGTLEDQMNSLKMLEHNIVNYKHNVDKLEGDHQMIQESLIFDNK 711

  Fly   730 YTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPE 794
            :|||:||.:|||||.:||::.|.|||||.||||||:|||:|||:|.||||||||||.:.|.:..:
Frog   712 HTNYSMEHIRVGWELMLTTVARTINEVETQILTRDAKGITQEQINVFRSSFNHFDKKKNGLMEHD 776

  Fly   795 EFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFR 859
            :|::||:|:||.:     |:.:|.||:|:|||:..|.:.|.:|:||||||:.:|||:||||.:||
Frog   777 DFRACLISMGYDL-----GEAEFARIMALVDPSGIGTISFQSFIDFMTRETAETDTSEQVIAAFR 836

  Fly   860 ILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL 917
            |||||||||||:||||||||:||:||:.:||.|.||..||||||:..||:|||||:||
Frog   837 ILAADKPYILPEELRRELPPEQAQYCLSKMPTYTGPGAVPGALDFTCFSSALYGESDL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	97/103 (94%)
		CH_ACTN_rpt2	139..252	CDD:409065	87/112 (78%)
		SPEC	302..525	CDD:238103	146/222 (66%)
		SPEC	420..647	CDD:238103	132/226 (58%)
		SPEC	538..760	CDD:238103	118/221 (53%)
		EFh	775..842	CDD:238008	30/66 (45%)
		EFhand_Ca_insen	847..913	CDD:400872	47/65 (72%)
actn2	NP_001005053.1	CH_ACTN_rpt1	35..139	CDD:409063	97/103 (94%)
		CH_ACTN_rpt2	143..257	CDD:409065	88/113 (78%)
		Spectrin	281..390	CDD:395348	72/108 (67%)
		SPEC	402..629	CDD:238103	132/226 (58%)
		Spectrin	637..739	CDD:395348	51/101 (50%)
		FRQ1	750..860	CDD:227455	68/114 (60%)
		EFhand_Ca_insen	824..890	CDD:400872	47/65 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1299	1.000	Inparanoid score	I158
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	1	1.000	-	-		FOG0000815
OrthoInspector	1	1.000	-	-		otm49049
Panther	1	1.100	-	-	O	PTHR11915
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160