DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actn and kst

DIOPT Version :9

Sequence 1:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001097492.2	Gene:	kst / 38418	FlyBaseID:	FBgn0004167	Length:	4337	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	271/895 - (30%)
Similarity:	428/895 - (47%)	Gaps:	183/895 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NGLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLM 69
            |..:|...||.::.|.  ||...|.......||||||.|.||.|.||...::::..|..:|:||:
  Fly    48 NSANMTQRDGIIKFEN--ERIKTLQEERLHIQKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLL 110

  Fly    70 LLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTII 134
            .|||:||.|.|.||:.|:||.|||.||||:|.|:.:| |.|.|||||:|||||.::.||:|||||
  Fly   111 KLLEIISSEKLGKPNSGRMRVHKIENVNKSLAFLHTK-VRLESIGAEDIVDGNPRLILGLIWTII 174

  Fly   135 LRFAIQDISV---------EEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHR 190
            |||.||:|.:         |:.:||:.|||||||||..|..||:.:|..|::.||.|.||||.||
  Fly   175 LRFQIQEIEIDVDEENESSEKRSAKDALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHR 239

  Fly   191 PDLIDYAKL--SKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQ 253
            |||.:|:.:  ||::.|:|||.|||.|...|.||.:||.:| |::.:|||::|:|||:.|||.|.
  Fly   240 PDLFEYSTIVNSKNSNLDNLNHAFDTAANELGIPSLLDAED-IDSARPDEKSILTYVASYYHTFA 303

  Fly   254 GAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRT 318
            ..:                      |.:.:..||..::....:.:|...:||.|.::||.|||:.
  Fly   304 RMK----------------------NEQKSGKRIANIVGQLMDADRKKMQYEGLTTNLLSWIRQK 346

  Fly   319 MPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEG 383
            ...|..|...|||.|:|::|..::.||...|||:.::::::|..:.|:.|.|:..|:|.|.|.:|
  Fly   347 TLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEIEALYFTINTLLKALNQPPYNPQDG 411

  Fly   384 KTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQ-SQDF 447
            :.|:||..:|:.||.||...|..|..|.:|.|:||.|..||:.|:...|.:.:   ||:| ..|.
  Fly   412 QLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQLNYKFEKKSVLREGYLK---EMIQVLSDP 473

  Fly   448 RQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLG 512
            |.  |.::.|..|||||..:|:.|..:|...:.|:|:||:...||....|..|.|.:..:|.:|.
  Fly   474 RY--LRQVDATLKKHEAISADILARVERFNDLTAMAEELDRENYHGKERVRRREQEVMAKWRQLL 536

  Fly   513 ALTQRRRTALDEAERIL----------EKIDILHLEFAKR-AAPFNNWLDGTREDLVDMFIVHTM 566
            .|.:.:|..|.:...::          |.:..|..:||.. ..|.   |.|..|    :...|::
  Fly   537 ELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFASEDVGPH---LLGVEE----LLQAHSL 594

  Fly   567 EEIQGLIQAHDQFKATLGEADKEFN---------------LIVNLVREVESIVKQ---------- 606
            :|:|         ..|.||..|.||               |:...:.::|....:
  Fly   595 QELQ---------VNTYGETLKRFNRQALPYKSSEHKDAALLAQRLADLEEAYSELLRRSAARRA 650

  Fly   607 --------HQIPGGLENP-----------YTTLTANDMTRKWSDVRQLVPQRDQTLANEL--RKQ 650
                    |......:|.           .|.:||.|:....|     :.|:.:.|.:|:  ||.
  Fly   651 RLEEARNFHHFMEDYDNEESWLVDKQRICKTGITAKDLRAVLS-----LQQKHKALEDEIKSRKP 710

  Fly   651 QNNEMLRRQFAEKANIVGPW------IERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAY--- 706
            ::.:|   ..|.| .::|..      |:.::|::......|:..:|.:..:|::..:|...|
  Fly   711 KSGQM---STAGK-RLIGEQHPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQFYTDA 771

  Fly   707 ----------------------KPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSI 749
                                  :|:.:.|.:.|:.:|..:   |.|:...:
  Fly   772 NEAESWLNEKIALVNSRDYGNDEPSAQALLQRHRDLQGEL---NAYSGDIL-------------- 819

  Fly   750 NRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDK----NRTGRLSPEE 795
              |:|:..::::   ..||...:|:.........::    |.| ||.|:|
  Fly   820 --NLNQQADKLI---KAGICTLELSAAEPELPEVEQEEWVNET-RLVPKE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	56/103 (54%)
		CH_ACTN_rpt2	139..252	CDD:409065	60/123 (49%)
		SPEC	302..525	CDD:238103	79/223 (35%)
		SPEC	420..647	CDD:238103	62/282 (22%)
		SPEC	538..760	CDD:238103	48/299 (16%)
		EFh	775..842	CDD:238008	6/25 (24%)
		EFhand_Ca_insen	847..913	CDD:400872
kst	NP_001097492.2	CH	76..178	CDD:237981	59/102 (58%)
		CH	197..303	CDD:237981	56/106 (53%)
		SPEC	450..640	CDD:238103	52/210 (25%)
		SPEC	658..832	CDD:238103	31/204 (15%)
		SH3	885..935	CDD:214620
		SPEC	1030..1236	CDD:238103
		SPEC	1134..1341	CDD:238103
		SPEC	1343..1551	CDD:238103
		SPEC	1449..1658	CDD:238103
		SPEC	1555..1764	CDD:238103
		SPEC	1765..1975	CDD:238103
		SPEC	1873..2080	CDD:238103
		SPEC	1979..2185	CDD:238103
		SPEC	2188..2402	CDD:238103
		SPEC	2407..2618	CDD:238103
		SPEC	2514..2725	CDD:238103
		SPEC	2726..2934	CDD:238103
		SPEC	2935..3145	CDD:238103
		SPEC	3042..3251	CDD:238103
		SPEC	3149..3357	CDD:238103
		SPEC	3359..3567	CDD:238103
		SPEC	3465..3680	CDD:238103
		PH	3799..3902	CDD:278594
		PH_beta_spectrin	3801..3904	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439910
Domainoid	1	1.000	106	1.000	Domainoid score	I1672
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47215
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R34
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.880